Farren Isaacs

(leave of absence); Asst Prof Mol Cell & Dev Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Genetics and Genomics | Biochemistry, Biophysics and Structural Biology

Molecular, Cellular, and Developmental Biology

Center for RNA Science and Medicine, Yale

Research Interests

Synthetic Biology; Systems Biology; Genomics; Biotechnology more...


  • M.S., Boston University,
  • B.S., University of Pennsylvania,
  • Ph.D., Boston University,

Selected Publications

  • Isaacs FJ*, Carr PA*, Wang HH*, Lajoie MJ, Sterling B, Kraal L, Tolonen AC, Gianoulis TA, Goodman DB, Reppas NB, Emig CJ, Bang D, Hwang SJ, Jewett MC, Jacobson JM, Church GM. (2011) Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science, 333(6040):348-53. PMID: 21764749.
  • Wang HH*, Isaacs FJ*, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM (2009) Programming cells by multiplex genome engineering and accelerated evolution. Nature, 460(7257):894-8.
  • Isaacs FJ, Dwyer DJ, Collins JJ (2006) RNA Synthetic Biology. Nature Biotechnology, 24:545-554.



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