2008
Prioritization of gene regulatory interactions from large-scale modules in yeast
Lee HJ, Manke T, Bringas R, Vingron M. Prioritization of gene regulatory interactions from large-scale modules in yeast. BMC Bioinformatics 2008, 9: 32. PMID: 18211684, PMCID: PMC2244593, DOI: 10.1186/1471-2105-9-32.Peer-Reviewed Original ResearchConceptsTranscriptional modulesRegulatory interactionsTarget genesTranscription factorsChIP-chip binding dataTF-gene interactionsGene regulatory interactionsCo-regulated proteinsCo-regulated genesNormal growth conditionsGenome-wide dataCell wall synthesisChIP-chip dataRegulatory linkWall synthesisFunctional categoriesRegulatory proteinsYeast dataGenesCoherent modulesGrowth conditionsProteinBiological systemsDifferent reference datasetsNumerous modules
2006
Characterizing disease states from topological properties of transcriptional regulatory networks
Tuck DP, Kluger HM, Kluger Y. Characterizing disease states from topological properties of transcriptional regulatory networks. BMC Bioinformatics 2006, 7: 236. PMID: 16670008, PMCID: PMC1482723, DOI: 10.1186/1471-2105-7-236.Peer-Reviewed Original ResearchConceptsTranscriptional regulatory networksRegulatory networksTranscription factorsTranscriptional networksRegulated genesGene deregulationExpression profilesDiseased statesGene regulatory networksCentrality of genesGene expression experimentsGene expression profilesGene expression studiesGene centralityRegulatory linkExpression experimentsExpression studiesGene linksGenesCell typesExpression datasetsGene subsetsDifferential activityNormal cellsRemarkable degree
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