Fragile X syndrome is a developmental disorder that is one of the translational neuroscience projects in the lab. Dr. Susan Goebel-Goody is in charge of this project and is currently writing up her results. The basic hypothesis being tested is that STEP is over-expressed in this disorder. This in turn leads to a disruption of synaptic plasticity and contributes to the cognitive deficits that are present. Here are two review columns on fragile x syndrome written by Marilee Ogren, Ph.D. and myself.
- Ogren MP, Lombroso PJ: Reversing the effects of fragile X syndrome. J Am Acad Child Adolesc Psychiatry. 2008 Aug. PMID: 18645420
- Lombroso PJ, Ogren MP: Fragile X syndrome: keys to the molecular genetics of synaptic plasticity. J Am Acad Child Adolesc Psychiatry. 2008 Jul. PMID: 18574398