Carl Hashimoto, PhD

Professor of Cell Biology; Assistant Dean Yale College; Assistant Dean Graduate School

Research Interests

Cells; Endocrine System Diseases; Genetics; Molecular Biology; Tissues; Developmental Biology; Neurodegenerative Diseases; Intercellular Signaling Peptides and Proteins

Research Organizations

Animal Organogenesis

Cell Biology: Developmental Cell Biology and Genetics

Research Summary

Proteolysis drives a wide range of biological processes from the cell cycle to embryonic patterning, and is thought to mediate complex brain functions such as learning and memory. Not surprisingly, then, dysfunction in proteolysis is associated with many human disorders, including cancer and dementia. My laboratory is generally interested in cellular and developmental processes that are regulated by proteolysis.

Extensive Research Description

The coordinated action of proteases and their inhibitors plays an important role in morphogenesis and function of many organs. Disruption of the protease-inhibitor balance is associated with diverse pathologies including cancer. My laboratory is particularly interested in biological processes and diseases involving protease inhibitors known as serpins, which uniquely inactivate proteases by acting as a suicide substrate to trap their target in a tight complex. Perhaps the best known serpins function in blood clotting, inflammation, and other host defense reactions; however, the biological function of many more serpins is unknown. We are
using genetic and functional genomic approaches to define biological roles for serpins. These studies have already identified a serpin important for morphogenesis and tissue remodeling events during development. Diverse pathologies such as liver cirrhosis, thrombosis, and neurodegeneration are associated with mutant serpins that spontaneously polymerize to form intracellular inclusions. We are interested in understanding how cells deal with these intracellular inclusions and in exploring genetic strategies to revert disease phenotypes resulting from serpin polymerization.
Identifying a serpin-regulated proteolytic cascade involved in innate immunity.
Understanding a cell death pathway controlled by a serpin.
Exploring the role of insulin degrading enzyme in insulin signaling.

Selected Publications

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Contact Info

Carl Hashimoto, PhD
Office Location
Science Education and Undergraduate ResearchSheffield-Sterling-Strathcona
1 Prospect Street, Rm 26

New Haven, CT 06511
Mailing Address
1 Prospect Street
New Haven, CT 06511-6816