STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett’s adenocarcinomas
Timme S, Ihde S, Fichter C, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett’s adenocarcinomas. Oncogene 2013, 33: 3256-3266. PMID: 23912451, DOI: 10.1038/onc.2013.298.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBarrett EsophagusCarcinoma, Squamous CellCell CycleCell Growth ProcessesCell Line, TumorCell MovementDown-RegulationEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaGene Knockdown TechniquesHumansPhosphorylationSignal TransductionSTAT3 Transcription FactorUp-RegulationConceptsSTAT3 knockdownSTAT3 expressionCell migrationEpidermal growth factorSTAT3 activationSTAT3-regulated genesP-STAT3STAT3 Tyr705 phosphorylationOE33 cellsOE21 cellsCell cycle genesActive p-Stat3Migration of ESCC cellsBAC cellsCell proliferationSTAT3 Tyr705Cell motilityEsophageal squamous cell carcinomaTherapeutic targetCycle genesReduced cell proliferationCellular functionsSignal transducerSTAT3 inhibitionSTAT3
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