2023
The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity
Harrison A, Yang D, Cahoon J, Geng T, Karginov T, Torrance B, Chiari C, Haynes L, Vella A, Witczak C, Bogan J, Wang P. The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity. The Journal Of Immunology 2023, 210: 161.17-161.17. DOI: 10.4049/jimmunol.210.supp.161.17.Peer-Reviewed Original ResearchGlucose transporter 4Plasma membraneTranslocation of GLUT4Reversible posttranslational modificationRLR activationAntiviral immunityCytosolic immune sensorsVesicular traffickingPosttranslational modificationsCanonical roleCellular metabolismImmunometabolic regulationIntracellular compartmentsNovel linkTransporter 4Genetic ablationNovel mechanismImmune sensorsDistinct phenotypesLike receptorsCurrent dogmaReceptor regulationRLRIFN responseLike receptor regulation
2009
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions. Science 2009, 325: 834-840. PMID: 19608861, DOI: 10.1126/science.1175371.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAmino Acid MotifsBenzamidesCell Line, TumorCell NucleusCell Physiological PhenomenaCytoplasmEnzyme InhibitorsHistone Deacetylase InhibitorsHistone DeacetylasesHumansHydroxamic AcidsLysineMass SpectrometryMetabolic Networks and PathwaysMitochondriaMultiprotein ComplexesProtein Processing, Post-TranslationalProtein Structure, TertiaryProteinsProteomeProteomicsPyridinesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVorinostatConceptsLysine acetylationCellular rolesPosttranslational modificationsCyclin-dependent kinase Cdc28Phosphorylation-dependent interactionReversible posttranslational modificationDiverse cellular processesMajor cellular functionsTarget protein complexesMajor posttranslational modificationLarge macromolecular complexesLysine acetylation sitesChromatin remodelingActin nucleationNuclear transportProtein complexesCellular functionsCellular processesAcetylation sitesMacromolecular complexesAcetylation changesGene expressionCell cycleDeacetylase inhibitorsAcetylation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply