Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse
Stinchcombe J, Asano Y, Kaufman C, Bohlig K, Peddie C, Collinson L, Nadler A, Griffiths G. Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse. Science 2023, 380: 818-823. PMID: 37228189, PMCID: PMC7614748, DOI: 10.1126/science.abp8933.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesT cell receptorImmune synapseInduce negative membrane curvatureNegative membrane curvatureActivated T cell receptorT cell receptor signalingTarget cellsT cell receptor activationSelf-limitingOutward buddingProduction of diacylglycerolKill virus-infectedMembrane curvatureEctocytosisCancer cellsT lymphocytesDiacylglycerolEctosomesVirus infectionMembrane specializationsSynapseCellsEndocytosisKilling
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