A LAIR-1 targeting antibody drug conjugate for hematologic cancers.
Flies D, Barbu E, Kothari P, Kahan S, Maloveste S, Wilcox R, Kim T, Guha U, Langermann S, Panneer Selvam S, Lovewell R. A LAIR-1 targeting antibody drug conjugate for hematologic cancers. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e15022.Peer-Reviewed Original ResearchAntibody drug conjugatesLAIR-1 expressionLAIR-1Hematological cancersTumor cellsKnock-in (KI) miceControl of tumorsDrug conjugatesT-cell lymphomaHematopoietic cell subsetsImmune cell populationsKilling of leukemic cellsRegulate immune activationAnti-tumor activityExpressed high levelsLeukemic cell deathInternalization in vitroIn vitro cytotoxicity assayLymphoma tumorsTumor cell linesCell subsetsImmune activationLymphoma cellsLymphomaTumor model
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