2020
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake EMR, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT. Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI. Nature Methods 2020, 17: 1262-1271. PMID: 33139894, PMCID: PMC7704940, DOI: 10.1038/s41592-020-00984-6.Peer-Reviewed Original ResearchConceptsOptical measurementsBrain functionTransgenic murine modelFunctional magnetic resonance imagingMagnetic resonance imagingFluorescent measuresWhole-brain fMRIMurine modelResonance imagingFluorescence Ca2Human brain functionConnectivity strengthBOLD signalBrain activityWidefieldLow frequencyImagingModalitiesTransfer functionMeasurementsCortex
2018
Functional Magnetic Resonance Imaging-Based Neurofeedback Training in Patients with Parkinson’s Disease (P3.075)
Tinaz S, Nalamada K, Sezgin M, Vives-Rodriguez A, Para K, Scheinost D, Louis E, Hampson M. Functional Magnetic Resonance Imaging-Based Neurofeedback Training in Patients with Parkinson’s Disease (P3.075). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p3.075.Peer-Reviewed Original Research
2017
Fine Motor Skill Mediates Visual Memory Ability with Microstructural Neuro-correlates in Cerebellar Peduncles in Prematurely Born Adolescents
Thomas AR, Lacadie C, Vohr B, Ment LR, Scheinost D. Fine Motor Skill Mediates Visual Memory Ability with Microstructural Neuro-correlates in Cerebellar Peduncles in Prematurely Born Adolescents. Cerebral Cortex 2017, 27: 322-329. PMID: 28108493, PMCID: PMC5939198, DOI: 10.1093/cercor/bhw415.Peer-Reviewed Original ResearchConceptsGrooved Pegboard TestFine motor skillsVisual-motor integrationRey-Osterrieth Complex Figure TestCerebellar peduncleFractional anisotropyBrain injuryGPT scoresMotor skillsBilateral middle cerebellar pedunclesNeonatal brain injuryDiffusion-weighted magnetic resonance imagingRight superior cerebellar peduncleAge 16 yearsSuperior cerebellar peduncleMiddle cerebellar peduncleBeery Visual Motor IntegrationMagnetic resonance imagingRisk of deficitsWhite matter microstructurePegboard TestPretermResonance imagingComplex Figure TestTerm controls
2016
Fluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks
Scheinost D, Tokoglu F, Shen X, Finn ES, Noble S, Papademetris X, Constable RT. Fluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks. IEEE Transactions On Biomedical Engineering 2016, 63: 2540-2549. PMID: 27541328, PMCID: PMC5180443, DOI: 10.1109/tbme.2016.2600248.Peer-Reviewed Original ResearchConceptsGlobal brain activityResting-state networksWhole-brain connectivityBrain activityResting-state functional magnetic resonance imagingTime pointsFunctional resting-state networksFunctional magnetic resonance imagingMagnetic resonance imagingResting-state studyBrain statesRSN connectivitySensory functionSubcortical regionsResonance imagingCognitive functionCoactivation patternsUnique brain statesBrain connectivityActivity stateCritical time pointsFunctional networksSignal intensityVoxel-based methodBrain dynamicsPrenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, Ment LR. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clinical 2016, 12: 381-388. PMID: 27622134, PMCID: PMC5009231, DOI: 10.1016/j.nicl.2016.08.010.Peer-Reviewed Original ResearchConceptsPrenatal stress exposurePreterm neonatesPreterm birthPrenatal stressStress exposureTerm controlsFunctional connectivityAmygdala connectivityNeuropsychiatric disordersResting-state functional magnetic resonance imagingPrenatal stress altersEarly life stressFunctional magnetic resonance imagingMagnetic resonance imagingPeristriate cortexPrenatal exposureHigh riskMaternal stressIndependent cohortNeonatesLeft amygdalaSubcortical regionsResonance imagingAmygdalaCohort
2015
Preterm birth alters neonatal, functional rich club organization
Scheinost D, Kwon SH, Shen X, Lacadie C, Schneider KC, Dai F, Ment LR, Constable RT. Preterm birth alters neonatal, functional rich club organization. Brain Structure And Function 2015, 221: 3211-3222. PMID: 26341628, PMCID: PMC4779074, DOI: 10.1007/s00429-015-1096-6.Peer-Reviewed Original ResearchConceptsPT neonatesTerm neonatesRich-club organizationPreterm birth altersTerm-equivalent ageClub organizationFunctional magnetic resonance imagingMagnetic resonance imagingPT birthBirth altersWhole-brain networksNeonatesResonance imagingPretermFunctional connectivityFunctional segregationCognitive difficultiesEquivalent ageFunctional organizationBrain
2014
The impact of image smoothness on intrinsic functional connectivity and head motion confounds
Scheinost D, Papademetris X, Constable RT. The impact of image smoothness on intrinsic functional connectivity and head motion confounds. NeuroImage 2014, 95: 13-21. PMID: 24657356, PMCID: PMC4076413, DOI: 10.1016/j.neuroimage.2014.03.035.Peer-Reviewed Original ResearchConceptsResting-state functional magnetic resonance imagingWhole-brain functional organizationFunctional magnetic resonance imagingIntrinsic functional connectivityMagnetic resonance imagingFunctional connectivity studiesResonance imagingRs-fMRIFunctional connectivityClinical populationsGroup differencesConnectivity studiesHead motionFunctional organizationHead movementsRecent studies