Santosh Reddy Alluri
Associate Research ScientistCards
About
Research
Publications
2024
A protocol for controlled reactivity shift in the 2,2-difluorovinyl motif used for selective S-(18)F and C-(18)F bond formation.
Maqbool M, Jakobsson JE, Alluri SR, Kramer V, Riss PJ. A protocol for controlled reactivity shift in the 2,2-difluorovinyl motif used for selective S-(18)F and C-(18)F bond formation. Commun Chem 2024, 7: 97. PMID: 38684771, DOI: 10.1038/s42004-024-01132-3.Peer-Reviewed Original Research
2023
Evaluation of a First PET Tracer Suitable for Imaging the Sigma‑2 Receptor in the Brain of Nonhuman Primates
Alluri S, Zheng M, Holden D, Zhang Y, Zhang L, Felchner Z, Li S, Ropchan J, Carson R, Jia H, Huang Y. Evaluation of a First PET Tracer Suitable for Imaging the Sigma‑2 Receptor in the Brain of Nonhuman Primates. Molecular Pharmaceutics 2023, 21: 194-200. PMID: 38013422, DOI: 10.1021/acs.molpharmaceut.3c00750.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseLimited brain uptakeNonhuman primate brainCentral nervous systemPotential therapeutic targetPositron emission tomography (PET) imagingEmission Tomography ImagingTransmembrane protein 97Sigma-2 receptorsFirst PET tracerBrain penetrantBrain uptakeTherapeutic targetNervous systemPrimate brainNeurological disordersPET tracersNonhuman primatesTomography imagingProtein 97CancerDiseaseBrainCell typesReceptorsSynthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis.
Alluri SR, Higashi Y, Berendzen A, Grisanti LA, Watkinson LD, Singh K, Hoffman TJ, Carmack T, Devanny EA, Tanner M, Kil KE. Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis. Res Sq 2023 PMID: 36865232, DOI: 10.21203/rs.3.rs-2539952/v1.Peer-Reviewed Original Research
2022
Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors.
Alluri S, Eisenberg SM, Grisanti LA, Tanner M, Volkow ND, Kim SW, Kil KE. Preclinical evaluation of new C-11 labeled benzo-1,4-dioxane PET radiotracers for brain α2C adrenergic receptors. Eur J Med Chem 2022, 243: 114764. PMID: 36272201, DOI: 10.1016/j.ejmech.2022.114764.Peer-Reviewed Original Research
2021
PET Imaging Radiotracers of Chemokine Receptors.
Alluri SR, Higashi Y, Kil KE. PET Imaging Radiotracers of Chemokine Receptors. Molecules 2021, 26 PMID: 34500609, DOI: 10.3390/molecules26175174.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives.
Alluri SR, Kim SW, Volkow ND, Kil KE. PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives. Molecules 2020, 25 PMID: 32899124, DOI: 10.3390/molecules25174017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSynthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[(18) F]fluoro-L-amino suberate.
Alluri SR, Pitman KE, Malinen E, Riss PJ. Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[(18) F]fluoro-L-amino suberate. J Labelled Comp Radiopharm 2020, 63: 6-14. PMID: 31697846, DOI: 10.1002/jlcr.3814.Peer-Reviewed Original Research
2019
Influx rate of (18)F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts.
Pitman KE, Alluri SR, Kristian A, Aarnes EK, Lyng H, Riss PJ, Malinen E. Influx rate of (18)F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts. Eur J Nucl Med Mol Imaging 2019, 46: 2190-2198. PMID: 31264167, DOI: 10.1007/s00259-019-04375-8.Peer-Reviewed Original Research
2018
Poly(ADP-ribose) Polymerase in Neurodegeneration: Radiosynthesis and Radioligand Binding in ARC-SWE tg Mice.
Alluri SR, Riss PJ. Poly(ADP-ribose) Polymerase in Neurodegeneration: Radiosynthesis and Radioligand Binding in ARC-SWE tg Mice. ACS Chem Neurosci 2018, 9: 1259-1263. PMID: 29544053, DOI: 10.1021/acschemneuro.8b00053.Peer-Reviewed Original ResearchStereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography.
Alluri SR, Riss PJ. Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography. Org Biomol Chem 2018, 16: 2219-2224. PMID: 29546903, DOI: 10.1039/C8OB00184G.Peer-Reviewed Original Research
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PET Core
138 Magnetic resonance center, Yale PET center
New Haven, CT 06519
United States