Fragile X Syndrome

Fragile X syndrome is a developmental disorder that is one of the translational neuroscience projects in the lab. Dr. Susan Goebel-Goody is in charge of this project and is currently writing up her results. The basic hypothesis being tested is that STEP is over-expressed in this disorder. This in turn leads to a disruption of synaptic plasticity and contributes to the cognitive deficits that are present. Here are two review columns on fragile x syndrome written by Marilee Ogren, Ph.D. and myself.

Review Columns


Reversing the effects of fragile X syndrome.

Ogren MP, Lombroso PJ.

J Am Acad Child Adolesc Psychiatry. 2008 Aug;47 (8) :863-7. PMID: 18645420


Fragile X syndrome: keys to the molecular genetics of synaptic plasticity.

Lombroso PJ, Ogren MP.

J Am Acad Child Adolesc Psychiatry. 2008 Jul;47 (7) :736-9. PMID: 18574398