2023
Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among children
Lin H, Haider S, Kaltenhauser S, Mozayan A, Malhotra A, Constable R, Scheinost D, Ment L, Konrad K, Payabvash S. Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among children. Frontiers In Neuroscience 2023, 17: 1138670. PMID: 36908780, PMCID: PMC9992191, DOI: 10.3389/fnins.2023.1138670.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderADHD diagnosisHyperactivity disorderChildhood attention deficit hyperactivity disorderAssociation of ADHDDorsal attention networkFunctional MRI studyDefault mode networkResting-state fMRIADHD childrenAttention functionLimitations of machineAttention networkFrontal regionsNeuroimaging datasetsNeurobiological implicationsParietal lobeFrontal lobe cortexCortical volumeFractional anisotropyFunctional neuroimaging datasetsChildrenWhite matter tractsNeurite densityMicrostructural integrity
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2019
The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder
Lake EMR, Finn ES, Noble SM, Vanderwal T, Shen X, Rosenberg MD, Spann MN, Chun MM, Scheinost D, Constable RT. The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2019, 86: 315-326. PMID: 31010580, PMCID: PMC7311928, DOI: 10.1016/j.biopsych.2019.02.019.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAutism spectrum disorderSpectrum disorderFunctional connectivity profilesHyperactivity disorderBrain organizationAutism Brain Imaging Data ExchangeConnectome-based predictive modelingAutism Diagnostic Observation ScheduleAutism spectrum disorder traitsAutism spectrum disorder severitySocial Responsiveness Scale scoresADHD Rating Scale scoresFunctional magnetic resonance imagingBrain-behavior associationsSocial Responsiveness ScaleResting-state functional magnetic resonanceFunctional brain organizationFunctional magnetic resonanceADHD traitsNeurofunctional basisADHD symptomsSplit-half analysisResponsiveness ScaleSocial abilities
2017
Characterizing Attention with Predictive Network Models
Rosenberg MD, Finn ES, Scheinost D, Constable RT, Chun MM. Characterizing Attention with Predictive Network Models. Trends In Cognitive Sciences 2017, 21: 290-302. PMID: 28238605, PMCID: PMC5366090, DOI: 10.1016/j.tics.2017.01.011.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAttentional abilitiesLarge-scale brain networksLaboratory-based tasksDeficit hyperactivity disorderExplicit taskCognitive abilitiesHyperactivity disorderBrain networksBrain computationCognitive functionFunctional connectivityFunctional architectureTaskClinical dysfunctionEmpirical evidenceAttentionPredictive network modelsNeuromarkersNetwork modelAbilityRecent workNetwork propertiesDisordersPeople
2016
Does prenatal stress alter the developing connectome?
Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Does prenatal stress alter the developing connectome? Pediatric Research 2016, 81: 214-226. PMID: 27673421, PMCID: PMC5313513, DOI: 10.1038/pr.2016.197.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderStress-related symptomsPrenatal exposureRisk factorsMajor depressionFetal brainMaternal stressPrenatal stressNeural elementsNeurobehavioral disordersFunctional connectivityHyperactivity disorderHuman neurodevelopmentDisordersAutism spectrum disorderFunctional networksConnectomeSpectrum disorderHuman connectomePregnancySymptomsNeurodevelopmentSchizophreniaBrainMethylphenidate Modulates Functional Network Connectivity to Enhance Attention
Rosenberg MD, Zhang S, Hsu WT, Scheinost D, Finn ES, Shen X, Constable RT, Li CS, Chun MM. Methylphenidate Modulates Functional Network Connectivity to Enhance Attention. Journal Of Neuroscience 2016, 36: 9547-9557. PMID: 27629707, PMCID: PMC5039242, DOI: 10.1523/jneurosci.1746-16.2016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSustained attentionWhole-brain connectivity patternsFunctional brain networksHyperactivity disorderBrain networksConnectivity patternsConnectome-based predictive modeling approachWhole-brain functional connectivity patternsWhole-brain functional connectivity networksSustained attention taskStop-signal taskDose of methylphenidateFunctional network connectivityCausal roleFunctional connectivity patternsHealthy adultsAttention taskCognitive abilitiesPromising neuromarkerNetwork strengthBehavioral predictionsADHD treatmentConnectivity signaturesFunctional connectivity networks