2016
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking
Wang S, Kim S, Cosgrove KP, Morris ED. A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking. NeuroImage 2016, 146: 701-714. PMID: 27743899, PMCID: PMC5321849, DOI: 10.1016/j.neuroimage.2016.10.019.Peer-Reviewed Original ResearchConceptsNeurotransmitter responsesCigarette smokingDrug stimuliDA releaseDA activationBolus injectionMild shorteningPET scansOptimal timingSmokingDopamine responsePET dataLp-ntPETDose limitTime courseSex differencesScansLoss of sensitivityBehavioral tasksDrugsLinear parametric neurotransmitter PETLower dose limitSuch responsesResponseStimuli
2013
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking. Journal Of Visualized Experiments 2013, 50358. PMID: 23963311, PMCID: PMC4046621, DOI: 10.3791/50358.Peer-Reviewed Original ResearchConceptsStatistical stepsTime-varying parametersTime-varying functionModel parametersSpatial filterDecomposition techniqueKinetic model parametersConventional modelsSpatial noiseFluctuationsNew modelParametersAnalysis techniquesLp-ntPETModelConventional methodsStatistical comparisonMain stepsDynamic PET data