Exploring How a Cell Consumes Itself
- Theodore Agbi and Yonas Takele were each awarded a STARS summer fellowship and will join the lab this summer. Welcome Theo and Yonas!
How autophagy proteins determine the unique structure of the autophagosome is just beginning to be understood. Our first efforts to study how the strident curvature present at the expanding rim of the growing phagophore might influence local biochemistry have just been published:
- Nath et al. 2014. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane curvature-sensing domain in Atg3. Nature Cell Biology , 16, 415-424.
- Dancourt and Melia, 2014. Lipidation of the autophagy proteins LC3 and GABARAP is a membrane-curvature dependent process. Autophagy, in press.