The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder
Bosse G, Cadeddu R, Floris G, Farero R, Vigato E, Lee S, Zhang T, Gaikwad N, Keefe K, Phillips P, Bortolato M, Peterson R. The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder. Journal Of Clinical Investigation 2021, 131 PMID: 33848264, PMCID: PMC8121512, DOI: 10.1172/jci143990.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid Self-AdministrationDehydroepiandrosterone sulfateSelf-AdministrationRat model of neuropathic painModel of neuropathic painTreatment of benign prostatic hyperplasiaUse disorderPotential of finasterideReduced self-administrationSelf-administration assayWithdrawal-induced hyperalgesiaBenign prostatic hyperplasiaEffects of finasterideSource of therapeutic targetsNeuropathic painOpioid withdrawalInhibitor finasterideSteroidogenesis inhibitorsProstatic hyperplasiaAntinociceptive effectTreatment optionsRat modelFinasterideMultiple opioids
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