Dennis Dee Spencer, MD

Harvey and Kate Cushing Professor of Neurosurgery; Chair, Department of Neurosurgery; Director, Epilepsy Surgery Program; Director, Pituitary Tumor Program

Research Interests

Electrophysiology; Epilepsy; Immunohistochemistry; Microscopy, Electron; Molecular Biology; Neurobiology; Neurosurgery; Magnetic Resonance Spectroscopy; Pituitary Neoplasms; Microdialysis; Microscopy, Confocal

Research Organizations


Research Summary

Dr. Spencer's research has brought together basic scientists and clinicians around a program concerning energetics, glutamate metabolism and the neurobiological study of human epileptogenic tissue. Study techniques include 4T MRS, C13 intraoperative glucose turnover studies, and in vivo and in vitro electrophysiology and microdialysis, immunohistochemistry, confocal and EM microscopy, and molecular biology. In particular, laboratory discoveries are correlated with the epileptogenic substrate in order to help define human epilepsy pathogenesis and potential therapies.

Specialized Terms: Cerebral metabolic abnormalities that sustain epileptogenesis using MR spectroscopy, Microdialysis, and human tissue studies

Selected Publications

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Contact Info

Dennis Dee Spencer, MD
Patient Care Location
Neuroscience CenterYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Mailing Address
NeurosurgeryPO Box 208082
New Haven, CT 06520-8082

Curriculum Vitae