Construction and Analysis of an Integrated Regulatory Network Derived from High-Throughput Sequencing Data
Cheng C, Yan KK, Hwang W, Qian J, Bhardwaj N, Rozowsky J, Lu ZJ, Niu W, Alves P, Kato M, Snyder M, Gerstein M. Construction and Analysis of an Integrated Regulatory Network Derived from High-Throughput Sequencing Data. PLOS Computational Biology 2011, 7: e1002190. PMID: 22125477, PMCID: PMC3219617, DOI: 10.1371/journal.pcbi.1002190.Peer-Reviewed Original ResearchConceptsTranscription factorsRegulatory networksGenome-wide ChIP-seqIntegrated Regulatory NetworkHigh-throughput sequencing dataTargets of miRNAsProtein-protein interactionsMulti-level regulationRNA-seq dataRNA-seq profilesHigh-throughput datasetsSet of TFsModENCODE projectHigher eukaryotesC. elegansMotif enrichmentChIP-seqRegulatory interactionsHost genesTarget genesNegative regulatorSequencing dataMiRNAsNetwork motifsConservation information
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