Satinder Kaur Singh, PhD

Associate Professor

Departments & Organizations

Cellular & Molecular Physiology

Faculty Research

Interdepartmental Neuroscience Program

Structural Biology

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS): Membrane Biology; Neuroscience | Molecular Medicine, Pharmacology, and Physiology: Ion Channels, Pumps and Transporters; Neurobiology, Neural Networks and Neuropharmacology; Receptors and Signal Transduction; Structural Biology

Office of Cooperative Research

Biography

Satinder was born in Boston, MA and moved, as a teenager, to Minneapolis, MN, with her family. She received her doctoral degree in Biochemistry & Molecular Biophysics from the University of Minnesota – Twin Cities, supported by an HHMI Predoctoral Fellowship. She has had a long-standing interest in the molecular mechanisms of neuropsychiatric disease, particularly in the role that the biogenic amines play. As a postdoctoral fellow, she combined her knowledge of neuropsychopharmacology and enzymology with X-ray crystallography to develop molecular models of transport and inhibition for LeuT, a bacterial orthologue of neurotransmitter sodium symporters (NSS). At Yale, Satinder has been concentrating on eukaryotic NSS members, specifically those that transport the biogenic amines serotonin (SERT) and dopamine (DAT).

Education & Training

PhD University of Minnesota (2002)
BS University of Minnesota (1995)
Postdoctoral Fellow Oregon Health and Science University
Postdoctoral Fellow Columbia University

Honors & Recognition

  • NARSAD Independent Investigator AwardBrain and Behavior Research Foundation (2015)

  • Sloan Research Fellowship AwardAlfred P. Sloan Foundation (2012)

  • Goodman & Gilman Yale Scholar AwardYale University School of Medicine (2010)

  • NIH/NIMH K99/R00 "Pathway to Independence Award"National Institutes of Health (2008)

  • NIH/NINDS Individual NRSA Postdoctoral FellowshipNational Institutes of Health (2003)

  • NSF Graduate Research Fellowship (declined)National Science Foundation (1997)

  • HHMI Predoctoral FellowshipHoward Hughes Medical Institute (1997)

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Contact Info

Satinder Kaur Singh, PhD
Office Location
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste Room SHM BE11A

New Haven, CT 06510
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Mailing Address
333 Cedar Street, SHM B147
P.O. Box 208026

New Haven, CT 06520
Research Image 1

Conformational dynamics of LeuT embedded in a nanoscale lipid bilayer as assessed by hydrogen-deuterium exchange (HDX-MS) kinetics. LeuT is a prokaryotic homolog of the human dopamine and serotonin transporters, currently the primary protein targets of the lab. Individual figures from Adhikary et al, (2017) are overlaid onto an image of the synaptic cleft.