Current Lab Members
Congenital Abnormalities; Cerebral Cortex; Neurobiology; Prenatal Diagnosis; Mental Disorders Diagnosed in Childhood
My research is focused on transcriptional and regulatory programs that precisely orchestrate the formation of the neocortex. Disruption of these mechanisms cause neurological and psychological disorders. I apply a systems biology approach in combination with molecular genetics to decipher both conserved and species-specific developmental mechanisms.
Central Nervous System; Neurodegenerative Diseases
Many years of experience in worldwide laboratories (Russia, France, Norway and Hungary) lend to expertise in the methods of scanning and transmission electron microscopy including pre- and post-embedding immunolabeling. This also let me introduce to Yale the method of three-dimensional reconstruction of large cell fragments such as neuron cell bodies or processes from serial electron micrographs.
Anatomy; Brain; Cell Biology; Embryology; Disorders of Environmental Origin; Nervous System Malformations; Neurosciences; Stem Cells; Embryo Research; Fetal Research; Genetic Research; Neurogenesis; Optogenetics; Chemicals and Drugs
My research focuses on the molecular and cellular basis of early cerebral cortex development. I study how cortical stem cells, known as radial glial cells, proliferate and differentiate into post-mitotic neurons. With modern optogenetic methods, we are uncovering key cellular dynamics of cortical stem cells during neurogenesis which are important for brain growth and gyrification—the process of cortex folding during development (see Rash BG et al., 2016, Sci. Adv., and Rash BG et al., 2013, J....
Summary of Research and Future Directions: My interest is in how neurons change their connectivity and structure during the "critical period" of development and how this may be applicable to human disorders. Currently, I am investigating the possibility of inducing critical period-like synaptic plasticity in an adult
I am interested in developmental dynamics, i.e. changes to the neural stem cell niche as development proceeds through time. I am interested in neural molecular identity, differentiation, and cell fate restriction in early cortical progenitors. My thesis work focuses on the interactions between both novel and well-established transcriptional regulators in cortex development.