Julie Elizabeth Goodwin MD
Assistant Professor of Pediatrics (Nephrology)
Glucocorticoid-induced hypertension; Vascular endothelial glucocorticoid receptor; Steroids and sepsis; Atherosclerosis; Podocyte glucocorticoid receptor and nephrotic syndrome
- Characterization and mechanism of glucocorticoid-induced hypertension in several mouse models with tissue-specific knockout of the glucocorticoid receptor
Effect of the knockout of the glucocorticoid receptor in the endothelium in a mouse model of LPS-induced sepsis, with and without steroid treatment
Role of the endothelial glucocorticoid receptor in the development of atherosclerosis
Role of the podocyte glucocorticoid receptor in the development of nephrotic syndrome
The glucocorticoid receptor is found in nearly every cell type. It is the receptor for the body's endogenous steroid (cortisol) as well as for the many synthetic steroids (prednisone, dexamethasone) that are used therapeutically for a variety of conditions. Studies have clearly shown that this receptor has tissue-specific functions and that loss of the receptor in specific tissuess produces profound and unexpected phenotypes. I am interested in determining the role of this receptor in the endothelium, and more recently, in podocytes, the specialized cells which maintain the filtration barrier in the kdiney.