Select Publications



Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity.

Fu K, Qu L, Shimada SG, Nie H, LaMotte RH.

Neurosci Lett. 2014 Sep 5;579 :190-4. Epub 2014 Apr 3. PMID: 24704378


Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.

Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH.

Brain. 2014 Apr;137 (Pt 4) :1039-50. Epub 2014 Feb 18. PMID: 24549959


Sensory neurons and circuits mediating itch.

LaMotte RH, Dong X, Ringkamp M.

Nat Rev Neurosci. 2014 Jan;15 (1) :19-31. PMID: 24356071


A subpopulation of nociceptors specifically linked to itch.

Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X.

Nat Neurosci. 2013 Feb;16 (2) :174-82. Epub 2012 Dec 23. PMID: 23263443


Mechanisms of itch evoked by β-alanine.

Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X.

J Neurosci. 2012 Oct 17;32 (42) :14532-7. PMID: 23077038


In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans.

Ma C, Nie H, Gu Q, Sikand P, Lamotte RH.

J Neurophysiol. 2012 Jan;107 (1) :357-63. Epub 2011 Oct 12. PMID: 21994268


Sensory responses to injection and punctate application of capsaicin and histamine to the skin.

Sikand P, Shimada SG, Green BG, LaMotte RH.

Pain. 2011 Nov;152 (11) :2485-94. Epub 2011 Jul 29. PMID: 21802851


A role for nociceptive, myelinated nerve fibers in itch sensation.

Ringkamp M, Schepers RJ, Shimada SG, Johanek LM, Hartke TV, Borzan J, Shim B, LaMotte RH, Meyer RA.

J Neurosci. 2011 Oct 19;31 (42) :14841-9. PMID: 22016517


Mouse models of acute, chemical itch and pain in humans.

LaMotte RH, Shimada SG, Sikand P.

Exp Dermatol. 2011 Oct;20 (10) :778-82. PMID: 21929688


BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.

Sikand P, Dong X, LaMotte RH.

J Neurosci. 2011 May 18;31 (20) :7563-7. PMID: 21593341


Cathepsin S elicits itch and signals via protease-activated receptors.

Reddy VB, Shimada SG, Sikand P, Lamotte RH, Lerner EA.

J Invest Dermatol. 2010 May;130 (5) :1468-70. Epub 2010 Jan 14. PMID: 20072136


Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.

Sikand P, Shimada SG, Green BG, LaMotte RH.

Pain. 2009 Jul;144 (1-2) :66-75. Epub 2009 May 6. PMID: 19423224


Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.

LaMotte RH, Shimada SG, Green BG, Zelterman D.

J Neurophysiol. 2009 Mar;101 (3) :1430-43. Epub 2009 Jan 14. PMID: 19144738


Behavioral differentiation between itch and pain in mouse.

Shimada SG, LaMotte RH.

Pain. 2008 Oct 31;139 (3) :681-7. Epub 2008 Sep 11. PMID: 18789837


A role for polymodal C-fiber afferents in nonhistaminergic itch.

Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, Hartke T, LaMotte RH, Ringkamp M.

J Neurosci. 2008 Jul 23;28 (30) :7659-69. PMID: 18650342


Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.

Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA.

J Neurosci. 2008 Apr 23;28 (17) :4331-5. PMID: 18434511


Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.

Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, Ringkamp M.

J Neurosci. 2007 Jul 11;27 (28) :7490-7. PMID: 17626210


Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.

Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr.

J Neurophysiol. 2004 Jan;91 (1) :213-22. PMID: 14715718


Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.

Brull SJ, Atanassoff PG, Silverman DG, Zhang J, Lamotte RH.

Somatosens Mot Res. 1999;16 (4) :299-303. PMID: 10632027


Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.

Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, Lamotte RH.

Somatosens Mot Res. 1999;16 (4) :291-8. PMID: 10632026


Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine.

Simone DA, Alreja M, LaMotte RH.

Somatosens Mot Res. 1991;8 (3) :271-9. PMID: 1767623


The magnitude and duration of itch produced by intracutaneous injections of histamine.

Simone DA, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH.

Somatosens Res. 1987;5 (2) :81-92. PMID: 3423533