1993
Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene.
Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Endocrinology 1993, 7: 273-82. PMID: 8469240, DOI: 10.1210/mend.7.2.8469240.Peer-Reviewed Original ResearchConceptsExon 1cPeptide genesGC-rich promoter elementsCis-regulatory sequencesHuman parathyroid hormone-related peptide geneGC-rich promoterHandful of genesPrimer extension analysisHuman renal carcinoma cellsCanonical TATARenal carcinoma cellsFunctional dissectionCAAT sequencesHuman PTHrP genePutative promoterDNA 5Regulatory sequencesExtension analysisPromoter elementsGene promoterCAT geneGenomic DNAExon 1AAcetyltransferase constructsPrimer extension
1992
Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types.
Soifer NE, Dee KE, Insogna KL, Burtis WJ, Matovcik LM, Wu TL, Milstone LM, Broadus AE, Philbrick WM, Stewart AF. Parathyroid hormone-related protein. Evidence for secretion of a novel mid-region fragment by three different cell types. Journal Of Biological Chemistry 1992, 267: 18236-18243. PMID: 1517251, DOI: 10.1016/s0021-9258(19)37178-9.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinoma, Renal CellCell LineElectrophoresis, Polyacrylamide GelFluorescent Antibody TechniqueHumansImmunohistochemistryKidney NeoplasmsKineticsMolecular Sequence DataParathyroid HormoneParathyroid Hormone-Related ProteinPeptide FragmentsProtein BiosynthesisProteinsTransfectionConceptsMid-region fragmentCell typesSecretory formBasic amino acid motifHormone-related proteinAmino acid motifsImportant biological functionsAmino acid sequenceExtensive post-translational processingPost-translational processingDifferent cell typesHuman renal carcinoma cellsInterspecies conservationSodium dodecyl sulfate-polyacrylamide gel electrophoresis analysisRenal carcinoma cellsAcid motifGel electrophoresis analysisAcid sequenceBiological functionsParathyroid hormone-related proteinRegion-specific immunoassaysRat insulinoma cellsCell extractsCleavage siteAmino acids
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