Arya Mani, MD, FACC, FAHA

Associate Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program; Director, Cardiovascular Module

Departments & Organizations


Heart & Vascular Center, Yale-New Haven Hospital

Internal Medicine: Cardiovascular Medicine: Cardiomyopathy Inherited Cardiovascular Disease Program; Cardiovascular Genetics Program; Echocardiography (Cardiac Imaging)

Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

Yale Medical Group


My laboratory’s major focus is the identification of genetic causes of major cardiovascular disorders and the elucidation of their pathophysiology. Through collaborative efforts with physicians and scientist across the world we have recruited large populations of patients and families with early onset coronary artery disease and metabolic syndrome and have successfully mapped and identified number of genes for these diseases. An ongoing effort in the laboratory is to understand the function of these genes and how the mutations affect the phenotype, using mouse and zebrafish models.

Having unique access to the genetic study population, we have had the opportunity to carry out clinical studies to investigate the disease mechanisms and have made numerous novel discoveries. We are actively investigating pathways that regulate insulin signaling, glucose metabolism, VLDL and LDL syntheis and clearance and atherosclerosis.

In addition, my laboratory studies the genetic causes of adult congenital heart disease, such as bicuspid aortic valve, atrial fibrillation and patent ductus arteriosus.

Education & Training

MD Johannes-Gutenberg-University of Mainz (1991)
Fellow Yale University School of Medicine
Resident Yale-New Haven Hospital
Fellow University of Erlangen-Nuernberg
Board Certification AB of Internal Medicine, Cardiovascular Disease (2001)
Board Certification AB of Internal Medicine, Internal Medicine (1996)
Board Certification National Board of Echocardiography, Adult Transthoracic Plus Stress Echocardiography (2008)

International Activity

  • The genetic etiology of coronary artery disease Mombay, India (2001)

    Identification of genetic causes of premature coronary artery disease in South Asians

  • Genetics of Cardiovascular Diseases Isfahan, Iran; Shiraz, Iran; Tehran, Iran (1998)

    Study of genetic causes of coronary artery disease and congenital heart defect

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Contact Info

Arya Mani, MD, FACC, FAHA
Patient Care Locations
Yale Nuclear CardiologyYale-New Haven Hospital
20 York Street

New Haven, CT 06510
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Yale CardiologyYale Physicians Building
800 Howard Avenue, Ste 2nd floor

New Haven, CT 06519
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Lab Location
Mani's Lab300 George Street, Ste 759
New Haven, CT 06511
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Mailing Address
PO Box 208056
333 Cedar Street

New Haven, CT 06520-8056