2014
Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2
Song W, Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Li Y, Sperling A, Rashid N, Samur M, Amin S, Tai Y, Hideshima T, Parmigiani G, Magrangeas F, Minvielle S, Avet-Loiseau H, Anderson K, Li C, Munshi N. Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2. Blood 2014, 124: 4714. DOI: 10.1182/blood.v124.21.4714.4714.Peer-Reviewed Original ResearchRNA binding proteinRNA-seq dataAlternative splicingSplicing factorsActin polymerizationCell linesNon-protein coding RNAsIsoform switchBinding proteinDiversity of transcriptomesMM cell linesRNA alternative splicingAlternative splicing eventsImportant RNA binding proteinRNA splicing factorsRNA-seq analysisPredominant nuclear localizationGene enrichment analysisCytoskeleton regulationGene regulationStromal cell interactionsSplicing eventsCoding RNAsQ-PCR analysisImportant genes
2011
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain
Sunmonu N, Li K, Li J. Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain. Journal Of Cellular Physiology 2011, 226: 1722-1726. PMID: 21506104, PMCID: PMC3071877, DOI: 10.1002/jcp.22587.Peer-Reviewed Original ResearchConceptsVertebrate developmentDevelopment of multicellular organismsSplice variantsIsoform proteinsIntegration of cell proliferationRNA alternative splicingMouse Fgf8 geneFibroblast growth factorIn vivo functionMulticellular organismsAlternative splicingFate determinationSoluble growth factorsFgf8 geneN-terminiPolypeptide growth factorsGrowth factorFgf8Ligand-receptor systemSplicingVertebratesCell proliferationFunction of FGF8IsoformsProtein
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