Main Scientific Publications

Xenos D, Kamceva M, Tomasi S, Cardin JA, Schwartz ML, Vaccarino FM: Loss of TrkB Signaling in Parvalbumin-Expressing Basket Cells Results in Network Activity Disruption and Abnormal Behavior. Cereb Cortex. 2017 Aug 18; 2017 Aug 18. PMID: 28968898

Ardhanareeswaran K, Mariani J, Coppola G, Abyzov A, Vaccarino FM: Human induced pluripotent stem cells for modelling neurodevelopmental disorders. Nat Rev Neurol. 2017 May; 2017 Apr 18. PMID: 28418023

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM, Brain Somatic Mosaicism Network.: Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 Apr 28; 2017 Apr 27. PMID: 28450582

Abyzov A, Tomasini L, Zhou B, Vasmatzis N, Coppola G, Amenduni M, Pattni R, Wilson M, Gerstein M, Weissman S, Urban AE, Vaccarino FM: One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin. Genome Res. 2017 Apr; 2017 Feb 24. PMID: 28235832

Salmaso N, Stevens HE, McNeill J, ElSayed M, Ren Q, Maragnoli ME, Schwartz ML, Tomasi S, Sapolsky RM, Duman R, Vaccarino FM: Fibroblast Growth Factor 2 Modulates Hypothalamic Pituitary Axis Activity and Anxiety Behavior Through Glucocorticoid Receptors. Biol Psychiatry. 2016 Sep 15; 2016 Mar 2. PMID: 27133954

Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK: Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7; 2016 Mar 17. PMID: 26997484

Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF, Vaccarino FM: Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biol Psychiatry. 2016 Mar 1; 2014 Jul 24. PMID: 25199956

Frullanti E, Amabile S, Lolli MG, Bartolini A, Livide G, Landucci E, Mari F, Vaccarino FM, Ariani F, Massimino L, Renieri A, Meloni I: Altered expression of neuropeptides in FoxG1-null heterozygous mutant mice. Eur J Hum Genet. 2016 Feb; 2015 May 13. PMID: 25966633

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R: Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 8; 2015 Nov 21. PMID: 26610635

PsychENCODE Consortium., Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N: The PsychENCODE project. Nat Neurosci. 2015 Dec. PMID: 26605881

Salmaso N, Dominguez M, Kravitz J, Komitova M, Vaccarino FM, Schwartz ML: Contribution of maternal oxygenic state to the effects of chronic postnatal hypoxia on mouse body and brain development. Neurosci Lett. 2015 Sep 14; 2015 Jul 26. PMID: 26222256

Leckman JF, Vaccarino FM: Editorial commentary: "What does immunology have to do with brain development and neuropsychiatric disorders?". Brain Res. 2015 Aug 18; 2014 Oct 8. PMID: 25283746

Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM: FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders. Cell. 2015 Jul 16. PMID: 26186191

Stevens HE, Vaccarino FM: How animal models inform child and adolescent psychiatry. J Am Acad Child Adolesc Psychiatry. 2015 May; 2015 Feb 12. PMID: 25901771

Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C: Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561540

Smith KM, Maragnoli ME, Phull PM, Tran KM, Choubey L, Vaccarino FM: Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PLoS One. 2014; 2014 Aug 12. PMID: 25116473

Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL: Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci. 2014 Jul; 2014 Jun 1. PMID: 24880214

Salmaso N, Tomasi S, Vaccarino FM: Neurogenesis and maturation in neonatal brain injury. Clin Perinatol. 2014 Mar; 2013 Dec 15. PMID: 24524457

Salmaso N, Jablonska B, Scafidi J, Vaccarino FM, Gallo V: Neurobiology of premature brain injury. Nat Neurosci. 2014 Mar; 2014 Feb 25. PMID: 24569830

Komitova M, Xenos D, Salmaso N, Tran KM, Brand T, Schwartz ML, Ment L, Vaccarino FM: Hypoxia-induced developmental delays of inhibitory interneurons are reversed by environmental enrichment in the postnatal mouse forebrain. J Neurosci. 2013 Aug 14. PMID: 23946395

Zhang Y, Schulz VP, Reed BD, Wang Z, Pan X, Mariani J, Euskirchen G, Snyder MP, Vaccarino FM, Ivanova N, Weissman SM, Szekely AM: Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration. Proc Natl Acad Sci U S A. 2013 Jul 23; 2013 Jul 8. PMID: 23836664

Rash BG, Tomasi S, Lim HD, Suh CY, Vaccarino FM: Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain. J Neurosci. 2013 Jun 26. PMID: 23804101

Stevens HE, Su T, Yanagawa Y, Vaccarino FM: Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology. 2013 Apr; 2012 Aug 19. PMID: 22910687

Abyzov A, Mariani J, Palejev D, Zhang Y, Haney MS, Tomasini L, Ferrandino AF, Rosenberg Belmaker LA, Szekely A, Wilson M, Kocabas A, Calixto NE, Grigorenko EL, Huttner A, Chawarska K, Weissman S, Urban AE, Gerstein M, Vaccarino FM: Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature. 2012 Dec 20; 2012 Nov 18. PMID: 23160490

Stevens HE, Mariani J, Coppola G, Vaccarino FM: Neurobiology meets genomic science: the promise of human-induced pluripotent stem cells. Dev Psychopathol. 2012 Nov. PMID: 23062309

Mariani J, Simonini MV, Palejev D, Tomasini L, Coppola G, Szekely AM, Horvath TL, Vaccarino FM: Modeling human cortical development in vitro using induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Jul 31; 2012 Jul 3. PMID: 22761314

Salmaso N, Silbereis J, Komitova M, Mitchell P, Chapman K, Ment LR, Schwartz ML, Vaccarino FM: Environmental enrichment increases the GFAP+ stem cell pool and reverses hypoxia-induced cognitive deficits in juvenile mice. J Neurosci. 2012 Jun 27. PMID: 22745493

Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM: Learning and memory depend on fibroblast growth factor receptor 2 functioning in hippocampus. Biol Psychiatry. 2012 Jun 15; 2012 Apr 27. PMID: 22541947

Müller Smith K, Williamson TL, Schwartz ML, Vaccarino FM: Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Res. 2012 Jun 15; 2012 Apr 11. PMID: 22578469

Rash BG, Lim HD, Breunig JJ, Vaccarino FM: FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci. 2011 Oct 26. PMID: 22031906

Bi B, Salmaso N, Komitova M, Simonini MV, Silbereis J, Cheng E, Kim J, Luft S, Ment LR, Horvath TL, Schwartz ML, Vaccarino FM: Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury. J Neurosci. 2011 Jun 22. PMID: 21697371

Vaccarino FM, Stevens HE, Kocabas A, Palejev D, Szekely A, Grigorenko EL, Weissman S: Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders. Neuropharmacology. 2011 Jun; 2011 Mar 1. PMID: 21371482

Vaccarino FM, Urban AE, Stevens HE, Szekely A, Abyzov A, Grigorenko EL, Gerstein M, Weissman S: Annual Research Review: The promise of stem cell research for neuropsychiatric disorders. J Child Psychol Psychiatry. 2011 Apr; 2011 Jan 4. PMID: 21204834

Salmaso N, Vaccarino FM: Toward a novel endogenous anxiolytic factor, fibroblast growth factor 2. Biol Psychiatry. 2011 Mar 15. PMID: 21353835

Stevens HE, Smith KM, Rash BG, Vaccarino FM: Neural stem cell regulation, fibroblast growth factors, and the developmental origins of neuropsychiatric disorders. Front Neurosci. 2010; 2010 Sep 1. PMID: 20877431

Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM: Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci. 2010 Apr 21. PMID: 20410112

Kataoka Y, Kalanithi PS, Grantz H, Schwartz ML, Saper C, Leckman JF, Vaccarino FM: Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. J Comp Neurol. 2010 Feb 1. PMID: 19941350

Komitova M, Vaccarino FM: Exciting news from the adult mouse subventricular zone. Front Neurosci. 2010; 2010 Jan 27. PMID: 20582263

Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML: Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment. Cereb Cortex. 2009 Dec; 2009 Apr 20. PMID: 19380380

Scafidi J, Fagel DM, Ment LR, Vaccarino FM: Modeling premature brain injury and recovery. Int J Dev Neurosci. 2009 Dec; 2009 May 29. PMID: 19482072

Vaccarino FM, Smith KM: Increased brain size in autism--what it will take to solve a mystery. Biol Psychiatry. 2009 Aug 15. PMID: 19643218

Silbereis J, Cheng E, Ganat YM, Ment LR, Vaccarino FM: Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum. Stem Cells. 2009 May. PMID: 19418461

Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE: Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism. J Autism Dev Disord. 2009 Mar; 2008 Oct 13. PMID: 18850329

Fagel DM, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment LR, Vaccarino FM: Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia. J Neurosci. 2009 Jan 28. PMID: 19176828

Chen K, Ohkubo Y, Shin D, Doetschman T, Sanford LP, Li H, Vaccarino FM: Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene. BMC Neurosci. 2008 Sep 30; 2008 Sep 30. PMID: 18826624

Müller Smith K, Fagel DM, Stevens HE, Rabenstein RL, Maragnoli ME, Ohkubo Y, Picciotto MR, Schwartz ML, Vaccarino FM: Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice. Biol Psychiatry. 2008 May 15; 2007 Nov 7. PMID: 17988653

Breunig JJ, Silbereis J, Vaccarino FM, Sestan N, Rakic P: Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A. 2007 Dec 18; 2007 Dec 11. PMID: 18077357

Vaccarino FM, Fagel DM, Ganat Y, Maragnoli ME, Ment LR, Ohkubo Y, Schwartz ML, Silbereis J, Smith KM: Astroglial cells in development, regeneration, and repair. Neuroscientist. 2007 Apr. PMID: 17404377

Ganat YM, Silbereis J, Cave C, Ngu H, Anderson GM, Ohkubo Y, Ment LR, Vaccarino FM: Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo. J Neurosci. 2006 Aug 16. PMID: 16914687

Leckman JF, Vaccarino FM, Kalanithi PS, Rothenberger A: Annotation: Tourette syndrome: a relentless drumbeat--driven by misguided brain oscillations. J Child Psychol Psychiatry. 2006 Jun. PMID: 16712630

Smith KM, Ohkubo Y, Maragnoli ME, Rasin MR, Schwartz ML, Sestan N, Vaccarino FM: Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006 Jun; 2006 May 21. PMID: 16715082

Fagel DM, Ganat Y, Silbereis J, Ebbitt T, Stewart W, Zhang H, Ment LR, Vaccarino FM: Cortical neurogenesis enhanced by chronic perinatal hypoxia. Exp Neurol. 2006 May. PMID: 15916762

Kalanithi PS, Zheng W, Kataoka Y, DiFiglia M, Grantz H, Saper CB, Schwartz ML, Leckman JF, Vaccarino FM: Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proc Natl Acad Sci U S A. 2005 Sep 13; 2005 Aug 30. PMID: 16131542

Ohkubo Y, Uchida AO, Shin D, Partanen J, Vaccarino FM: Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse. J Neurosci. 2004 Jul 7. PMID: 15240797

Vaccarino FM, Ment LR: Injury and repair in developing brain. Arch Dis Child Fetal Neonatal Ed. 2004 May. PMID: 15102716

Zheng W, Nowakowski RS, Vaccarino FM: Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Dev Neurosci. 2004 Mar-Aug. PMID: 15711059

Vaccarino FM, Ganat Y, Zhang Y, Zheng W: Stem cells in neurodevelopment and plasticity. Neuropsychopharmacology. 2001 Dec. PMID: 11750175

Raballo R, Rhee J, Lyn-Cook R, Leckman JF, Schwartz ML, Vaccarino FM: Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J Neurosci. 2000 Jul 1. PMID: 10864959

Baas D, Bumsted KM, Martinez JA, Vaccarino FM, Wikler KC, Barnstable CJ: The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res Mol Brain Res. 2000 May 31. PMID: 10891582

Acampora D, Postiglione MP, Avantaggiato V, Di Bonito M, Vaccarino FM, Michaud J, Simeone A: Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. Genes Dev. 1999 Nov 1. PMID: 10557207

Vaccarino FM, Schwartz ML, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin JD, Wyland JJ, Hung YT: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis Nat Neurosci. 1999 Sep. PMID: 10461229

Lin X, State MW, Vaccarino FM, Greally J, Hass M, Leckman JF: Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). Genomics. 1999 Aug 15. PMID: 10458915

Vaccarino FM, Schwartz ML, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin JD, Wyland JJ, Hung YT: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci. 1999 Mar. PMID: 10195217

Vaccarino FM, Schwartz ML, Raballo R, Rhee J, Lyn-Cook R: Fibroblast growth factor signaling regulates growth and morphogenesis at multiple steps during brain development. Curr Top Dev Biol. 1999. PMID: 10417880

Ding M, Robel L, James AJ, Eisenstat DD, Leckman JF, Rubenstein JL, Vaccarino FM: Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia. J Mol Neurosci. 1997 Apr. PMID: 9188040

Lin X, Swaroop A, Vaccarino FM, Murtha MT, Haas M, Ji X, Ruddle FH, Leckman JF: Characterization and sequence analysis of the human homeobox-containing gene GBX2. Genomics. 1996 Feb 1. PMID: 8838315

Robel L, Ding M, James AJ, Lin X, Simeone A, Leckman JF, Vaccarino FM: Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon. J Neurosci. 1995 Dec. PMID: 8613727

Vaccarino FM, Schwartz ML, Hartigan D, Leckman JF: Basic fibroblast growth factor increases the number of excitatory neurons containing glutamate in the cerebral cortex. Cereb Cortex. 1995 Jan-Feb. PMID: 7719131

Gallo V, Patneau DK, Mayer ML, Vaccarino FM: Excitatory amino acid receptors in glial progenitor cells: molecular and functional properties. Glia. 1994 Jun. PMID: 7927651

Vaccarino FM, Hayward MD, Le HN, Hartigan DJ, Duman RS, Nestler EJ: Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Brain Res Mol Brain Res. 1993 Jul. PMID: 8103187

Vaccarino FM, Hayward MD, Nestler EJ, Duman RS, Tallman JF: Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Brain Res Mol Brain Res. 1992 Jan. PMID: 1347632

Eva C, Bovolin P, Balzac F, Botta C, Gamalero SR, Vaccarino FM: Primary cultures of corticostriatal cells from newborn rats: a model to study muscarinic receptor subtypes regulation and function. J Mol Neurosci. 1990. PMID: 2177349

Vaccarino FM: Glutamate receptors, protein kinase C translocation, and gangliosides. Psychopharmacol Bull. 1988. PMID: 2856417

Vaccarino FM, Alho H, Santi MR, Guidotti A: Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells. J Neurosci. 1987 Jan. PMID: 3027277

Vicini S, Alho H, Costa E, Mienville JM, Santi MR, Vaccarino FM: Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures. Proc Natl Acad Sci U S A. 1986 Dec. PMID: 3097650

Vaccarino FM, Ghetti B, Wade SE, Rea MA, Aprison MH: Loss of Purkinje cell-associated benzodiazepine receptors spares a high affinity subpopulation: a study with pcd mutant mice. J Neurosci Res. 1983. PMID: 6304330