Role of TSP-2

My laboratory is also focused on elucidating the mechanism through which the endogeno us inhibitor of angiogenesis TSP-2 limits angiogenesis and art eriogene sis.

Molecular Events in the Foreign Body Response

When biomaterial and medical devices are surgically implanted into the body, a series of molecular and cellular events lead to its encapsulation and isolation from surrounding tissue. This series of events is known as the Foreign Body Reaction ( FBR) and can limit the device's overall biocompatibility and function. Every foreign surface first acquires a protein coat when within the body, composed of fibrinogen, albumin, fibronectin and other blood and interstitial-fluid proteins.