PET Core

Housed under the Yale Bioimaging Institute, the PET core is a revenue-neutral (fee-for-service) inter-institutional service provider.

The Yale PET Core is an FDA-registered radiotracer manufacturing and imaging facility that supports molecular imaging research. It conducts over 1,000 human scans and 300 small animal scans annually, supporting more than 120 clinical research and 11 animal imaging protocols across 21 departments. The core is a key resource for NIH-funded research at Yale and throughout New England. Equipped with a GE PETtrace cyclotron, radiochemistry lab developing PET radiopharmaceuticals with common isotopes (11C, 15O, 13N, 18F), and eight PET scanners dedicated to research, the facility includes systems for both human and preclinical studies. The PET Core's experienced staff enables investigators to perform advanced PET research, even without full technical expertise.

Positron Emission Tomography (PET) is a non-invasive diagnostic scanning technique that provides visual images of organ function (including blood flow, oxygen consumption, glucose metabolism, and concentrations of molecules in the brain and body tissues). During the scanning process, small amounts of radioactive compounds are injected into the body where they are absorbed by organs and tissues. The PET scanner picks up signals from the radioactive tracers and detects biochemical changes in metabolic processes that aid in disease diagnosis. Other diagnostic techniques such as CT and MRI scans can only detect structural changes after tissue damage has occurred.

Disease Diagnosis

PET scans are utilized to diagnose heart disease, brain tumors, stroke, cancer, epilepsy, head injuries, Parkinson’s disease, and many other disorders. By measuring blood flow to the heart, PET scans can be used to diagnose disorders such as coronary artery disease. PET scans can also help to determine the extent of muscle damage caused by a heart attack. One of the most significant advantages of PET is its ability to detect biochemical changes in body tissues before structural damage occurs from disease. This information allows clinicians to be proactive in their treatments.

Treatment Monitoring

Clinicians use PET scans to measure the effectiveness of current disease treatments. Scans taken at various intervals during drug therapy can demonstrate whether the medication is working, or if the treatment should be modified. Post-treatment scans evaluate the effectiveness of the treatment and can also identify early signs of disease recurrence.

Research

Research scientists use PET scans to study brain activity and chemical mechanisms involved in diseases such as schizophrenia, depression, Alzheimer’s disease, alcohol dependence, and substance abuse. By studying tissue concentrations of the absorbed radiotracer, scientists can determine if the tracer is effectively reaching molecular targets. This information can aid scientists in the development of new medications and dosing regimens.

A radioactive tracer is produced in a cyclotron machine, attached to a naturally occurring body compound (such as glucose), and administered to the patient intravenously. The tracer is absorbed by the body and concentrates in tissues and organs.

The patient lies on a table that slides slowly through a PET scanner. As the patient slides through the circular opening of the scanner, the tracer emits radioactive signals. These signals are recorded by multiple rings of detectors in the scanner and are converted into three-dimensional computer images of tissue concentrations and organ function.

Levels of tissue concentrations and organ function are represented by different colors or degrees of brightness on computer-generated PET images. Some radioactive tracer will be seen in normal tissues because healthy tissues use glucose for energy. Cancerous tumors utilize more glucose than normal tissues and will appear much brighter.

Once the scanning session has been completed, a specially trained radiologist will interpret the scan, record their findings, and forward this information to the referring physician to discuss with their patient.

• Identifies early biochemical markers of disease before structural changes in body organs occur.
• Provides an opportunity for earlier and more specific diagnosis, intervention, and treatment of disease. (CT and MRI detect structural changes after damage has occurred).
• Enables researchers to detect early biomarkers of disease that can aid in drug development.

With our staff of APRNs, RNs, NMTs, and MDs, we offer a full spectrum of clinical services for PET research inside and outside the medical school for projects enrolling human subjects.

• PET Scans (for humans, large and small animals)
• Radiosynthesis
• Validation
• Pharmacokinetic study
• Metabolite analysis
• Blood sampling
• Regulatory filing
• NHP usage
• Medical services (a-line placement, EKG, health & physical intake)

Initial phase

• Review all protocols
• Coordinate clinical resources internally and externally
• Develop study-specific procedures
• Provide clinical training to staff.

Active Enrollment Phase

• RAs ensure proper subject selection for individual protocols with medical coverage, care, guidance, and consultation.
• Screenings with physical examination and medical clearance
• Coverage/supervision of PET scans of over 50 different radioligands
• Inpatient hospitalization and monitoring through the Clinical Research Unit at YNHH and the Clinical Neuroscience Research Unit at CMHC
• Medical administration and supervision of pharmacologically active compounds

Our subject population is diverse, including cancer patients undergoing chemotherapy treatment, individuals with psychiatric conditions, and patients with neurological disorders such as Parkinson’s disease, epilepsy, and multiple system atrophy. Clinical research at the Yale Biomedical Imaging Institute adheres to Good Clinical Practices (GCP) in all human studies.

Please review the documents linked below for detailed instructions and forms

• PET Core Human Study Policy
• PET Investigators Guide 2020-08
• PET Investigators Guide Addendum-Forms-2019-01
• PET Investigators Guide Grant Info-2022-07
• PET Core Protocol Initiation Form

Scan availability can be found on our monthly calendars. Contact Samantha Massaro (samantha.massaro@yale.edu) for access.