Dennis Dee Spencer MD
Harvey and Kate Cushing Professor of Neurosurgery; Chair, Department of Neurosurgery; Director, Epilepsy Surgery Program; Director, Pituitary Tumor Program
Cerebral metabolic abnormalities that sustain epileptogenesis using MR spectroscopy, microdialysis, and human tissue studies
Dr. Spencer's research has brought together basic scientists and clinicians around a program concerning energetics, glutamate metabolism and the neurobiological study of human epileptogenic tissue. Study techniques include 4T MRS, C13 intraoperative glucose turnover studies, and in vivo and in vitro electrophysiology and microdialysis, immunohistochemistry, confocal and EM microscopy, and molecular biology. In particular, laboratory discoveries are correlated with the epileptogenic substrate in order to help define human epilepsy pathogenesis and potential therapies.