Select Publications

Itch

1.

Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity.

Fu K, Qu L, Shimada SG, Nie H, LaMotte RH.

Neurosci Lett. 2014 Sep 5;579 :190-4. Epub 2014 Apr 3. PMID: 24704378

2.

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.

Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH.

Brain. 2014 Apr;137 (Pt 4) :1039-50. Epub 2014 Feb 18. PMID: 24549959

3.

Sensory neurons and circuits mediating itch.

LaMotte RH, Dong X, Ringkamp M.

Nat Rev Neurosci. 2014 Jan;15 (1) :19-31. PMID: 24356071

4.

A subpopulation of nociceptors specifically linked to itch.

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X.

Nat Neurosci. 2013 Feb;16 (2) :174-82. Epub 2012 Dec 23. PMID: 23263443

5.

Mechanisms of itch evoked by β-alanine.

Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X.

J Neurosci. 2012 Oct 17;32 (42) :14532-7. PMID: 23077038

6.

In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans.

Ma C, Nie H, Gu Q, Sikand P, Lamotte RH.

J Neurophysiol. 2012 Jan;107 (1) :357-63. Epub 2011 Oct 12. PMID: 21994268

7.

Sensory responses to injection and punctate application of capsaicin and histamine to the skin.

Sikand P, Shimada SG, Green BG, LaMotte RH.

Pain. 2011 Nov;152 (11) :2485-94. Epub 2011 Jul 29. PMID: 21802851

8.

A role for nociceptive, myelinated nerve fibers in itch sensation.

Ringkamp M, Schepers RJ, Shimada SG, Johanek LM, Hartke TV, Borzan J, Shim B, LaMotte RH, Meyer RA.

J Neurosci. 2011 Oct 19;31 (42) :14841-9. PMID: 22016517

9.

Mouse models of acute, chemical itch and pain in humans.

LaMotte RH, Shimada SG, Sikand P.

Exp Dermatol. 2011 Oct;20 (10) :778-82. PMID: 21929688

10.

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.

Sikand P, Dong X, LaMotte RH.

J Neurosci. 2011 May 18;31 (20) :7563-7. PMID: 21593341

11.

Cathepsin S elicits itch and signals via protease-activated receptors.

Reddy VB, Shimada SG, Sikand P, Lamotte RH, Lerner EA.

J Invest Dermatol. 2010 May;130 (5) :1468-70. Epub 2010 Jan 14. PMID: 20072136

12.

Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.

Sikand P, Shimada SG, Green BG, LaMotte RH.

Pain. 2009 Jul;144 (1-2) :66-75. Epub 2009 May 6. PMID: 19423224

13.

Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.

LaMotte RH, Shimada SG, Green BG, Zelterman D.

J Neurophysiol. 2009 Mar;101 (3) :1430-43. Epub 2009 Jan 14. PMID: 19144738

14.

Behavioral differentiation between itch and pain in mouse.

Shimada SG, LaMotte RH.

Pain. 2008 Oct 31;139 (3) :681-7. Epub 2008 Sep 11. PMID: 18789837

15.

A role for polymodal C-fiber afferents in nonhistaminergic itch.

Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, Hartke T, LaMotte RH, Ringkamp M.

J Neurosci. 2008 Jul 23;28 (30) :7659-69. PMID: 18650342

16.

Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.

Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA.

J Neurosci. 2008 Apr 23;28 (17) :4331-5. PMID: 18434511

17.

Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.

Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, Ringkamp M.

J Neurosci. 2007 Jul 11;27 (28) :7490-7. PMID: 17626210

18.

Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.

Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr.

J Neurophysiol. 2004 Jan;91 (1) :213-22. PMID: 14715718

19.

Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.

Brull SJ, Atanassoff PG, Silverman DG, Zhang J, Lamotte RH.

Somatosens Mot Res. 1999;16 (4) :299-303. PMID: 10632027

20.

Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.

Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, Lamotte RH.

Somatosens Mot Res. 1999;16 (4) :291-8. PMID: 10632026

21.

Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine.

Simone DA, Alreja M, LaMotte RH.

Somatosens Mot Res. 1991;8 (3) :271-9. PMID: 1767623

23.

The magnitude and duration of itch produced by intracutaneous injections of histamine.

Simone DA, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH.

Somatosens Res. 1987;5 (2) :81-92. PMID: 3423533

Pain

1.

Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity.

Fu K, Qu L, Shimada SG, Nie H, LaMotte RH.

Neurosci Lett. 2014 Sep 5;579 :190-4. Epub 2014 Apr 3. PMID: 24704378

2.

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.

Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH.

Brain. 2014 Apr;137 (Pt 4) :1039-50. Epub 2014 Feb 18. PMID: 24549959

3.

Sensory neurons and circuits mediating itch.

LaMotte RH, Dong X, Ringkamp M.

Nat Rev Neurosci. 2014 Jan;15 (1) :19-31. PMID: 24356071

4.

A subpopulation of nociceptors specifically linked to itch.

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X.

Nat Neurosci. 2013 Feb;16 (2) :174-82. Epub 2012 Dec 23. PMID: 23263443

5.

Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons.

Qu L, Li Y, Pan X, Zhang P, LaMotte RH, Ma C.

J Neurosci. 2012 Jul 11;32 (28) :9554-62. PMID: 22787041

6.

In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans.

Ma C, Nie H, Gu Q, Sikand P, Lamotte RH.

J Neurophysiol. 2012 Jan;107 (1) :357-63. Epub 2011 Oct 12. PMID: 21994268

7.

Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons.

Fan N, Donnelly DF, LaMotte RH.

J Neurophysiol. 2011 Dec;106 (6) :3067-72. Epub 2011 Sep 14. PMID: 21917996

8.

Sensory responses to injection and punctate application of capsaicin and histamine to the skin.

Sikand P, Shimada SG, Green BG, LaMotte RH.

Pain. 2011 Nov;152 (11) :2485-94. Epub 2011 Jul 29. PMID: 21802851

9.

A role for nociceptive, myelinated nerve fibers in itch sensation.

Ringkamp M, Schepers RJ, Shimada SG, Johanek LM, Hartke TV, Borzan J, Shim B, LaMotte RH, Meyer RA.

J Neurosci. 2011 Oct 19;31 (42) :14841-9. PMID: 22016517

10.

Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons.

Qu L, Zhang P, LaMotte RH, Ma C.

Brain Behav Immun. 2011 Oct;25 (7) :1399-407. Epub 2011 Apr 18. PMID: 21521651

11.

Mouse models of acute, chemical itch and pain in humans.

LaMotte RH, Shimada SG, Sikand P.

Exp Dermatol. 2011 Oct;20 (10) :778-82. PMID: 21929688

12.

Increased Na+ and K+ currents in small mouse dorsal root ganglion neurons after ganglion compression.

Fan N, Sikand P, Donnelly DF, Ma C, Lamotte RH.

J Neurophysiol. 2011 Jul;106 (1) :211-8. Epub 2011 Apr 27. PMID: 21525373

13.

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.

Sikand P, Dong X, LaMotte RH.

J Neurosci. 2011 May 18;31 (20) :7563-7. PMID: 21593341

15.

Altered functional properties of satellite glial cells in compressed spinal ganglia.

Zhang H, Mei X, Zhang P, Ma C, White FA, Donnelly DF, Lamotte RH.

Glia. 2009 Nov 15;57 (15) :1588-99. PMID: 19330845

16.

Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.

Sikand P, Shimada SG, Green BG, LaMotte RH.

Pain. 2009 Jul;144 (1-2) :66-75. Epub 2009 May 6. PMID: 19423224

17.

Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.

LaMotte RH, Shimada SG, Green BG, Zelterman D.

J Neurophysiol. 2009 Mar;101 (3) :1430-43. Epub 2009 Jan 14. PMID: 19144738

18.

Functional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion.

Xiang Z, Xiong Y, Yan N, Li X, Mao Y, Ni X, He C, LaMotte RH, Burnstock G, Sun J.

Pain. 2008 Nov 15;140 (1) :23-34. Epub 2008 Aug 19. PMID: 18715715

19.

Behavioral differentiation between itch and pain in mouse.

Shimada SG, LaMotte RH.

Pain. 2008 Oct 31;139 (3) :681-7. Epub 2008 Sep 11. PMID: 18789837

20.

Hyperexcitable neurons and altered non-neuronal cells in the compressed spinal ganglion.

LaMotte RH, Ma C.

Sheng Li Xue Bao. 2008 Oct 25;60 (5) :597-602. PMID: 18958366

21.

A role for polymodal C-fiber afferents in nonhistaminergic itch.

Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, Hartke T, LaMotte RH, Ringkamp M.

J Neurosci. 2008 Jul 23;28 (30) :7659-69. PMID: 18650342

24.

MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia.

Sun JH, Yang B, Donnelly DF, Ma C, LaMotte RH.

J Neurophysiol. 2006 Nov;96 (5) :2189-99. Epub 2006 Jun 14. PMID: 16775210

25.

Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons.

Ma C, Greenquist KW, Lamotte RH.

J Neurophysiol. 2006 Apr;95 (4) :2098-107. Epub 2005 Dec 28. PMID: 16381809

26.

Effects of a chronic compression of the dorsal root ganglion on voltage-gated Na+ and K+ currents in cutaneous afferent neurons.

Tan ZY, Donnelly DF, LaMotte RH.

J Neurophysiol. 2006 Feb;95 (2) :1115-23. PMID: 16424456

27.

Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion.

White FA, Sun J, Waters SM, Ma C, Ren D, Ripsch M, Steflik J, Cortright DN, Lamotte RH, Miller RJ.

Proc Natl Acad Sci U S A. 2005 Sep 27;102 (39) :14092-7. Epub 2005 Sep 20. PMID: 16174730

29.

Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.

Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr.

J Neurophysiol. 2004 Jan;91 (1) :213-22. PMID: 14715718

30.

Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators.

Song XJ, Zhang JM, Hu SJ, LaMotte RH.

Pain. 2003 Aug;104 (3) :701-9. PMID: 12927643

31.

Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons.

Ma C, Shu Y, Zheng Z, Chen Y, Yao H, Greenquist KW, White FA, LaMotte RH.

J Neurophysiol. 2003 Mar;89 (3) :1588-602. Epub 2002 Nov 20. PMID: 12612024

32.

Protein kinase A modulates spontaneous activity in chronically compressed dorsal root ganglion neurons in the rat.

Hu SJ, Song XJ, Greenquist KW, Zhang JM, LaMotte RH.

Pain. 2001 Oct;94 (1) :39-46. PMID: 11576743

34.

Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia.

Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH.

J Neurophysiol. 1999 Dec;82 (6) :3347-58. PMID: 10601466

35.

Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.

Brull SJ, Atanassoff PG, Silverman DG, Zhang J, Lamotte RH.

Somatosens Mot Res. 1999;16 (4) :299-303. PMID: 10632027

36.

Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.

Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, Lamotte RH.

Somatosens Mot Res. 1999;16 (4) :291-8. PMID: 10632026

37.

Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons.

Zhang JM, Donnelly DF, Song XJ, Lamotte RH.

J Neurophysiol. 1997 Nov;78 (5) :2790-4. PMID: 9356426

41.

Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat.

Xie Y, Zhang J, Petersen M, LaMotte RH.

J Neurophysiol. 1995 May;73 (5) :1811-20. PMID: 7623082

42.

Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells.

Petersen M, LaMotte RH.

Pain. 1993 Jul;54 (1) :37-42. PMID: 7690929

43.

Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans.

Torebjörk HE, Lundberg LE, LaMotte RH.

J Physiol. 1992 Mar;448 :765-80. PMID: 1593489

44.

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

LaMotte RH, Lundberg LE, Torebjörk HE.

J Physiol. 1992 Mar;448 :749-64. PMID: 1593488

45.

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.

Simone DA, Sorkin LS, Oh U, Chung JM, Owens C, LaMotte RH, Willis WD.

J Neurophysiol. 1991 Jul;66 (1) :228-46. PMID: 1919669

46.

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.

Baumann TK, Simone DA, Shain CN, LaMotte RH.

J Neurophysiol. 1991 Jul;66 (1) :212-27. PMID: 1919668

47.

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms.

LaMotte RH, Shain CN, Simone DA, Tsai EF.

J Neurophysiol. 1991 Jul;66 (1) :190-211. PMID: 1919666

48.

Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine.

Simone DA, Alreja M, LaMotte RH.

Somatosens Mot Res. 1991;8 (3) :271-9. PMID: 1767623

49.

A model of peripheral mononeuropathy in the rat.

Hirata H, Pataky A, Kajander K, LaMotte RH, Collins JG.

Pain. 1990 Aug;42 (2) :253-5. PMID: 2174143

50.

Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin.

Simone DA, Baumann TK, LaMotte RH.

Pain. 1989 Jul;38 (1) :99-107. PMID: 2780068

52.

Hyperalgesia to heat after intradermal injection of capsaicin.

Simone DA, Ngeow JY, Putterman GJ, LaMotte RH.

Brain Res. 1987 Aug 18;418 (1) :201-3. PMID: 3664271

53.

The magnitude and duration of itch produced by intracutaneous injections of histamine.

Simone DA, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH.

Somatosens Res. 1987;5 (2) :81-92. PMID: 3423533

54.

James Daniel Hardy (1904-1985). Tribute to a pioneer in pain psychophysics.

LaMotte RH.

Pain. 1986 Oct;27 (1) :127-30. PMID: 3537920

55.

Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human.

LaMotte RH, Torebjörk HE, Robinson CJ, Thalhammer JG.

J Neurophysiol. 1984 Jun;51 (6) :1434-50. PMID: 6737035

57.

Can the sensitization of nociceptors account for hyperalgesia after skin injury?

LaMotte RH.

Hum Neurobiol. 1984;3 (1) :47-52. PMID: 6330011

58.

Psychophysical detection and pain ratings of incremental thermal stimuli: a comparison with nociceptor responses in humans.

Robinson CJ, Torebjörk HE, LaMotte RH.

Brain Res. 1983 Sep 5;274 (1) :87-106. PMID: 6616259

60.

Information processing in cutaneous nociceptors in relation to sensations of pain.

LaMotte RH.

Fed Proc. 1983 Jun;42 (9) :2548-52. PMID: 6852273

61.

Latency to detection of first pain.

Campbell JN, LaMotte RH.

Brain Res. 1983 May 5;266 (2) :203-8. PMID: 6871657

62.

Response properties of high-threshold cutaneous cold receptors in the primate.

LaMotte RH, Thalhammer JG.

Brain Res. 1982 Jul 29;244 (2) :279-87. PMID: 7116176

63.

Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat.

LaMotte RH, Thalhammer JG, Torebjörk HE, Robinson CJ.

J Neurosci. 1982 Jun;2 (6) :765-81. PMID: 7086482

Touch

1.

Magnitude estimation of softness.

Friedman RM, Hester KD, Green BG, LaMotte RH.

Exp Brain Res. 2008 Nov;191 (2) :133-42. Epub 2008 Aug 5. PMID: 18679665

2.

Neural coding of the location and direction of a moving object by a spatially distributed population of mechanoreceptors.

Friedman RM, Khalsa PS, Greenquist KW, LaMotte RH.

J Neurosci. 2002 Nov 1;22 (21) :9556-66. PMID: 12417680

3.

Softness discrimination with a tool.

LaMotte RH.

J Neurophysiol. 2000 Apr;83 (4) :1777-86. PMID: 10758090

4.

Raised object on a planar surface stroked across the fingerpad: responses of cutaneous mechanoreceptors to shape and orientation.

LaMotte RH, Friedman RM, Lu C, Khalsa PS, Srinivasan MA.

J Neurophysiol. 1998 Nov;80 (5) :2446-66. PMID: 9819255

5.

Neural encoding of shape: responses of cutaneous mechanoreceptors to a wavy surface stroked across the monkey fingerpad.

LaMotte RH, Srinivasan MA.

J Neurophysiol. 1996 Dec;76 (6) :3787-97. PMID: 8985876

6.

Tactual discrimination of softness.

Srinivasan MA, LaMotte RH.

J Neurophysiol. 1995 Jan;73 (1) :88-101. PMID: 7714593

7.

Cutaneous neural codes for shape.

LaMotte RH, Srinivasan MA, Lu C, Klusch-Petersen A.

Can J Physiol Pharmacol. 1994 May;72 (5) :498-505. PMID: 7954079

9.

Tactile detection of slip: surface microgeometry and peripheral neural codes.

Srinivasan MA, Whitehouse JM, LaMotte RH.

J Neurophysiol. 1990 Jun;63 (6) :1323-32. PMID: 2358880

13.

Tactile detection of a dot on a smooth surface: peripheral neural events.

LaMotte RH, Whitehouse J.

J Neurophysiol. 1986 Oct;56 (4) :1109-28. PMID: 3097273

14.

Psychophysical detection and pain ratings of incremental thermal stimuli: a comparison with nociceptor responses in humans.

Robinson CJ, Torebjörk HE, LaMotte RH.

Brain Res. 1983 Sep 5;274 (1) :87-106. PMID: 6616259

15.

Tactile detection thresholds for a single asperity on an otherwise smooth surface.

Johansson RS, LaMotte RH.

Somatosens Res. 1983;1 (1) :21-31. PMID: 6679912