2019
Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback interventionThe Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder
Lake EMR, Finn ES, Noble SM, Vanderwal T, Shen X, Rosenberg MD, Spann MN, Chun MM, Scheinost D, Constable RT. The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2019, 86: 315-326. PMID: 31010580, PMCID: PMC7311928, DOI: 10.1016/j.biopsych.2019.02.019.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAutism spectrum disorderSpectrum disorderFunctional connectivity profilesHyperactivity disorderBrain organizationAutism Brain Imaging Data ExchangeConnectome-based predictive modelingAutism Diagnostic Observation ScheduleAutism spectrum disorder traitsAutism spectrum disorder severitySocial Responsiveness Scale scoresADHD Rating Scale scoresFunctional magnetic resonance imagingBrain-behavior associationsSocial Responsiveness ScaleResting-state functional magnetic resonanceFunctional brain organizationFunctional magnetic resonanceADHD traitsNeurofunctional basisADHD symptomsSplit-half analysisResponsiveness ScaleSocial abilities
2018
Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s Disease
Tinaz S, Para K, Vives-Rodriguez A, Martinez-Kaigi V, Nalamada K, Sezgin M, Scheinost D, Hampson M, Louis ED, Constable RT. Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s Disease. Frontiers In Human Neuroscience 2018, 12: 496. PMID: 30581383, PMCID: PMC6292989, DOI: 10.3389/fnhum.2018.00496.Peer-Reviewed Original ResearchCortical-basal ganglia circuitsDorsomedial frontal cortexFunctional connectivityMotor imageryMotivational contextIntentional movementMotor imagery strategyFunctional magnetic resonanceFrontal cortexNeural circuit modelKinesthetic motor imageryParkinson's diseaseLimbic circuitsMotor imagery studiesGanglia circuitsImagery strategyInternal motivationSensory cuesImagery studiesNeurofeedback sessionsSustain movementSensory signalsMotor preparednessCortex circuitBody awarenessAmygdala functional connectivity is associated with social impairments in preterm born young adults
Johns CB, Lacadie C, Vohr B, Ment LR, Scheinost D. Amygdala functional connectivity is associated with social impairments in preterm born young adults. NeuroImage Clinical 2018, 21: 101626. PMID: 30545688, PMCID: PMC6413301, DOI: 10.1016/j.nicl.2018.101626.Peer-Reviewed Original ResearchConceptsVineland Adaptive Behavior ScalesYouth Self-ReportAmygdala functional connectivitySocial impairmentChild Behavior ChecklistFunctional connectivityAmygdala connectivityPreterm participantsSocial functioningSocial functioning correlatesSocial functioning deficitsResting-state functional magnetic resonanceFunctional magnetic resonancePreterm-born adolescentsAdaptive Behavior ScalesAge 16Term-born peersEmotional developmentPreterm birth experienceParent reportDevelopmental trajectoriesRisk of depressionLate adolescentsBehavior ChecklistSelf-Report
2016
Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals
Zakiniaeiz Y, Scheinost D, Seo D, Sinha R, Constable RT. Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals. NeuroImage Clinical 2016, 13: 181-187. PMID: 27981033, PMCID: PMC5144743, DOI: 10.1016/j.nicl.2016.10.019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAUD patientsFunctional connectivityCingulate cortexCox proportional hazards regressionChronic relapsing illnessWhole-brain investigationProportional hazards regressionFunctional connectivity differencesAlcohol-dependent patientsVoxel-wise connectivityNeutral cuesAlcohol-dependent individualsHealthy control participantsFunctional magnetic resonanceRelapse measuresHazards regressionSubsequent relapseDependent patientsInpatient treatmentAlcohol relapseFuture relapsePatientsAlcohol dependenceConnectivity differences
2014
BOLD signal and functional connectivity associated with loving kindness meditation
Garrison KA, Scheinost D, Constable RT, Brewer JA. BOLD signal and functional connectivity associated with loving kindness meditation. Brain And Behavior 2014, 4: 337-347. PMID: 24944863, PMCID: PMC4055184, DOI: 10.1002/brb3.219.Peer-Reviewed Original ResearchConceptsPCC/PCuFunctional connectivityGreater functional connectivityIntrinsic connectivityPosterior cingulate cortex/precuneusParahippocampus/hippocampusSeed-based connectivity analysisBOLD signalBlood oxygen level-dependent (BOLD) signalGroup differencesIntrinsic connectivity distributionLevel-dependent signalKindness meditationCortical midline regionsDefault mode networkFunctional magnetic resonanceInsula lobeInferior frontal gyrusSilent repetitionBrain regionsLeft inferior frontal gyrusFrontal gyrusMidline regionSelf-related processingMode network
2013
Potential Use and Challenges of Functional Connectivity Mapping in Intractable Epilepsy
Constable RT, Scheinost D, Finn ES, Shen X, Hampson M, Winstanley FS, Spencer DD, Papademetris X. Potential Use and Challenges of Functional Connectivity Mapping in Intractable Epilepsy. Frontiers In Neurology 2013, 4: 39. PMID: 23734143, PMCID: PMC3660665, DOI: 10.3389/fneur.2013.00039.Peer-Reviewed Original ResearchFunctional connectivity mappingIntractable epilepsyFunctional connectivityResting-state functional magnetic resonanceConnectivity analysisConnectivity mappingWhole-brain assessmentFunctional brain organizationFunctional connectivity analysisFunctional magnetic resonanceEpileptogenic tissueEpilepsy patientsSurgical proceduresCortical regionsEpilepsyCompensatory responseBrain organizationHuman brainBrainFunctional organizationMagnetic resonanceVoxel levelTissuePatientsReview
2011
Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions
Hampson M, Scheinost D, Qiu M, Bhawnani J, Lacadie CM, Leckman JF, Constable RT, Papademetris X. Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions. Brain Connectivity 2011, 1: 91-98. PMID: 22432958, PMCID: PMC3621512, DOI: 10.1089/brain.2011.0002.Peer-Reviewed Original ResearchConceptsSupplementary motor areaReal-time functional magnetic resonanceFunctional connectivityTourette syndromeFunctional magnetic resonanceMotor areaSubcortical regionsBiofeedback sessionsState functional connectivityTic symptomsMagnetic resonance imaging dataHealthy subjectsTS patientsMagnetic resonanceBrain areasBiofeedbackFunctional magnetic resonance imaging (fMRI) dataFurther studiesSignificant increaseAberrant dynamicsSubjectsRecent studiesImaging dataSessionsPatients