2001
Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks
Belperron A, Bockenstedt L. Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks. Infection And Immunity 2001, 69: 6456-6462. PMID: 11553590, PMCID: PMC98781, DOI: 10.1128/iai.69.10.6456-6462.2001.Peer-Reviewed Original ResearchConceptsB cell-deficient miceNatural antibodiesControl miceConfocal immunofluorescence microscopySalivary glandsEarly host defenseBlood-sucking vectorsMammalian hostsFeeding ticksB. burgdorferi organismsNormal mouse serumTick midgutAbsence of exposureOuter surface protein AArthropod vectorsImmunofluorescence microscopyMammalian seraSurface protein ASpirochete Borrelia burgdorferiPolyclonal immunoglobulin MPathogen transmissionSpirochete burdenPassive transferBlood mealImmunoglobulin M
1994
Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice
Nguyen TP, Lam TT, Barthold SW, Telford SR, Flavell RA, Fikrig E. Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infection And Immunity 1994, 62: 2079-2084. PMID: 8168973, PMCID: PMC186469, DOI: 10.1128/iai.62.5.2079-2084.1994.Peer-Reviewed Original ResearchConceptsEarly-stage disease patientsMajority of patientsLate-stage diseaseSerum of miceLyme disease vaccineB. burgdorferiB. burgdorferi organismsExamination of seraNumber of spirochetesOuter surface protein ESyringe challengeDisease patientsImmune responseDisease vaccinePatientsHigh titersLyme diseaseMiceAntibodiesDiseaseSerumBurgdorferiBorreliaDaysProtein E
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