2017
Modeling Major Adverse Outcomes of Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Catheterization
Jayaram N, Spertus JA, Kennedy KF, Vincent R, Martin GR, Curtis JP, Nykanen D, Moore PM, Bergersen L. Modeling Major Adverse Outcomes of Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Catheterization. Circulation 2017, 136: 2009-2019. PMID: 28882885, PMCID: PMC5698125, DOI: 10.1161/circulationaha.117.027714.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsBlood CoagulationBlood Coagulation DisordersCardiac CatheterizationChi-Square DistributionChildChild, PreschoolFemaleHeart Defects, CongenitalHemodynamicsHumansInfantInfant, NewbornKidneyLogistic ModelsMaleMultivariate AnalysisOdds RatioRegistriesRenal InsufficiencyReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsProcedure-type risk categoriesMajor adverse outcomesMajor adverse eventsCardiac catheterizationCongenital heart diseaseAdverse eventsValidation cohortAdverse outcomesCongenital cardiac catheterizationIMPACT RegistryRisk categoriesHemodynamic vulnerabilityHeart diseaseMultivariable hierarchical logistic regression modelsFinal risk-adjustment modelSingle ventricle physiologyRisk-adjusted outcomesHierarchical logistic regression modelsRisk-adjustment modelsLogistic regression modelsRisk standardizationRenal insufficiencyAdult patientsConsecutive patientsPatient characteristics
2016
Development and validation of a simple risk score to predict 30‐day readmission after percutaneous coronary intervention in a cohort of medicare patients
Minges KE, Herrin J, Fiorilli PN, Curtis JP. Development and validation of a simple risk score to predict 30‐day readmission after percutaneous coronary intervention in a cohort of medicare patients. Catheterization And Cardiovascular Interventions 2016, 89: 955-963. PMID: 27515069, PMCID: PMC5397364, DOI: 10.1002/ccd.26701.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlgorithmsDecision Support TechniquesFemaleHumansLogistic ModelsMaleMedicareMultivariate AnalysisOdds RatioPatient ReadmissionPercutaneous Coronary InterventionPredictive Value of TestsRegistriesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsRisk of readmissionPCI patientsRisk scoreMultivariable logistic regression modelRisk score developmentDays of dischargeSimple risk scoreTime of dischargeModel c-statisticLogistic regression modelsStepwise selection modelCathPCI RegistryHospital dischargeReadmission ratesClinical factorsRevascularization proceduresValidation cohortC-statisticReadmissionHigh riskMedicare feeLower riskService claimsPatientsCohortImpact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006–2011)
Arora S, Panaich SS, Patel N, Patel NJ, Lahewala S, Thakkar B, Savani C, Jhamnani S, Singh V, Patel N, Patel S, Sonani R, Patel A, Tripathi B, Deshmukh A, Chothani A, Patel J, Bhatt P, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Mena CI, Schreiber T, Grines C, Cleman M, Forrest JK, Badheka AO. Impact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006–2011). Catheterization And Cardiovascular Interventions 2016, 88: 605-616. PMID: 26914274, DOI: 10.1002/ccd.26452.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmputation, SurgicalCross-Sectional StudiesDatabases, FactualDrug CostsEndovascular ProceduresFemaleHospital CostsHospital MortalityHumansLimb SalvageLogistic ModelsLower ExtremityMaleMiddle AgedMultivariate AnalysisOdds RatioPeripheral Arterial DiseasePlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexPropensity ScoreRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsGlycoprotein IIb/IIIa inhibitorsPeripheral endovascular interventionsHospital mortalityHospitalization costsEndovascular interventionGPI useAmputation rateUtilization Project Nationwide Inpatient Sample databaseTwo-level hierarchical multivariateIIb/IIIa inhibitorsNationwide Inpatient Sample databaseLower amputation ratesPaucity of dataHospital outcomesPostprocedural complicationsSecondary outcomesPropensity matchingStudy cohortHealthcare costsICD-9Multivariate analysisStudy outcomesSample databaseMortalityHierarchical multivariate
2014
Clinical Effectiveness of Cardiac Resynchronization Therapy Versus Medical Therapy Alone Among Patients With Heart Failure
Khazanie P, Hammill BG, Qualls LG, Fonarow GC, Hammill SC, Heidenreich PA, Al-Khatib SM, Piccini JP, Masoudi FA, Peterson PN, Curtis JP, Hernandez AF, Curtis LH. Clinical Effectiveness of Cardiac Resynchronization Therapy Versus Medical Therapy Alone Among Patients With Heart Failure. Circulation Heart Failure 2014, 7: 926-934. PMID: 25227768, PMCID: PMC4244212, DOI: 10.1161/circheartfailure.113.000838.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Resynchronization TherapyDefibrillators, ImplantableHeart FailureHospitalizationHumansMultivariate AnalysisRegistriesTreatment OutcomeConceptsAcute Decompensated Heart Failure National RegistryImplantable Cardioverter-Defibrillator RegistryHeart failureMedical therapyCardiovascular readmissionCause readmissionQRS durationNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryLeft ventricular ejection fractionCox proportional hazards modelHistorical control cohortOptimal medical therapyCardiac resynchronization therapyVentricular ejection fractionProportional hazards modelMultivariable adjustmentEjection fractionICD RegistryResynchronization therapyClinical effectivenessControl cohortNational registryClinical trialsLower riskHazards modelSurvival After Primary Prevention Implantable Cardioverter-Defibrillator Placement Among Patients With Chronic Kidney Disease
Hess PL, Hellkamp AS, Peterson ED, Sanders GD, Al-Khalidi HR, Curtis LH, Hammill BG, Pun PH, Curtis JP, Anstrom KJ, Hammill SC, Al-Khatib SM. Survival After Primary Prevention Implantable Cardioverter-Defibrillator Placement Among Patients With Chronic Kidney Disease. Circulation Arrhythmia And Electrophysiology 2014, 7: 793-799. PMID: 25038119, PMCID: PMC4206571, DOI: 10.1161/circep.114.001455.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathChi-Square DistributionComorbidityDeath, Sudden, CardiacDefibrillators, ImplantableElectric CountershockFemaleGlomerular Filtration RateHeart FailureHumansKaplan-Meier EstimateKidneyLinear ModelsMaleMiddle AgedMultivariate AnalysisPatient SelectionPrimary PreventionProportional Hazards ModelsProsthesis DesignRegistriesRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUnited StatesConceptsChronic kidney diseasePrimary prevention ICD placementRisk of deathICD placementCKD severityKidney diseaseNational Cardiovascular Data Registry ICD RegistryPrimary prevention implantable cardioverter-defibrillator placementGlomerular filtration rate 30Implantable cardioverter-defibrillator candidatesEnd-stage renal diseaseImplantable cardioverter-defibrillator placementSocial Security Death Master FileHeart failure symptomsLow ejection fractionGlomerular filtration rateRate of deathDeath Master FileICD candidacyCKD stageDiabetes mellitusEjection fractionICD RegistryRenal diseaseSerum sodium
2013
Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators
Akar JG, Bao H, Jones P, Wang Y, Chaudhry SI, Varosy P, Masoudi FA, Stein K, Saxon LA, Curtis JP. Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators. Circulation 2013, 128: 2372-2383. PMID: 24043302, DOI: 10.1161/circulationaha.113.002481.Peer-Reviewed Original ResearchConceptsMedian odds ratioOdds ratioNational Cardiovascular Data Registry ICD RegistryRemote patient monitoringMultivariable logistic regressionHealth-related factorsImplanted cardioverter defibrillatorEligible patientsICD RegistryLack of enrollmentCurrent guidelinesCardioverter defibrillatorPatientsLogistic regressionLocal practice environmentMajor causeHealth insuranceSubsequent activationEnrollmentPractice environmentPatient monitoringPhysiciansActivationRPM systemSuccessful useCardiac Perforation From Implantable Cardioverter-Defibrillator Lead Placement
Hsu JC, Varosy PD, Bao H, Dewland TA, Curtis JP, Marcus GM. Cardiac Perforation From Implantable Cardioverter-Defibrillator Lead Placement. Circulation Cardiovascular Quality And Outcomes 2013, 6: 582-590. PMID: 24002030, DOI: 10.1161/circoutcomes.113.000299.Peer-Reviewed Original ResearchConceptsPredictors of perforationCardiac perforationICD recipientsMajor complicationsGreater oddsImplantable cardioverter defibrillator lead placementHigher left ventricular ejection fractionFirst-time ICD recipientsLeft ventricular ejection fractionHierarchical multivariable logistic regressionHeart failure classICD lead implantationAssociated adverse eventsVentricular ejection fractionMultivariable logistic regressionLength of stayBundle branch blockCardiac bypass surgeryHospital mortalityHospital deathHospital stayBypass surgeryFeared complicationMultivariable adjustmentAdverse eventsEnhanced Mortality Risk Prediction With a Focus on High-Risk Percutaneous Coronary Intervention Results From 1,208,137 Procedures in the NCDR (National Cardiovascular Data Registry)
Brennan JM, Curtis JP, Dai D, Fitzgerald S, Khandelwal AK, Spertus JA, Rao SV, Singh M, Shaw RE, Ho KK, Krone RJ, Weintraub WS, Weaver WD, Peterson ED, Registry C. Enhanced Mortality Risk Prediction With a Focus on High-Risk Percutaneous Coronary Intervention Results From 1,208,137 Procedures in the NCDR (National Cardiovascular Data Registry). JACC Cardiovascular Interventions 2013, 6: 790-799. PMID: 23968699, DOI: 10.1016/j.jcin.2013.03.020.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary AngiographyCoronary Artery DiseaseDiscriminant AnalysisFemaleHeart ArrestHospital MortalityHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPercutaneous Coronary InterventionRegistriesReproducibility of ResultsRisk AssessmentRisk FactorsShock, CardiogenicTime FactorsTreatment OutcomeUnited StatesConceptsPercutaneous coronary interventionRecent cardiac arrestCardiogenic shockInpatient mortalityCardiac arrestPercutaneous Coronary Intervention ResultsBedside risk scoreMain lesion locationHigh-risk patientsChronic total occlusionHigh clinical riskRisk of deathHospital mortality risk modelPre-specified patient subgroupsMortality risk predictionMortality risk modelData collection formRisk prediction modelPCI riskHospital mortalityProcedural mortalityAngiographic predictorsCoronary interventionRisk patientsClinical stabilityDeterminants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®
Fazel R, Curtis J, Wang Y, Einstein AJ, Smith‐Bindman R, Tsai TT, Chen J, Shah ND, Krumholz HM, Nallamothu BK. Determinants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®. Catheterization And Cardiovascular Interventions 2013, 82: 1091-1105. PMID: 23703793, DOI: 10.1002/ccd.24996.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInvasive coronary angiographyHospital-level factorsFluoroscopy timePrior CABGCoronary interventionPrior coronary artery bypassRadiation exposureCoronary artery bypassNumerous clinical scenariosArtery bypassCathPCI RegistryPatient characteristicsCoronary angiographyPCI proceduresModifiable determinantsPatientsClinical scenariosModifiable sourceProcedure complexityCABGMinutesInterventionExposureWide variationSafety of Pacemaker Implantation in Nonagenarians
Mandawat A, Curtis JP, Mandawat A, Njike VY, Lampert R. Safety of Pacemaker Implantation in Nonagenarians. Circulation 2013, 127: 1453-1465. PMID: 23513066, DOI: 10.1161/circulationaha.113.001434.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overArrhythmias, CardiacComorbidityCross-Sectional StudiesFemaleHealth Care CostsHospital MortalityHumansLength of StayLinear ModelsLogistic ModelsMaleMultivariate AnalysisOutcome and Process Assessment, Health CarePacemaker, ArtificialPredictive Value of TestsUnited StatesConceptsLength of stayYears of ageSevere comorbiditiesPacemaker implantationUtilization Project Nationwide Inpatient SampleInitial pacemaker implantationCase-mix variationMantel-Haenszel testStepwise linear regression modelHospital mortalityUnadjusted mortalityComplication rateMultivariable analysisUnadjusted outcomesInpatient SampleHealthcare costsPatientsComorbiditiesHierarchical logistic modelsStayNonagenariansMortalityAgeOutcomesComplications
2012
Bleeding and vascular complications at the femoral access site following percutaneous coronary intervention (PCI): an evaluation of hemostasis strategies.
Tavris DR, Wang Y, Jacobs S, Gallauresi B, Curtis J, Messenger J, Resnic FS, Fitzgerald S. Bleeding and vascular complications at the femoral access site following percutaneous coronary intervention (PCI): an evaluation of hemostasis strategies. Journal Of Invasive Cardiology 2012, 24: 328-34. PMID: 22781471.Peer-Reviewed Original ResearchConceptsVascular closure deviceFemoral access siteHemostasis strategyPercutaneous coronary interventionVascular complicationsComplication rateSafety profileAccess siteHierarchical multiple logistic regression analysisMultiple logistic regression analysisPercutaneous coronary intervention (PCI) proceduresVascular complication ratesReduced complication ratesGood safety profileFemoral artery occlusionCoronary intervention proceduresRepresentative observational studyLogistic regression analysisRegression analysisType of hemostasisArtery dissectionCathPCI RegistryArtery occlusionCardiac catheterizationCoronary interventionVariation in Use of Dual-Chamber Implantable Cardioverter-Defibrillators: Results From the National Cardiovascular Data Registry
Matlock DD, Peterson PN, Wang Y, Curtis JP, Reynolds MR, Varosy PD, Masoudi FA. Variation in Use of Dual-Chamber Implantable Cardioverter-Defibrillators: Results From the National Cardiovascular Data Registry. JAMA Internal Medicine 2012, 172: 634-641. PMID: 22529229, PMCID: PMC8317619, DOI: 10.1001/archinternmed.2012.394.Peer-Reviewed Original ResearchMeSH KeywordsAgedCluster AnalysisComorbidityCross-Sectional StudiesDeath, Sudden, CardiacDefibrillators, ImplantableEquipment DesignFemaleHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisNew EnglandOdds RatioPacemaker, ArtificialPacific StatesPredictive Value of TestsPrimary PreventionRegistriesConceptsDual-chamber ICDDual-chamber devicesPrimary preventionDual-Chamber Implantable CardioverterMultivariate hierarchical logistic regressionNational Cardiovascular Data RegistrySingle-chamber ICDHospital-level variationStrong independent predictorSudden cardiac deathCross-sectional studyHealth care providersHierarchical logistic regressionPacing indicationCardiac deathHospital clusteringIndependent predictorsPatient factorsPhysician factorsHospital ratesImplantable cardioverterCare providersIdentical patientsCurrent evidenceData registry
2011
Factors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention
Khawaja FJ, Shah ND, Lennon RJ, Slusser JP, Alkatib AA, Rihal CS, Gersh BJ, Montori VM, Holmes DR, Bell MR, Curtis JP, Krumholz HM, Ting HH. Factors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 172: 112-117. PMID: 22123752, PMCID: PMC3688066, DOI: 10.1001/archinternmed.2011.569.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryCoronary Artery BypassEducational StatusFemaleFollow-Up StudiesHeart FailureHumansIschemic Attack, TransientKidney DiseasesLength of StayMaleMedicareMultivariate AnalysisMyocardial InfarctionNeoplasm MetastasisPatient ReadmissionPeptic UlcerProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRegistriesSex FactorsStrokeUnited StatesConceptsPercutaneous coronary interventionThirty-day readmissionReadmission ratesCoronary interventionHigh riskChronic obstructive pulmonary diseaseThirty-day readmission ratesCox proportional hazards modelMultivariate logistic regression modelTransient ischemic attackCongestive heart failureObstructive pulmonary diseasePeptic ulcer diseaseSevere renal diseaseAcute myocardial infarctionLength of stayMain outcome measuresProportional hazards modelSaint Mary's HospitalLogistic regression modelsIschemic attackTime-dependent covariatesUnstable anginaCerebrovascular accidentHeart failureInfluence of Age on Perioperative Complications Among Patients Undergoing Implantable Cardioverter-Defibrillators for Primary Prevention in the United States
Tsai V, Goldstein MK, Hsia HH, Wang Y, Curtis J, Heidenreich PA. Influence of Age on Perioperative Complications Among Patients Undergoing Implantable Cardioverter-Defibrillators for Primary Prevention in the United States. Circulation Cardiovascular Quality And Outcomes 2011, 4: 549-556. PMID: 21878667, DOI: 10.1161/circoutcomes.110.959205.Peer-Reviewed Original ResearchConceptsAdverse eventsICD RegistryPrimary prevention ICD recipientsEnd pointImplantable cardioverter defibrillator recipientsPatients 85 yearsPrimary prevention patientsMinor adverse eventsPrimary end pointSecondary end pointsMajor adverse eventsCongestive heart failureCoronary artery diseaseLength of stayInfluence of ageHospital mortalityICD trialsPerioperative complicationsPeriprocedural complicationsArtery diseaseHeart failureICD recipientsRenal diseaseIncreased oddsAtrial fibrillation
2009
Use of implantable cardioverter defibrillators for primary prevention in the community: Do women and men equally meet trial enrollment criteria?
Daugherty SL, Peterson PN, Wang Y, Curtis JP, Heidenreich PA, Lindenfeld J, Vidaillet HJ, Masoudi FA, behalf of the NCDR O. Use of implantable cardioverter defibrillators for primary prevention in the community: Do women and men equally meet trial enrollment criteria? American Heart Journal 2009, 158: 224-229. PMID: 19619698, DOI: 10.1016/j.ahj.2009.05.018.Peer-Reviewed Original ResearchConceptsTrial enrollment criteriaPrimary prevention ICD implantationEnrollment criteriaICD implantationMADIT-IIMultivariable analysisPrimary preventionTrial criteriaNational Cardiovascular Data Registry ICD RegistryPrimary prevention ICD placementImplantable cardioverter defibrillator implantationSCD-HeFT trialsCardioverter-defibrillator implantationSudden cardiac deathImplantable cardioverter defibrillatorDefibrillator implantationSCD-HeFTYounger patientsCardiac deathICD RegistryICD placementNational cohortCardioverter defibrillatorOlder womenPatients
2008
Factors Associated With Longer Time From Symptom Onset to Hospital Presentation for Patients With ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Lichtman JH, Nallamothu BK, Sullivan MD, Gersh BJ, Roger VL, Curtis JP, Krumholz HM. Factors Associated With Longer Time From Symptom Onset to Hospital Presentation for Patients With ST-Elevation Myocardial Infarction. JAMA Internal Medicine 2008, 168: 959-968. PMID: 18474760, PMCID: PMC4858313, DOI: 10.1001/archinte.168.9.959.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionMyocardial infarctionHospital presentationSymptom onsetPatient subgroupsRisk factorsOnset of symptomsQuality of careRace/ethnicityNational registryPatient responsivenessInfarctionPatientsReference groupSubgroupsWomenMenCareOnsetMinutesPresentationYearsHoursGeometric meanDiabeticsDelay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Nallamothu BK, Gersh BJ, Roger VL, Lichtman JH, Curtis JP, Krumholz HM. Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction. The American Journal Of Medicine 2008, 121: 316-323. PMID: 18374691, PMCID: PMC2373574, DOI: 10.1016/j.amjmed.2007.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryEarly DiagnosisElectrocardiographyEmergency Medical ServicesEmergency Service, HospitalFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationOdds RatioProbabilityRegistriesRetrospective StudiesRisk FactorsSurvival AnalysisThrombolytic TherapyTime FactorsTreatment OutcomeConceptsST-elevation myocardial infarctionReperfusion therapyHospital presentationBalloon timeSymptom onsetLonger doorMyocardial infarctionDrug timePrimary reperfusion therapyCohort studyLate presentersNeedle timeNational registryPatientsReduced likelihoodTherapyInfarctionLong delayPresentationOnsetHoursAssociationMinutesRegistry
2006
Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction
Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction. New England Journal Of Medicine 2006, 355: 2308-2320. PMID: 17101617, DOI: 10.1056/nejmsa063117.Peer-Reviewed Original ResearchConceptsST-segment elevationBalloon timeCatheterization laboratoryMyocardial infarctionFaster doorEmergency departmentPrimary percutaneous coronary interventionHospital strategiesIntracoronary balloon inflationPercutaneous coronary interventionAcute myocardial infarctionMinority of hospitalsEmergency medicine physiciansReperfusion treatmentCoronary interventionBalloon inflationMedicine physiciansMultivariate analysisHospitalInfarctionPatientsMedicaid ServicesSignificant reductionReal-time data feedbackData feedback
2005
Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project
Kosiborod M, Curtis JP, Wang Y, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project. JAMA Internal Medicine 2005, 165: 2237-2244. PMID: 16246989, DOI: 10.1001/archinte.165.19.2237.Peer-Reviewed Original ResearchConceptsHeart failureLower hematocrit levelsIndependent predictorsHematocrit levelsComorbid illnessesHigh riskCare ProjectMultivariable logistic regression analysisPatients 65 yearsPrincipal discharge diagnosisAcute care hospitalsLogistic regression analysisLow hematocrit valuesCause mortalityHF patientsMultiple comorbiditiesMultivariable adjustmentOlder patientsCare hospitalClinical factorsHospital readmissionComorbid conditionsDischarge diagnosisSevere anemiaAdverse outcomesThe Obesity Paradox: Body Mass Index and Outcomes in Patients With Heart Failure
Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, Kosiborod M, Portnay EL, Sokol SI, Bader F, Krumholz HM. The Obesity Paradox: Body Mass Index and Outcomes in Patients With Heart Failure. JAMA Internal Medicine 2005, 165: 55-61. PMID: 15642875, DOI: 10.1001/archinte.165.1.55.Peer-Reviewed Original ResearchConceptsBody mass indexHeart failureDigitalis Investigation Group trialBaseline body mass indexStable heart failureStudy of patientsLean patientsObese patientsMass indexHealthy weightAdverse outcomesChronic diseasesGroup trialsGeneral populationStable outpatientsBetter outcomesPatientsOutcomesOverweightObesityOutpatientsDiseaseTrials