2022
Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Glez-Vaz J, Azpilikueta A, Olivera I, Cirella A, Teijeira A, Ochoa MC, Alvarez M, Eguren-Santamaria I, Luri-Rey C, Rodriguez-Ruiz ME, Nie X, Chen L, Guedan S, Sanmamed M, Gracia J, Melero I. Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies. Journal For ImmunoTherapy Of Cancer 2022, 10: e003532. PMID: 35236742, PMCID: PMC8896037, DOI: 10.1136/jitc-2021-003532.Peer-Reviewed Original ResearchConceptsMouse CD8 T cellsCD8 T cellsChimeric antigen receptorT cellsCD137 costimulationHuman CD137Surface expressionAnti-CD137 monoclonal antibodiesCAR-transduced T cellsCostimulatory molecule CD137Sequential plasma samplesCAR T cellsBasis of efficacyMouse tumor modelsProtein expression levelsCD137 agonistsSoluble CD137First patientSyngeneic tumorsAgonist agentsPharmacodynamic biomarkersClinical trialsPlasma concentrationsDynamic biomarkersSCD137
2016
Disease Monitoring in Multiple Myeloma Patients Using Liquid Biopsy and Next Generation Sequencing of IGH Gene Rearrangements
Gimondi S, Biancon G, Vendramin A, Zaninelli S, Rizzitano S, Malan S, Bermema A, Montefusco V, Carniti C, Corradini P. Disease Monitoring in Multiple Myeloma Patients Using Liquid Biopsy and Next Generation Sequencing of IGH Gene Rearrangements. Blood 2016, 128: 4430. DOI: 10.1182/blood.v128.22.4430.4430.Peer-Reviewed Original ResearchCell-free tumor DNAMinimal residual diseaseIgH gene rearrangementMultiple myeloma patientsTime pointsTumor burdenMyeloma patientsGene rearrangementsLiquid biopsyPlasma samplesInternational Myeloma Working Group Uniform Response CriteriaTime of CRSequential plasma samplesBone marrow infiltrationDisease monitoringResidual tumor burdenNon-invasive strategyImmunoglobulin gene rearrangementsMM ptsPresence of subclonesSpecific clonotypesProgressive diseaseMarrow infiltrationMRD monitoringResidual disease
2011
Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
Jiang C, Parrish N, Wilen C, Li H, Chen Y, Pavlicek J, Berg A, Lu X, Song H, Tilton J, Pfaff J, Henning E, Decker J, Moody M, Drinker M, Schutte R, Freel S, Tomaras G, Nedellec R, Mosier D, Haynes B, Shaw G, Hahn B, Doms R, Gao F. Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism. Journal Of Virology 2011, 85: 10669-10681. PMID: 21835785, PMCID: PMC3187499, DOI: 10.1128/jvi.05249-11.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SubstitutionApelin ReceptorsCD4-Positive T-LymphocytesCells, Culturedenv Gene Products, Human Immunodeficiency VirusGene ExpressionHIV-1HumansMacrophagesReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, HIVReceptors, LipoxinReceptors, PeptideViral TropismConceptsF virusesHuman immunodeficiency virus type 1Immunodeficiency virus type 1Alternative coreceptor GPR15Sequential plasma samplesHuman immunodeficiency virusClade B virusesVirus type 1Cell linesPrimary human CD4Third variable loopEarly time pointsCoreceptor tropismFounder virusesMultiple CD4Immunodeficiency virusAlternative coreceptorsCCR5 coreceptorPrimary infectionB virusCXCR4 coreceptorFPRL-1T cellsHuman CD4Homozygous donors
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