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Developmental Therapeutics

David Adam Spiegel

Professor of Chemistry

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and PhysiologyHIV/AIDS

Developmental Therapeutics

Molecular Virology


Research Interests

Design of novel molecules that enhance the recognition of various pathogens, including viruses, by the human immune system more...


Selected Publications

  • Spiegel DA. Synthetic Immunology to Engineer Human Immunity. Nature Chemical Biology. 2010; 6; 871-872. Chosen as one of eight recipients of the 2010 Grand Challenges in Chemical Biology Competition.
  • Nelson JW, Chamessian AG, McEnaney PJ, Kazmierczak BI, Spiegel DA. A Biosynthetic Strategy for Re-engineering the S. aureus Cell Wall with Non-Native Small Molecules. ACS Chemical Biology. 2010, 1147-1155.
  • Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A,** Jorgensen WL, Lubkowski J, Spiegel DA. A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules. Journal of the American Chemical Society. 2010, 12711-12716.

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