Xilin Shen, PhD
Research Scientist in Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease
Abuwarda H, Trainer A, Horien C, Shen X, Moret S, Ju S, Constable R, Fredericks C. Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease. Brain Communications 2025, 7: fcaf274. PMID: 40735265, PMCID: PMC12305425, DOI: 10.1093/braincomms/fcaf274.Peer-Reviewed Original ResearchAlzheimer's disease pathologyAlzheimer's diseaseTau elevationTau-PET signalTau-PETTau modelDisease pathologyAbnormal accumulationPreclinical Alzheimer's diseaseAmyloid-bWhole-brain FCTau pathologyAssociated with tauFunctional connectivityRegional tauTauFunctional connectomeFC-based modelsWhole-brainPET signalAlzheimerConnectome-based predictive modelingWhole-brain functional connectivityDisease clinical spectrumTarget regionYale Brain Atlas to interactively explore multimodal structural and functional neuroimaging data
Collins E, Chishti O, McGrath H, Obaid S, King A, Qiu E, Gabriel E, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Yale Brain Atlas to interactively explore multimodal structural and functional neuroimaging data. Frontiers In Network Physiology 2025, 5: 1585019. PMID: 40607320, PMCID: PMC12217586, DOI: 10.3389/fnetp.2025.1585019.Peer-Reviewed Original ResearchMultimodal neuroimaging dataNeuroimaging dataAnalysis of multimodal neuroimaging dataBrain structure-function relationshipsFunctional neuroimaging dataFMRI activation dataWhite matter connectomeHuman Connectome ProjectBrain atlasesCortical thickness profilesConnectome ProjectHuman brainAnatomical parcellationBrainConnectivity matrixAtlas spaceYaleInteractive explorationHealthy subjectsWeb toolCognitionInteractive pagesEmotionsSubjectsConnectomeSimultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease
Mandino F, Shen X, Fredericks C, Strittmatter S, Lake E. Simultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0828.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingProdromal Alzheimer's diseaseBOLD fMRIAlzheimer's diseaseAD-related cognitive impairmentBlood oxygen levelAD-related changesMonths-of-ageModality-specificNetwork dysfunctionFemale wild-typeCognitive impairmentYoung adulthoodProdromal ADWild-typeCortical connectivityMagnetic resonance imagingNetwork disruptionAD miceSex-specific differencesSex-based differencesResonance imagingAnimal modelsLifetime riskBOLDNeural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI.
Mandino F, Horien C, Shen X, Papademetris X, Keilholz S, Xu N, Lake E. Neural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1012.Peer-Reviewed Original ResearchQuasi-periodic patternsBOLD fMRIMeasured whole brain activityBOLD fMRI dataCross-modal agreementWhole-brain activityDynamic activity patternsNeural underpinningsSpatiotemporal structureBOLD signalCalcium imagingFluorescence calcium imagingLow-frequencyBrain activityNeural activityCortical activitySubject levelFMRIActivity patternsBOLDNeural originInter-subject variabilityMultimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI
Mandino F, Horien C, Shen X, Desrosiers-Grégoire G, Luo W, Markicevic M, Constable R, Papademetris X, Chakravarty M, Betzel R, Lake E. Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI. Communications Biology 2025, 8: 665. PMID: 40287579, PMCID: PMC12033268, DOI: 10.1038/s42003-025-08037-4.Peer-Reviewed Original ResearchConceptsBOLD fMRIBOLD fMRI dataConnectome-based identificationCognitive neuroscientistsFMRI literatureHeterogeneous neurological conditionsWhole cortexFMRIMouse brainSimultaneous Ca2+ imagingCa2+ imagingAnimal modelsFluorescence calcium imagingCalcium imagingNeurological conditionsPersonalized treatmentNeuroimagingBOLDCortexNeuroscientistsBrainMiceMultimodal identificationCell-type specific signalsWhole-brain functional connectivity predicts tau PET in preclincal Alzheimer’s disease (N4.002)
Abuwarda H, Trainer A, Horien C, Shen X, Ju S, Constable T, Fredericks C. Whole-brain functional connectivity predicts tau PET in preclincal Alzheimer’s disease (N4.002). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000210639.Peer-Reviewed Original ResearchPREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES
Sankar *, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. PREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES. The International Journal Of Neuropsychopharmacology 2025, 28: i15-i15. PMCID: PMC11814904, DOI: 10.1093/ijnp/pyae059.027.Peer-Reviewed Original ResearchConnectome-based predictive modelingBipolar disorderMood symptomatologyMood symptomsFunctional connectomeYoung Mania Rating ScaleFunctional magnetic resonance imaging dataPredictors of functional impairmentEmotion processing taskMania Rating ScaleMood symptom severityMood symptom scoresBrain functional connectomeMagnetic resonance imaging dataBrain function disturbancesHamilton DepressionPredicting DepressionSymptom severityRating ScaleFunctional impairmentDisordersMoodSymptomatologyProcessing tasksDepression
2024
Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Mandino F, Shen X, Desrosiers-Grégoire G, O’Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty M, Strittmatter S, Lake E. Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator. Molecular Psychiatry 2024, 30: 1730-1745. PMID: 39424929, PMCID: PMC12015114, DOI: 10.1038/s41380-024-02779-z.Peer-Reviewed Original ResearchFunctional connectivity deficitsConnectivity deficitsFunctional connectivityBrain connectivityAllosteric modulators of mGluR5Alzheimer's diseaseDefault-mode networkModulation of mGluR5Loss of functional connectivityResting-state fMRIApplication of fMRIWild-type controlsAged AD miceMouse model of Alzheimer's diseaseAD-related changesAD miceModel of Alzheimer's diseaseAssociated with synaptic damageMGluR5 modulationMonths of ageFMRI measurementsAmyloid accumulationDecreased connectivityBrain networksSilent allosteric modulatorsRepetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024, 41: 2528-2544. PMID: 39096127, PMCID: PMC11698675, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanismsMapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositories
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