Ruth Halaban PhD

Senior Research Scientist in Dermatology

Departments & Organizations

Melanoma Program

Cancer Genetics & Genomics

Dermatology: SPORE in Skin Cancer

Gene Regulation and Functional Genomics


Research Interests

Genes controlling differentiation, proliferation; malignant transformation of melanocytes; Growth factors and receptor kinases; Signal transduction; Epigenetic modification and gene expression; Markers for melanoma; Next-Generation sequencing; mutations  more...


Education

  • Ph.D., Princeton University, 1968

Selected Publications

  • Shi, H., G. Moriceau, X. Kong, R.C. Koya, R. Nazarian, G.M. Pupo, A. Bacchiocchi, K.B. Dahlman, B. Chmielowski, J.A. Sosman, R. Halaban, R.F. Kefford, G.V. Long, A. Ribas, and R.S. Lo. 2012. Preexisting MEK1 Exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. Cancer Discov. 2:414-424.
  • Davis, M.J., B.H. Ha, E.C. Holman, R. Halaban, J. Schlessinger, and T.J. Boggon. 2013. RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci U S A. 110:912-917.
  • Ha, B.H., M.J. Davis, C. Chen, H.J. Lou, J. Gao, R. Zhang, M. Krauthammer, R. Halaban, J. Schlessinger, B.E. Turk, and T.J. Boggon. 2012. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A.

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