2001
Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
Stinchcombe J, Barral D, Mules E, Booth S, Hume A, Machesky L, Seabra M, Griffiths G. Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes. Journal Of Cell Biology 2001, 152: 825-834. PMID: 11266472, PMCID: PMC2195783, DOI: 10.1083/jcb.152.4.825.Peer-Reviewed Original ResearchMeSH KeywordsActin-Related Protein 2Actin-Related Protein 3ActinsAnimalsbeta-N-AcetylhexosaminidasesCathepsin DCell MembraneCell PolarityCytoplasmic GranulesCytoskeletal ProteinsGolgi ApparatusGranzymesHermanski-Pudlak SyndromeHypopigmentationImmunologic Deficiency SyndromesMiceMice, Inbred C3HMice, Inbred C57BLMice, Mutant Strainsrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsSecretory VesiclesSerine EndopeptidasesT-Lymphocytes, CytotoxicTalinConceptsCytotoxic T lymphocytesKill target cellsImmunological synapseT lymphocytesRab geranylgeranyl transferaseTarget cellsAshen (ashLoss of function mutationsActivation of RabsSecrete granzyme ARab proteinsMembrane dockingMouse models of human diseaseAshen miceRab27a activityGeranylgeranyl transferaseModels of human diseaseRab27aRegulate secretionFunction mutationsRAB27A geneGranzyme AHuman diseasesLytic granulesMouse model
1995
Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis.
Baetz K, Isaaz S, Griffiths G. Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis. The Journal Of Immunology 1995, 154: 6122-31. PMID: 7751653, DOI: 10.4049/jimmunol.154.11.6122.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceChediak-Higashi SyndromeClone CellsCytoplasmic GranulesCytotoxicity Tests, ImmunologicExocytosisGlycoside HydrolasesGranzymesHumansImmune SeraImmunoblottingMicroscopy, FluorescenceMolecular Sequence DataReceptors, Antigen, T-CellSerine EndopeptidasesT-Lymphocytes, CytotoxicConceptsMannose-6-phosphate receptorChediak-Higashi syndromeLytic granulesCTL clonesLytic granule exocytosisAmount of killingSecrete granzyme AMannose-6-phosphateLysosomal enzyme cathepsin DGranzyme APresence of cycloheximideGranule exocytosisSynthesized proteinsEnzyme cathepsin DMembrane fusionCD8+ CTL clonesCytotoxic T lymphocyte functionLytic proteinsClonesLysosomal compartmentLoss of cytotoxicityT lymphocyte functionIndividual CTL clonesSecretory defectDestroy target cells
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