2024
Bioengineering of vascularized porcine flaps using perfusion-recellularization
Xu M, D’Elia A, Hadzimustafic N, Adil A, Karoubi G, Waddell T, Haykal S. Bioengineering of vascularized porcine flaps using perfusion-recellularization. Scientific Reports 2024, 14: 7590. PMID: 38555385, PMCID: PMC10981729, DOI: 10.1038/s41598-024-58095-7.Peer-Reviewed Original ResearchConceptsLow-concentration sodium dodecyl sulfateAcellular scaffoldsRecellularization techniquesPerfusion-decellularizationMesenchymal stromal cellsSodium dodecyl sulfateCell attachmentRecellularization approachCo-culture of human umbilical vein endothelial cellsRecellularizationHuman umbilical vein endothelial cellsReconstructive surgeryTensor fasciae lataeExtracellular matrixRepair optionsDonor site morbidityImpact patient qualityDodecyl sulfateClinically translatable optionTensor fascia lata flapUmbilical vein endothelial cellsSoft tissue defectsPorcine flaps
2021
Intravenous Infusion of Mesenchymal Stem Cells Promotes the Survival of Random Pattern Flaps in Rats
Nakagawa T, Sasaki M, Kataoka-Sasaki Y, Yotsuyanagi T, Radtke C, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Promotes the Survival of Random Pattern Flaps in Rats. Plastic & Reconstructive Surgery 2021, 148: 799-807. PMID: 34550936, DOI: 10.1097/prs.0000000000008327.Peer-Reviewed Original ResearchConceptsMesenchymal stem cell groupStem cell groupIntravenous infusionRandom pattern flapsCell groupsMesenchymal stem cellsFlap survivalHistologic analysisRandom-pattern skin flapsBlood perfusionSurgical reconstruction optionsHigh expressionSkin flap survivalFibroblast growth factor-2 (FGF-2) mRNAQuantitative reverse transcription polymerase chain reactionStem cellsFlap survival areaReverse transcription-polymerase chain reactionSkin flap surgeryExperimental disease modelsSkin blood perfusionSkin flap modelSoft tissue defectsMasson's trichrome stainingMasson's trichrome staining results
2020
Microvascular free flap coverage for salvage of the infected total knee arthroplasty.
Lee GC, Colen DL, Levin LS, Kovach SJ. Microvascular free flap coverage for salvage of the infected total knee arthroplasty. The Bone & Joint Journal 2020, 102-B: 176-180. PMID: 32475267, DOI: 10.1302/0301-620x.102b6.bjj-2019-1661.r1.Peer-Reviewed Original ResearchConceptsInfected total knee arthroplastyTotal knee arthroplastyFree flap coverageLimb salvageFlap coverageClinical outcomesKnee arthroplastyMedian numberPersistent infectionClinical functionTissue transferKnee Society Scoring SystemMicrovascular free flap coverageTwo-stage reimplantation procedureMicrovascular free tissue transferExtensor mechanism problemsMean KSS scoreKnee prosthesisFailure of treatmentSoft tissue coverageSoft tissue defectsSoft tissue envelopeMicrovascular tissue transferFree tissue transferProsthesis reimplantation
2019
The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation
Safi AF, Schröder K, Kauke M, Safi S, Zöller JE, Zinser M. The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation. Journal Of Craniofacial Surgery 2019, Publish Ahead of Print: &na;. PMID: 30817542, DOI: 10.1097/scs.0000000000005431.Peer-Reviewed Original ResearchConceptsSoft tissue defectsPCT levelsProcalcitonin levelsSystemic inflammationMicrosurgical interventionTissue defectsPCT cutoff levelPerioperative systemic inflammationHigh mortality rateMicrovascular transplantsMicrovascular transplantationSevere complicationsSevere morbidityRetrospective studySurgical interventionTransplant lossMicrosurgical transplantationTreatment strategiesInclusion criteriaCutoff levelMortality ratePatientsReconstructive surgeonPathological levelsDetectable increase
2018
Cutaneous Breast Radiation-associated Angiosarcoma
Mella J, Ross K, Li G, Pomahac B, Raut C, Orgill D. Cutaneous Breast Radiation-associated Angiosarcoma. Plastic & Reconstructive Surgery Global Open 2018, 6: e1938. PMID: 30349797, PMCID: PMC6191213, DOI: 10.1097/gox.0000000000001938.Peer-Reviewed Original ResearchRadiation-associated angiosarcomaAbdominal advancement flapOperative timeOmental flapSkin graftsAdvancement flapPedicled latissimus dorsiAverage operative timeLength of staySplit-thickness skinLatissimus dorsi muscleSoft tissue defectsPectoralis major muscleReconstructive experienceBreast radiationRare complicationComplication rateRetrospective reviewMedian lengthBreast irradiationBreast reconstructionImmediate reconstructionIrradiated skinReconstruction flapReconstructive options
2013
Single-institution Outcome Experience Using AlloDerm® as Temporary Coverage or Definitive Reconstruction for Cutaneous and Soft Tissue Malignancy Defects
Deneve J, Turaga K, Marzban S, Puleo C, Sarnaik A, Gonzalez R, Sondak V, Zager J. Single-institution Outcome Experience Using AlloDerm® as Temporary Coverage or Definitive Reconstruction for Cutaneous and Soft Tissue Malignancy Defects. The American Surgeon 2013, 79: 476-482. PMID: 23635582, PMCID: PMC4505800, DOI: 10.1177/000313481307900522.Peer-Reviewed Original ResearchMeSH KeywordsAcellular DermisAdultAgedAged, 80 and overCarcinomaCellulitisCollagenDermatofibrosarcomaFemaleHumansMaleMelanomaMiddle AgedPlastic Surgery ProceduresPostoperative ComplicationsRetrospective StudiesSkin NeoplasmsSkin TransplantationSoft Tissue NeoplasmsSurgical FlapsTreatment OutcomeWound HealingConceptsAlloDerm reconstructionInstitutional review board-approved review of patientsDefinitive reconstructionInstitutional review board-approved reviewReview of patientsHead and neckSoft tissue malignancyMedian defect sizeSoft tissue resectionSplit-thickness skin graftEarly postoperative findingsComplex surgical defectsSoft tissue defectsAdjuvant radiationPositive marginsOral antibioticsSingle-institutionClinicopathological variablesCosmetic outcomePostoperative examinationFrequent complicationPostoperative findingsMalignant defectsSurgical defectsTissue malignancy
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