Michael Simons MD, FACC, FAHA

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Vascular Biology and Therapeutics Program

Animal Organogenesis

Cell Biology: Developmental Cell Biology and Genetics

Internal Medicine: Cardiovascular Medicine: Yale Cardiovascular Research Center | Simons Lab

Research Interests

Angiogenesis; Arteriogenesis; Lymphangiogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis more...


  • B.S., Massachusetts Institute of Technology, 1980
  • M.D., Yale University, 1984

Selected Publications

  • Elfenbein A, Lanahan AA, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M. Syndecan 4 regulates endothelial FGFR1 signaling by directing macropinocytosis. Science Signaling 2012; 5:ra36. doi: 10.1126/scisignal.2002495 PMID: 22569333
  • Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A and Simons M. Endothelial NF?B -dependent regulation of arteriogenesis and branching. Circulation 2012; 126:2589-2600; PMID: 23091063 doi: 10.1161/CIRCULATIONAHA.112.119321
  • Chen P-Y*, Qin L*, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGFß signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Reports 2012; 2:1684-96; http://dx.doi.org/10.1016/j.celrep.2012.10.021.



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