Publications

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC and Kyriakides TR: Upregulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair due to Abnormalities in Fibroblast Function. J Biol Chem. 2014 Nov 11; Epub 2014 Nov 11. PMID: 25389299


Moore LB, Sawyer AJ, Charokopos A, Skokos EA and Kyriakides TR: Loss of monocyte chemoattractant protein-1 alters macrophage polarization and reduces NFκB activation in the foreign body response. Acta Biomater. 2014 Sep 19; Epub 2014 Sep 19. PMID: 25242651


Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M and Sessa WC: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A. 2014 Sep 2;111 (35) :12865-70. Epub 2014 Aug 18. PMID: 25136137


Calabro NE, Kristofik NJ and Kyriakides TR: Thrombospondin-2 and extracellular matrix assembly. Biochim Biophys Acta. 2014 Aug;1840 (8) :2396-402. Epub 2014 Jan 15. PMID: 24440155


Sawyer AJ, Tian W, Saucier-Sawyer JK, Rizk PJ, Saltzman WM, Bellamkonda RV and Kyriakides TR: The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. Biomaterials. 2014 Aug;35 (25) :6698-706. Epub 2014 May 29. PMID: 24881026


Morris AH and Kyriakides TR: Matricellular proteins and biomaterials. Matrix Biol. 2014 Jul;37 :183-91. Epub 2014 Mar 20. PMID: 24657843


Padmanabhan J, Kinser ER, Stalter MA, Duncan-Lewis C, Balestrini JL, Sawyer AJ, Schroers J and Kyriakides TR: Engineering cellular response using nanopatterned bulk metallic glass. ACS Nano. 2014 May 27;8 (5) :4366-75. Epub 2014 Apr 17. PMID: 24724817

Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S and Kyriakides TR: A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharm. 2013 Sep 10;453 (2) :651-5. Epub 2013 May 29. PMID: 23727592


Kobsa S, Kristofik NJ, Sawyer AJ, Bothwell AL, Kyriakides TR and Saltzman WM: An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds. Biomaterials. 2013 May;34 (15) :3891-901. Epub 2013 Feb 27. PMID: 23453058


Sawyer AJ and Kyriakides TR: Nanoparticle-based evaluation of blood-brain barrier leakage during the foreign body response. J Neural Eng. 2013 Feb;10 (1) :016013. Epub 2013 Jan 21. PMID: 23337399

Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR and Mehal WZ: Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci U S A. 2011 Dec 13;108 (50) :20095-100. Epub 2011 Nov 22. PMID: 22109549


MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC and Kyriakides TR: Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2. Proc Natl Acad Sci U S A. 2011 Nov 15;108 (46) :E1137-45. Epub 2011 Sep 26. PMID: 21949402


Liu J, Jiang Z, Zhang S, Liu C, Gross RA, Kyriakides TR and Saltzman WM: Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters. Biomaterials. 2011 Sep;32 (27) :6646-54. PMID: 21641030


Tian W, Sawyer A, Kocaoglu FB and Kyriakides TR: Astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier. Am J Pathol. 2011 Aug;179 (2) :860-8. Epub 2011 Jun 23. PMID: 21704005


Skokos EA, Charokopos A, Khan K, Wanjala J and Kyriakides TR: Lack of TNF-α-induced MMP-9 production and abnormal E-cadherin redistribution associated with compromised fusion in MCP-1-null macrophages. Am J Pathol. 2011 May;178 (5) :2311-21. PMID: 21514443

Zhou J, Tang PC, Qin L, Gayed PM, Li W, Skokos EA, Kyriakides TR, Pober JS and Tellides G: CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. J Exp Med. 2010 Aug 30;207 (9) :1951-66. Epub 2010 Aug 23. PMID: 20733031


Jay SM, Shepherd BR, Andrejecsk JW, Kyriakides TR, Pober JS and Saltzman WM: Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials. 2010 Apr;31 (11) :3054-62. Epub 2010 Jan 27. PMID: 20110124


Jay SM, Skokos EA, Zeng J, Knox K and Kyriakides TR: Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models. J Biomed Mater Res A. 2010 Apr;93 (1) :189-99. PMID: 19536825


Roh JD, Sawh-Martinez R, Brennan MP, Jay SM, Devine L, Rao DA, Yi T, Mirensky TL, Nalbandian A, Udelsman B, Hibino N, Shinoka T, Saltzman WM, Snyder E, Kyriakides TR, Pober JS and Breuer CK: Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proc Natl Acad Sci U S A. 2010 Mar 9;107 (10) :4669-74. Epub 2010 Mar 5. PMID: 20207947

Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR and Sessa WC: Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A. 2009 Oct 13;106 (41) :17511-6. Epub 2009 Sep 25. PMID: 19805174


Maclauchlan S, Skokos EA, Agah A, Zeng J, Tian W, Davidson JM, Bornstein P and Kyriakides TR: Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF. J Histochem Cytochem. 2009 Apr;57 (4) :301-13. Epub 2008 Nov 24. PMID: 19029404


MacLauchlan S, Skokos EA, Meznarich N, Zhu DH, Raoof S, Shipley JM, Senior RM, Bornstein P and Kyriakides TR: Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9. J Leukoc Biol. 2009 Apr;85 (4) :617-26. Epub 2009 Jan 13. PMID: 19141565


Tian W and Kyriakides TR: Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1beta levels and leakage of the blood-brain barrier. Matrix Biol. 2009 Apr;28 (3) :148-59. Epub 2009 Mar 3. PMID: 19264129


Kyriakides TR, Wulsin D, Skokos EA, Fleckman P, Pirrone A, Shipley JM, Senior RM and Bornstein P: Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol. 2009 Mar;28 (2) :65-73. Epub 2009 Jan 20. PMID: 19379668


Tian W and Kyriakides TR: Thrombospondin 2-null mice display an altered brain foreign body response to polyvinyl alcohol sponge implants. Biomed Mater. 2009 Feb;4 (1) :015010. Epub 2008 Nov 20. PMID: 19020342

Krady MM, Zeng J, Yu J, MacLauchlan S, Skokos EA, Tian W, Bornstein P, Sessa WC and Kyriakides TR: Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol. 2008 Sep;173 (3) :879-91. Epub 2008 Aug 7. PMID: 18688033


Roh JD, Nelson GN, Brennan MP, Mirensky TL, Yi T, Hazlett TF, Tellides G, Sinusas AJ, Pober JS, Saltzman WM, Kyriakides TR and Breuer CK: Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model. Biomaterials. 2008 Apr;29 (10) :1454-63. Epub 2007 Dec 27. PMID: 18164056

Jay SM, Skokos E, Laiwalla F, Krady MM and Kyriakides TR: Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation. Am J Pathol. 2007 Aug;171 (2) :632-40. Epub 2007 Jun 7. PMID: 17556592