Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes
Chmielecki J, Hutchinson K, Frampton G, Chalmers Z, Johnson A, Shi C, Elvin J, Ali S, Ross J, Basturk O, Balasubramanian S, Lipson D, Yelensky R, Pao W, Miller V, Klimstra D, Stephens P. Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes. Cancer Discovery 2014, 4: 1398-1405. PMID: 25266736, DOI: 10.1158/2159-8290.cd-14-0617.Peer-Reviewed Original ResearchConceptsPancreatic acinar cell carcinomaInactivation of DNA repair genesComprehensive genomic profilingDNA repair genesGenomic alterationsSensitive to platinum-based therapyRepair genesMEK inhibitor trametinibPlatinum-based therapyAcinar cell carcinomaPancreatic cancer diagnosisSensitive to treatmentInhibitor trametinibCell carcinomaMEK inhibitionPancreatic cancerPARP inhibitorsGenomic profilingApproximately 1%Personalized therapyRecurrent rearrangementsFrequent inactivationTumorTherapeutic targetRAF genes
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