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Probing fundamental mechanisms of nuclear compartmentalization

A synthetic nuclear pore complex. Courtesy of Chenxiang Lin.

The overall goal of the Lusk lab is to answer problems fundamental to understanding cellular function as a means to inform molecular mechanisms that impact human health. At the center of this pursuit is the investigation of the essential molecular mechanisms that control the organization, structure and function of the nuclear envelope: the membrane system that encapsulates the genome of all eukaryotes.

Disruption of the function of the nuclear envelope has profound effects on cellular processes due to impaired nuclear compartmentalization, altered gene expression, and loss of genome stability. Consistent with this, dozens of human diseases that range from cancers to neurodegeneration to premature aging are associated with nuclear envelope malfunction.  Our lab, in collaboration with colleagues, employs a multidisciplinary approach to illuminate the fundamental mechanisms that contribute to nuclear envelope integrity, nuclear compartmentalization and 3D-genome organization.

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