2015
When defense becomes dangerous--transcription factor Nrf2 and cancer.
Krysztofiak A, Krajka-Kuźniak V. When defense becomes dangerous--transcription factor Nrf2 and cancer. Postępy Higieny I Medycyny Doświadczalnej 2015, 69: 140-52. PMID: 25614681.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTranscription factor Nrf2Factor Nrf2Significance of Nrf2Expression of genesProtein Keap1Upstream kinaseRole of Nrf2Activation of Nrf2Nrf2 phosphorylationConformational changesBiotransformation of drugsTreatment of cancerTherapeutic effectCytoprotective enzymesDrug resistanceNrf2Adverse effectsEnzymatic systemsPhase IICancerPotential carcinogensActivationKinaseGenesPhosphorylation
2012
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine
Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. AJP Gastrointestinal And Liver Physiology 2012, 302: g925-g936. PMID: 22345550, PMCID: PMC3362073, DOI: 10.1152/ajpgi.00263.2011.Peer-Reviewed Original ResearchConceptsBile duct ligationBile acid homeostasisBile acid synthesisBile acidsLiver injuryAcid homeostasisMRNA expressionWild-type control miceBile acid transporter expressionCYP3A11 mRNA expressionBile salt export pumpBiliary bile acidsDeletion of Nrf2Bile acid reabsorptionRole of Nrf2Factor 2Bile acid hydroxylationPregnane X receptorBDL miceExpression of regulatorsControl miceDuct ligationNrf2 resultsBile secretionHepatobiliary transporters
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