2024
Synthesis of amino-functionalized polyester via ring-opening alternating copolymerization of glycidylamines with cyclic anhydrides
Suzuki R, Gao T, Sumi A, Yamamoto T, Tajima K, Li F, Isono T, Satoh T. Synthesis of amino-functionalized polyester via ring-opening alternating copolymerization of glycidylamines with cyclic anhydrides. Polymer Chemistry 2024, 15: 3349-3358. DOI: 10.1039/d4py00715h.Peer-Reviewed Original ResearchRing-opening alternating copolymerizationCyclic anhydridesPhthalic anhydridePolymeric materialsAlkali metal carboxylatesChain extension studiesChain-growth polymerizationFunctional end groupsSide chain structurePhosphazene baseControlled/living natureMonomer scopeMetal carboxylatesEnd groupsBlock copolyestersAnhydrideSynthetic pathwayStructural diversityPolymerizationMonomerMolecular weightAntibacterial materialsPolyesterSynthesisAlcohol initiation
2004
Relationship between Side Chain Structure and 14-Helix Stability of β3-Peptides in Water
Kritzer JA, Tirado-Rives J, Hart SA, Lear JD, Jorgensen WL, Schepartz A. Relationship between Side Chain Structure and 14-Helix Stability of β3-Peptides in Water. Journal Of The American Chemical Society 2004, 127: 167-178. PMID: 15631466, PMCID: PMC2873033, DOI: 10.1021/ja0459375.Peer-Reviewed Original ResearchConceptsAlpha-helix foldingSide chain structureChain structureSolution-phase calculationsClass of foldamersSide-chain hydrogen bondingSide-chain carbonsAlpha-amino acidsHydrogen bondingΒ3‐PeptidesMacromolecular targetsChain carbonsRational designSuch moleculesConsiderable current interestDiverse functionalitiesFoldamersAlpha-helix propensityPolymersExperimental trendsAmino acidsSimilar versatilityAcidHomothreonineStructure
1992
Probing Protein Stability with Unnatural Amino Acids
Mendel D, Ellman J, Chang Z, Veenstra D, Kollman P, Schultz P. Probing Protein Stability with Unnatural Amino Acids. Science 1992, 256: 1798-1802. PMID: 1615324, DOI: 10.1126/science.1615324.Peer-Reviewed Original ResearchConceptsProtein stabilityUnnatural amino acid mutagenesisAmino acid mutagenesisUnnatural amino acidsSide-chain conformational entropyAmino acidsPosition 133T4 lysozymeHydrophobic coreConformational entropySpecific replacementChain conformational entropyMolecular modelingLeucineSide chain structureMutagenesisNorvalineSerineAcidStepwise removalEthylglycineProteinMethyl groupStructural changes
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