Publications

Chin JY, Reza F and Glazer PM: Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells. Mol Ther. 2013 Mar;21 (3) :580-7. Epub 2013 Jan 22. PMID: 23337982

Neumeister VM, Sullivan CA, Lindner R, Lezon-Geyda K, Li J, Zavada J, Martel M, Glazer PM, Tuck DP, Rimm DL and Harris L: Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. Breast Cancer Res Treat. 2012 Nov;136 (1) :67-75. Epub 2012 Sep 14. PMID: 22976806

Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH and Glazer PM: Targeting cancer with a lupus autoantibody. Sci Transl Med. 2012 Oct 24;4 (157) :157ra142. PMID: 23100628

McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W and Glazer PM: Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. Gene Ther. 2012 Oct 18; Epub 2012 Oct 18. PMID: 23076379

Rockwell S, Liu Y, Seow HA, Ishiguro K, Baumann RP, Penketh PG, Shyam K, Akintujoye OM, Glazer PM and Sartorelli AC: Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors. Int J Radiat Biol. 2012 Mar;88 (3) :277-85. Epub 2011 Dec 20. PMID: 22111842

Meng F, Evans JW, Bhupathi D, Banica M, Lan L, Lorente G, Duan JX, Cai X, Mowday AM, Guise CP, Maroz A, Anderson RF, Patterson AV, Stachelek GC, Glazer PM, Matteucci MD and Hart CP: Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Mol Cancer Ther. 2012 Mar;11 (3) :740-51. Epub 2011 Dec 6. PMID: 22147748

Rogers FA, Lin SS, Hegan DC, Krause DS and Glazer PM: Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate. Mol Ther. 2012 Jan;20 (1) :109-18. Epub 2011 Aug 9. PMID: 21829173

Lin ZP, Lee Y, Lin F, Belcourt MF, Li P, Cory JG, Glazer PM and Sartorelli AC: Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage. Mol Pharmacol. 2011 Dec;80 (6) :1000-12. Epub 2011 Aug 29. PMID: 21875941

Babar IA, Czochor J, Steinmetz A, Weidhaas JB, Glazer PM and Slack FJ: Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. Cancer Biol Ther. 2011 Nov 15;12 (10) :908-14. Epub 2011 Nov 15. PMID: 22027557

Williams SA, Wilson JB, Clark AP, Mitson-Salazar A, Tomashevski A, Ananth S, Glazer PM, Semmes OJ, Bale AE, Jones NJ and Kupfer GM: Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet. 2011 Nov 15;20 (22) :4395-410. Epub 2011 Aug 24. PMID: 21865299

McNeer NA, Schleifman EB, Glazer PM and Saltzman WM: Polymer delivery systems for site-specific genome editing. J Control Release. 2011 Oct 30;155 (2) :312-6. Epub 2011 May 18. PMID: 21620910

Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL and Glazer PM: Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011 Sep 23;18 (9) :1189-98. PMID: 21944757

Glazer PM, Le QT, Bristow R, Helleday T, Pelroy R and Bernhard EJ: New translational possibilities for microenvironmental modulation of radiosensitivity. Radiat Res. 2011 Sep;176 (3) :412-4. Epub 2011 Jul 8. PMID: 21867431

Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S and Bernhard EJ: Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010. Radiat Res. 2011 Sep;176 (3) :e0016-21. Epub 2011 Jul 8. PMID: 21867428

Lu Y, Chu A, Turker MS and Glazer PM: Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter. Mol Cell Biol. 2011 Aug;31 (16) :3339-50. Epub 2011 Jun 13. PMID: 21670155

Glazer PM, Le QT, Bristow R, Helleday T, Pelroy R and Bernhard EJ: New Translational Possibilities for Microenvironmental Modulation of Radiosensitivity. Radiat Res. 2011 Jul 8; Epub 2011 Jul 8. PMID: 21740252

Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S and Bernhard EJ: Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010. Radiat Res. 2011 Jul 8; Epub 2011 Jul 8. PMID: 21740251

McNeer NA, Chin JY, Schleifman EB, Fields RJ, Glazer PM and Saltzman WM: Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Mol Ther. 2011 Jan;19 (1) :172-80. Epub 2010 Sep 21. PMID: 20859257

Klein TJ and Glazer PM: The tumor microenvironment and DNA repair. Semin Radiat Oncol. 2010 Oct;20 (4) :282-7. PMID: 20832021

Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS and Glazer PM: Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proc Natl Acad Sci U S A. 2010 Feb 2;107 (5) :2201-6. Epub 2010 Jan 19. PMID: 20133863

Rowe BP and Glazer PM: Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms. Breast Cancer Res. 2010;12 (2) :203. Epub 2010 Apr 30. PMID: 20459590

Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB and Glazer PM: Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Res. 2010 Jan 1;70 (1) :409-17. Epub 2009 Dec 22. PMID: 20028873

Crosby ME, Glazer PM and Ivan M: "Micro"-management of DNA repair genes by hypoxia. Cell Cycle. 2009 Dec 15;8 (24) :4009-10. Epub 2009 Dec 30. PMID: 19949295

Lonkar P, Kim KH, Kuan JY, Chin JY, Rogers FA, Knauert MP, Kole R, Nielsen PE and Glazer PM: Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids. Nucleic Acids Res. 2009 Jun;37 (11) :3635-44. Epub 2009 Apr 13. PMID: 19364810

Kim Y, Lin Q, Glazer PM and Yun Z: Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med. 2009 May;9 (4) :425-34. PMID: 19519400

Glazer PM and Bindra RS: Introduction: the evolving picture of the hypoxic tumour microenvironment. Curr Mol Med. 2009 May;9 (4) :399-400. PMID: 19519396

Peterson-Roth E, Brdlik CM and Glazer PM: Src-Induced cisplatin resistance mediated by cell-to-cell communication. Cancer Res. 2009 Apr 15;69 (8) :3619-24. Epub 2009 Apr 7. PMID: 19351863

Chin JY and Glazer PM: Repair of DNA lesions associated with triplex-forming oligonucleotides. Mol Carcinog. 2009 Apr;48 (4) :389-99. PMID: 19072762

Crosby ME, Kulshreshtha R, Ivan M and Glazer PM: MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009 Feb 1;69 (3) :1221-9. Epub 2009 Jan 13. PMID: 19141645

Crosby ME, Devlin CM, Glazer PM, Calin GA and Ivan M: Emerging roles of microRNAs in the molecular responses to hypoxia. Curr Pharm Des. 2009;15 (33) :3861-6. PMID: 19925433

Chin JY, Kuan JY, Lonkar PS, Krause DS, Seidman MM, Peterson KR, Nielsen PE, Kole R and Glazer PM: Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids. Proc Natl Acad Sci U S A. 2008 Sep 9;105 (36) :13514-9. Epub 2008 Aug 29. PMID: 18757759

Marek LR, Kottemann MC, Glazer PM and Bale AE: MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair. DNA Repair (Amst). 2008 Mar 1;7 (3) :476-86. Epub 2008 Feb 6. PMID: 18258493

Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B and Bristow RG: Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res. 2008 Jan 15;68 (2) :605-14. PMID: 18199558

Schleifman EB, Chin JY and Glazer PM: Triplex-mediated gene modification. Methods Mol Biol. 2008;435 :175-90. PMID: 18370076

Bindra RS and Glazer PM: Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network. Cancer Lett. 2007 Jul 8;252 (1) :93-103. Epub 2007 Feb 1. PMID: 17275176

Bindra RS, Crosby ME and Glazer PM: Regulation of DNA repair in hypoxic cancer cells. Cancer Metastasis Rev. 2007 Jun;26 (2) :249-60. PMID: 17415527

Chin JY, Schleifman EB and Glazer PM: Repair and recombination induced by triple helix DNA. Front Biosci. 2007 May 1;12 :4288-97. Epub 2007 May 1. PMID: 17485375

Bindra RS and Glazer PM: Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene. 2007 Mar 29;26 (14) :2048-57. Epub 2006 Sep 25. PMID: 17001309

Huang LE, Bindra RS, Glazer PM and Harris AL: Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression. J Mol Med (Berl). 2007 Feb;85 (2) :139-48. Epub 2006 Dec 20. PMID: 17180667

Kim KH, Nielsen PE and Glazer PM: Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids. Nucleic Acids Res. 2007;35 (22) :7604-13. Epub 2007 Oct 30. PMID: 17977869

Gibson SL, Narayanan L, Hegan DC, Buermeyer AB, Liskay RM and Glazer PM: Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance. Cancer Lett. 2006 Dec 8;244 (2) :195-202. Epub 2006 Jan 19. PMID: 16426742

Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM and Glazer PM: Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis. 2006 Dec;27 (12) :2402-8. Epub 2006 May 25. PMID: 16728433

Smith-Roe SL, Löhr CV, Bildfell RJ, Fischer KA, Hegan DC, Glazer PM and Buermeyer AB: Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Cancer Lett. 2006 Nov 28;244 (1) :79-85. Epub 2006 Jan 20. PMID: 16427736

Bindra RS and Glazer PM: Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biol Ther. 2006 Oct;5 (10) :1400-7. Epub 2006 Oct 30. PMID: 17106239

Gibson SL, Bindra RS and Glazer PM: CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiat Res. 2006 Oct;166 (4) :646-51. PMID: 17007555

Knauert MP, Kalish JM, Hegan DC and Glazer PM: Triplex-stimulated intermolecular recombination at a single-copy genomic target. Mol Ther. 2006 Sep;14 (3) :392-400. Epub 2006 May 30. PMID: 16731047

Zheng H, Wang X, Legerski RJ, Glazer PM and Li L: Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways. DNA Repair (Amst). 2006 May 10;5 (5) :566-74. Epub 2006 Mar 29. PMID: 16569514

Smith-Roe SL, Hegan DC, Glazer PM and Buermeyer AB: Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Mutat Res. 2006 Feb 22;594 (1-2) :101-12. Epub 2005 Oct 26. PMID: 16256150

Shahid KA, Majumdar A, Alam R, Liu ST, Kuan JY, Sui X, Cuenoud B, Glazer PM, Miller PS and Seidman MM: Targeted cross-linking of the human beta-globin gene in living cells mediated by a triple helix forming oligonucleotide. Biochemistry. 2006 Feb 14;45 (6) :1970-8. PMID: 16460044

Kim KH, Nielsen PE and Glazer PM: Site-specific gene modification by PNAs conjugated to psoralen. Biochemistry. 2006 Jan 10;45 (1) :314-23. PMID: 16388608

Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK and Glazer PM: Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res. 2005 Dec 15;65 (24) :11597-604. PMID: 16357170

Gibson SL, Bindra RS and Glazer PM: Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005 Dec 1;65 (23) :10734-41. PMID: 16322218

Kalish JM and Glazer PM: Targeted genome modification via triple helix formation. Ann N Y Acad Sci. 2005 Nov;1058 :151-61. PMID: 16394134

Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG and Glazer PM: Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability. Ann N Y Acad Sci. 2005 Nov;1059 :184-95. PMID: 16382054

Lewin AS, Glazer PM and Milstone LM: Gene therapy for autosomal dominant disorders of keratin. J Investig Dermatol Symp Proc. 2005 Oct;10 (1) :47-61. PMID: 16250209

Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM and Bristow RG: Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol. 2005 Aug;76 (2) :168-76. PMID: 16026872

Rogers FA, Lloyd JA and Glazer PM: Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Curr Med Chem Anticancer Agents. 2005 Jul;5 (4) :319-26. PMID: 16101484

Kalish JM, Seidman MM, Weeks DL and Glazer PM: Triplex-induced recombination and repair in the pyrimidine motif. Nucleic Acids Res. 2005;33 (11) :3492-502. Epub 2005 Jun 16. PMID: 15961731

Knauert MP, Lloyd JA, Rogers FA, Datta HJ, Bennett ML, Weeks DL and Glazer PM: Distance and affinity dependence of triplex-induced recombination. Biochemistry. 2005 Mar 15;44 (10) :3856-64. PMID: 15751961

Bindra RS and Glazer PM: Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutat Res. 2005 Jan 6;569 (1-2) :75-85. PMID: 15603753

Rogers FA, Manoharan M, Rabinovitch P, Ward DC and Glazer PM: Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides. Nucleic Acids Res. 2004;32 (22) :6595-604. Epub 2004 Dec 15. PMID: 15602001

Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG and Glazer PM: Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol. 2004 Oct;24 (19) :8504-18. PMID: 15367671

Jensen R and Glazer PM: Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc Natl Acad Sci U S A. 2004 Apr 20;101 (16) :6134-9. Epub 2004 Apr 6. PMID: 15069205

Kuan JY and Glazer PM: Targeted gene modification using triplex-forming oligonucleotides. Methods Mol Biol. 2004;262 :173-94. PMID: 14769962

Seidman MM and Glazer PM: Setting standards in gene repair. Oligonucleotides. 2004;14 (2) :79. PMID: 15294071

Haffty BG and Glazer PM: Molecular markers in clinical radiation oncology. Oncogene. 2003 Sep 1;22 (37) :5915-25. PMID: 12947398

Seidman MM and Glazer PM: The potential for gene repair via triple helix formation. J Clin Invest. 2003 Aug;112 (4) :487-94. PMID: 12925687

Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S and Glazer PM: Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol. 2003 May;23 (9) :3265-73. PMID: 12697826

Macris MA and Glazer PM: Transcription dependence of chromosomal gene targeting by triplex-forming oligonucleotides. J Biol Chem. 2003 Jan 31;278 (5) :3357-62. Epub 2002 Nov 12. PMID: 12431993

Rogers FA, Vasquez KM, Egholm M and Glazer PM: Site-directed recombination via bifunctional PNA-DNA conjugates. Proc Natl Acad Sci U S A. 2002 Dec 24;99 (26) :16695-700. Epub 2002 Dec 2. PMID: 12461167

Peretz S, Kim C, Rockwell S, Baserga R and Glazer PM: IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Radiat Res. 2002 Aug;158 (2) :174-80. PMID: 12105987

Vasquez KM, Christensen J, Li L, Finch RA and Glazer PM: Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proc Natl Acad Sci U S A. 2002 Apr 30;99 (9) :5848-53. Epub 2002 Apr 23. PMID: 11972036

Haffty BG, Harrold E, Khan AJ, Pathare P, Smith TE, Turner BC, Glazer PM, Ward B, Carter D, Matloff E, Bale AE and Alvarez-Franco M: Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status. Lancet. 2002 Apr 27;359 (9316) :1471-7. PMID: 11988246

Vasquez KM and Glazer PM: Triplex-forming oligonucleotides: principles and applications. Q Rev Biophys. 2002 Feb;35 (1) :89-107. PMID: 11997982

Datta HJ and Glazer PM: Intracellular generation of single-stranded DNA for chromosomal triplex formation and induced recombination. Nucleic Acids Res. 2001 Dec 15;29 (24) :5140-7. PMID: 11812847

Vasquez KM, Dagle JM, Weeks DL and Glazer PM: Chromosome targeting at short polypurine sites by cationic triplex-forming oligonucleotides. J Biol Chem. 2001 Oct 19;276 (42) :38536-41. Epub 2001 Aug 14. PMID: 11504712

Knauert MP and Glazer PM: Triplex forming oligonucleotides: sequence-specific tools for gene targeting. Hum Mol Genet. 2001 Oct 1;10 (20) :2243-51. PMID: 11673407

Gorman L and Glazer PM: Directed gene modification via triple helix formation. Curr Mol Med. 2001 Jul;1 (3) :391-9. PMID: 11899085

Datta HJ, Chan PP, Vasquez KM, Gupta RC and Glazer PM: Triplex-induced recombination in human cell-free extracts. Dependence on XPA and HsRad51. J Biol Chem. 2001 May 25;276 (21) :18018-23. Epub 2001 Feb 27. PMID: 11278954

Xu XS, Narayanan L, Dunklee B, Liskay RM and Glazer PM: Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice. Cancer Res. 2001 May 1;61 (9) :3775-80. PMID: 11325851

Peretz S, Jensen R, Baserga R and Glazer PM: ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc Natl Acad Sci U S A. 2001 Feb 13;98 (4) :1676-81. Epub 2001 Feb 6. PMID: 11172010

Rockwell S, Yuan J, Peretz S and Glazer PM: Genomic instability in cancer. Novartis Found Symp. 2001;240 :133-42; discussion 142-51. PMID: 11727926

Casey BP and Glazer PM: Gene targeting via triple-helix formation. Prog Nucleic Acid Res Mol Biol. 2001;67 :163-92. PMID: 11525382

Vasquez KM, Narayanan L and Glazer PM: Specific mutations induced by triplex-forming oligonucleotides in mice. Science. 2000 Oct 20;290 (5491) :530-3. PMID: 11039937

Zeng M, Narayanan L, Xu XS, Prolla TA, Liskay RM and Glazer PM: Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Res. 2000 Sep 1;60 (17) :4889-93. PMID: 10987303

Yuan J, Narayanan L, Rockwell S and Glazer PM: Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res. 2000 Aug 15;60 (16) :4372-6. PMID: 10969780

Luo Z, Macris MA, Faruqi AF and Glazer PM: High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells. Proc Natl Acad Sci U S A. 2000 Aug 1;97 (16) :9003-8. PMID: 10900269

Turner BC, Gumbs AA, Carter D, Glazer PM and Haffty BG: Cyclin D1 expression and early breast cancer recurrence following lumpectomy and radiation. Int J Radiat Oncol Biol Phys. 2000 Jul 15;47 (5) :1169-76. PMID: 10889369

Andrew SE, Xu XS, Baross-Francis A, Narayanan L, Milhausen K, Liskay RM, Jirik FR and Glazer PM: Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis. 2000 Jul;21 (7) :1291-5. PMID: 10874005

Turner BC, Gumbs AA, Carbone CJ, Carter D, Glazer PM and Haffty BG: Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy. Cancer. 2000 Mar 1;88 (5) :1091-8. PMID: 10699900

Yoo SS, Carter D, Turner BC, Sasaki CT, Son YH, Wilson LD, Glazer PM and Haffty BG: Prognostic significance of cyclin D1 protein levels in early-stage larynx cancer treated with primary radiation. Int J Cancer. 2000 Feb 20;90 (1) :22-8. PMID: 10725854

Faruqi AF, Datta HJ, Carroll D, Seidman MM and Glazer PM: Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway. Mol Cell Biol. 2000 Feb;20 (3) :990-1000. PMID: 10629056

Xu XS, Glazer PM and Wang G: Activation of human gamma-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the gamma-globin gene 5' flanking region. Gene. 2000 Jan 25;242 (1-2) :219-28. PMID: 10721715

Turner BC, Glazer PM and Haffty BG: BRCA1/BRCA2 in breast-conserving therapy. J Clin Oncol. 1999 Nov;17 (11) :3689. PMID: 10550169

Turner BC, Harrold E, Matloff E, Smith T, Gumbs AA, Beinfield M, Ward B, Skolnick M, Glazer PM, Thomas A and Haffty BG: BRCA1/BRCA2 germline mutations in locally recurrent breast cancer patients after lumpectomy and radiation therapy: implications for breast-conserving management in patients with BRCA1/BRCA2 mutations. J Clin Oncol. 1999 Oct;17 (10) :3017-24. PMID: 10506595

Clairmont CA, Narayanan L, Sun KW, Glazer PM and Sweasy JB: The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells. Proc Natl Acad Sci U S A. 1999 Aug 17;96 (17) :9580-5. PMID: 10449735

Wang G, Xu X, Pace B, Dean DA, Glazer PM, Chan P, Goodman SR and Shokolenko I: Peptide nucleic acid (PNA) binding-mediated induction of human gamma-globin gene expression. Nucleic Acids Res. 1999 Jul 1;27 (13) :2806-13. PMID: 10373600

Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM and Arnheim N: Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc Natl Acad Sci U S A. 1999 Jun 8;96 (12) :6850-5. PMID: 10359802

Chan PP, Lin M, Faruqi AF, Powell J, Seidman MM and Glazer PM: Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide. J Biol Chem. 1999 Apr 23;274 (17) :11541-8. PMID: 10206960

Vasquez KM, Wang G, Havre PA and Glazer PM: Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells. Nucleic Acids Res. 1999 Feb 15;27 (4) :1176-81. PMID: 9927753

Lacroix L, Lacoste J, Reddoch JF, Mergny JL, Levy DD, Seidman MM, Matteucci MD and Glazer PM: Triplex formation by oligonucleotides containing 5-(1-propynyl)-2'-deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting. Biochemistry. 1999 Feb 9;38 (6) :1893-901. PMID: 10026270

Turner BC, Zhang J, Gumbs AA, Maher MG, Kaplan L, Carter D, Glazer PM, Hurst HC, Haffty BG and Williams T: Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res. 1998 Dec 1;58 (23) :5466-72. PMID: 9850080

Majumdar A, Khorlin A, Dyatkina N, Lin FL, Powell J, Liu J, Fei Z, Khripine Y, Watanabe KA, George J, Glazer PM and Seidman MM: Targeted gene knockout mediated by triple helix forming oligonucleotides. Nat Genet. 1998 Oct;20 (2) :212-4. PMID: 9771719

Yuan J and Glazer PM: Mutagenesis induced by the tumor microenvironment. Mutat Res. 1998 May 25;400 (1-2) :439-46. PMID: 9685702

Raha M, Lacroix L and Glazer PM: Mutagenesis mediated by triple helix-forming oligonucleotides conjugated to psoralen: effects of linker arm length and sequence context. Photochem Photobiol. 1998 Mar;67 (3) :289-94. PMID: 9523530

Faruqi AF, Egholm M and Glazer PM: Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proc Natl Acad Sci U S A. 1998 Feb 17;95 (4) :1398-403. PMID: 9465026

Fritzell JA, Narayanan L, Baker SM, Bronner CE, Andrew SE, Prolla TA, Bradley A, Jirik FR, Liskay RM and Glazer PM: Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res. 1997 Nov 15;57 (22) :5143-7. PMID: 9371516

Segal DJ, Faruqi AF, Glazer PM and Carroll D: Processing of targeted psoralen cross-links in Xenopus oocytes. Mol Cell Biol. 1997 Nov;17 (11) :6645-52. PMID: 9343428

Turner BC, Haffty BG, Narayanan L, Yuan J, Havre PA, Gumbs AA, Kaplan L, Burgaud JL, Carter D, Baserga R and Glazer PM: Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res. 1997 Aug 1;57 (15) :3079-83. PMID: 9242428

Chan PP and Glazer PM: Triplex DNA: fundamentals, advances, and potential applications for gene therapy. J Mol Med (Berl). 1997 Apr;75 (4) :267-82. PMID: 9151213

Narayanan L, Fritzell JA, Baker SM, Liskay RM and Glazer PM: Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proc Natl Acad Sci U S A. 1997 Apr 1;94 (7) :3122-7. PMID: 9096356

Faruqi AF, Krawczyk SH, Matteucci MD and Glazer PM: Potassium-resistant triple helix formation and improved intracellular gene targeting by oligodeoxyribonucleotides containing 7-deazaxanthine. Nucleic Acids Res. 1997 Feb 1;25 (3) :633-40. PMID: 9016606

Reynolds TY, Rockwell S and Glazer PM: Genetic instability induced by the tumor microenvironment. Cancer Res. 1996 Dec 15;56 (24) :5754-7. PMID: 8971187

Faruqi AF, Seidman MM, Segal DJ, Carroll D and Glazer PM: Recombination induced by triple-helix-targeted DNA damage in mammalian cells. Mol Cell Biol. 1996 Dec;16 (12) :6820-8. PMID: 8943337

Gewirtz AM, Stein CA and Glazer PM: Facilitating oligonucleotide delivery: helping antisense deliver on its promise. Proc Natl Acad Sci U S A. 1996 Apr 16;93 (8) :3161-3. PMID: 8622906

Golub EI, Glazer PM, Ward DC and Radding CM: Rec-A protein-mediated irreversible fixation of an oligodeoxyribonucleotide to specific site in DNA. Mutat Res. 1996 Apr 13;351 (2) :117-24. PMID: 8622705

Raha M, Wang G, Seidman MM and Glazer PM: Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant. Proc Natl Acad Sci U S A. 1996 Apr 2;93 (7) :2941-6. PMID: 8610147

Wang G, Seidman MM and Glazer PM: Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair. Science. 1996 Feb 9;271 (5250) :802-5. PMID: 8628995

Gunther EJ, Havre PA, Gasparro FP and Glazer PM: Triplex-mediated, in vitro targeting of psoralen photoadducts within the genome of a transgenic mouse. Photochem Photobiol. 1996 Feb;63 (2) :207-12. PMID: 8657733

Leach EG, Narayanan L, Havre PA, Gunther EJ, Yeasky TM and Glazer PM: Tissue specificity of spontaneous point mutations in lambda supF transgenic mice. Environ Mol Mutagen. 1996;28 (4) :459-64. PMID: 8991078

Glazer PM, Wang G, Havre PA and Gunther EJ: Targeted mutagenesis mediated by the triple helix formation. Methods Mol Biol. 1996;57 :109-18. PMID: 8849999

Leach EG, Gunther EJ, Yeasky TM, Gibson LH, Yang-Feng TL and Glazer PM: Frequent spontaneous deletions at a shuttle vector locus in transgenic mice. Mutagenesis. 1996 Jan;11 (1) :49-56. PMID: 8671715

Havre PA, Yuan J, Hedrick L, Cho KR and Glazer PM: p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Res. 1995 Oct 1;55 (19) :4420-4. PMID: 7671255

Yuan J, Yeasky TM, Havre PA and Glazer PM: Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis. 1995 Oct;16 (10) :2295-300. PMID: 7586125

Wang G and Glazer PM: Altered repair of targeted psoralen photoadducts in the context of an oligonucleotide-mediated triple helix. J Biol Chem. 1995 Sep 22;270 (38) :22595-601. PMID: 7673252

Gunther EJ, Yeasky TM, Gasparro FP and Glazer PM: Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations at cross-linkable sites induced by offoadducts as well as cross-links. Cancer Res. 1995 Mar 15;55 (6) :1283-8. PMID: 7882323

Wang G, Levy DD, Seidman MM and Glazer PM: Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation. Mol Cell Biol. 1995 Mar;15 (3) :1759-68. PMID: 7862165

Yuan J, Yeasky TM, Rhee MC and Glazer PM: Frequent T:A-->G:C transversions in X-irradiated mouse cells. Carcinogenesis. 1995 Jan;16 (1) :83-8. PMID: 7834808

Gasparro FP, Havre PA, Olack GA, Gunther EJ and Glazer PM: Site-specific targeting of psoralen photoadducts with a triple helix-forming oligonucleotide: characterization of psoralen monoadduct and crosslink formation. Nucleic Acids Res. 1994 Jul 25;22 (14) :2845-52. PMID: 8052539

Havre PA and Glazer PM: Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide. J Virol. 1993 Dec;67 (12) :7324-31. PMID: 8230456

Havre PA, Gunther EJ, Gasparro FP and Glazer PM: Targeted mutagenesis of DNA using triple helix-forming oligonucleotides linked to psoralen. Proc Natl Acad Sci U S A. 1993 Aug 15;90 (16) :7879-83. PMID: 8356097

Gunther EJ, Murray NE and Glazer PM: High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen. Nucleic Acids Res. 1993 Aug 11;21 (16) :3903-4. PMID: 8396240

Summers WC, Glazer PM and Malkevich D: Lambda phage shuttle vectors for analysis of mutations in mammalian cells in culture and in transgenic mice. Mutat Res. 1989 Mar-May;220 (2-3) :263-8. PMID: 2522589

Glazer PM, Greggio NA, Metherall JE and Summers WC: UV-induced DNA-binding proteins in human cells. Proc Natl Acad Sci U S A. 1989 Feb;86 (4) :1163-7. PMID: 2919165

Lacy J, Summers WP, Watson M, Glazer PM and Summers WC: Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line. Proc Natl Acad Sci U S A. 1987 Aug;84 (16) :5838-42. PMID: 3039510

Glazer PM, Sarkar SN, Chisholm GE and Summers WC: DNA mismatch repair detected in human cell extracts. Mol Cell Biol. 1987 Jan;7 (1) :218-24. PMID: 3031461

Glazer PM, Sarkar SN and Summers WC: Detection and analysis of UV-induced mutations in mammalian cell DNA using a lambda phage shuttle vector. Proc Natl Acad Sci U S A. 1986 Feb;83 (4) :1041-4. PMID: 2937054

Summers WC, Sarkar SN and Glazer PM: Direct and inducible mutagenesis in mammalian cells. Cancer Surv. 1985;4 (3) :517-28. PMID: 3916654

Glazer PM and Summers WC: Oncogene expression in isogenic, EBV-positive and -negative Burkitt lymphoma cell lines. Intervirology. 1985;23 (2) :82-9. PMID: 2984143