ARID1A expression in early stage colorectal adenocarcinoma: an exploration of its prognostic significance
Lee L, Sadot E, Ivelja S, Vakiani E, Hechtman J, Sevinsky C, Klimstra D, Ginty F, Shia J. ARID1A expression in early stage colorectal adenocarcinoma: an exploration of its prognostic significance. Human Pathology 2016, 53: 97-104. PMID: 26980037, PMCID: PMC4994515, DOI: 10.1016/j.humpath.2016.02.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCell DifferentiationColorectal NeoplasmsDisease ProgressionDisease-Free SurvivalDNA Mismatch RepairDNA Repair EnzymesDNA-Binding ProteinsFemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNuclear ProteinsProportional Hazards ModelsRetrospective StudiesTime FactorsTissue Array AnalysisTranscription FactorsTreatment OutcomeYoung AdultConceptsColorectal carcinomaPrognostic significanceARID1A lossARID1A expressionPrognostic value of ARID1AEarly stage CRC patientsRecurrence-free survivalMedian Follow-UpAssociated with female sexStage CRC patientsChromatin remodeling genesLoss of ARID1AHeterogeneous patient populationLymphovascular invasionCurative intentPT stageAdjuvant therapyRetrospective seriesMismatch repair protein deficiencyPrognostic valueTissue microarrayEarly stage CRCPrognostic markerCRC patientsAnalyzed tumors
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