2019
Fibroblast Growth Factor Receptor 3 Alterations and Response to PD-1/PD-L1 Blockade in Patients with Metastatic Urothelial Cancer
Wang L, Gong Y, Saci A, Szabo P, Martini A, Necchi A, Siefker-Radtke A, Pal S, Plimack E, Sfakianos J, Bhardwaj N, Horowitz A, Farkas A, Mulholland D, Fischer B, Oh W, Sharma P, Zhu J, Galsky M. Fibroblast Growth Factor Receptor 3 Alterations and Response to PD-1/PD-L1 Blockade in Patients with Metastatic Urothelial Cancer. European Urology 2019, 76: 599-603. PMID: 31272788, PMCID: PMC6801024, DOI: 10.1016/j.eururo.2019.06.025.Peer-Reviewed Original ResearchConceptsT cell infiltrationUrothelial cancerFGFR3 mutationsAssociated with decreased T-cell infiltrationFGFR3 alterationsResponse to PD-1/PD-L1 blockadeLow T-cell infiltrationPD-1/PD-L1 inhibitionPoor T-cell infiltrationPD-1/PD-L1 blockadeResponse rateMetastatic urothelial cancerSingle-agent activityPD-1/PD-L1Tumor mutational burdenNon-cross-resistantTumors harboring mutationsFGFR3 mutation statusHypothesis-generating dataSimilar to patientsResponse to treatmentBiomarkers of resistanceGrowth factor-betaStatistically significant differenceMetastatic UC
2018
EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
Wang L, Saci A, Szabo P, Chasalow S, Castillo-Martin M, Domingo-Domenech J, Siefker-Radtke A, Sharma P, Sfakianos J, Gong Y, Dominguez-Andres A, Oh W, Mulholland D, Azrilevich A, Hu L, Cordon-Cardo C, Salmon H, Bhardwaj N, Zhu J, Galsky M. EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer. Nature Communications 2018, 9: 3503. PMID: 30158554, PMCID: PMC6115401, DOI: 10.1038/s41467-018-05992-x.Peer-Reviewed Original ResearchConceptsUrothelial cancerT cellsEMT-related gene expressionPD-1Response to PD-1/PD-L1 blockadeResistance to PD-1 blockadePD-1/PD-L1 blockadeNon-hematopoietic stromal cellsAssociated with lower response ratesMetastatic urothelial cancerPD-1 blockadePD-1 inhibitorsShorter progression-freeT cell infiltrationCohort of patientsT cell abundanceGene expressionEpithelial-mesenchymal transition (EMT)-related gene expressionProgression-FreeOverall survivalPrognostic informationStromal elementsTumor typesCancer Genome AtlasImmune resistance
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