Tobias Walther PhD

Associate Professor of Cell Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Cell Biology: Membrane Traffic | Walther Lab

Research Interests

Organelle homeostasis; Plasma membrane organization; Lipid metabolism, Lipid Droplets; Eisosomes; Sphingolipid metabolism; Systematic genetics; RNAi screening; Mass-spectrometry based proteomics more...


  • Ph.D., European Molecular Biology Laboratorium (EMBL), 2002

Selected Publications

  • Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV Jr, Walther TC. Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase. Cell Metab.2011 Oct 5;14(4):504-15.
  • Farese, R.V. † and Walther, T.C†. Lipid Droplets finally get a little R-E-S-P-E-C-T. Cell (2009), 139: 855-860.
  • Berchtold, D., and Walther, T.C. †: TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain, Mol. Biol. of the Cell, (2009), 20:1565-75.



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