Anish Sharda, MD, MPH
Assistant ProfessorCards
About
Research
Publications
2025
Platelet-related biomarkers and catheter-associated thrombosis in critically ill children: An exploratory study
Regmi H, Li I, Prozora S, Sharda A, Shabanova V, Faustino E, Investigators C. Platelet-related biomarkers and catheter-associated thrombosis in critically ill children: An exploratory study. Thrombosis Research 2025, 256: 109534. PMID: 41223722, PMCID: PMC12712714, DOI: 10.1016/j.thromres.2025.109534.Peer-Reviewed Original ResearchConceptsCatheter-associated deep venous thrombosisClinically Relevant BleedingCritically Ill ChildrenCentral venous catheterProphylactic enoxaparinPlatelet factor 4P-selectinIL-6Ill childrenTNF-aPlatelet activationBiomarkers of platelet activationCatheter-associated thrombosisDeep venous thrombosisFactor 4Platelet-poor plasmaSeverity of illnessRelevant bleedingPharmacological prophylaxisPlatelet countVenous cathetersMulticenter studyVenous thrombosisIL-2IL-1BA proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2025, 16: 1676578. PMID: 41181143, PMCID: PMC12571811, DOI: 10.3389/fimmu.2025.1676578.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromeInflammatory signatureClinical trialsAdaptive immune response pathwaysPersistently aPL-positive patientsPathogenesis of antiphospholipid syndromeClinical antiphospholipid syndromePathophysiology of antiphospholipid syndromeAPL-positive patientsCirculating antiphospholipid antibodiesPresence of aPLAntiphospholipid syndrome classificationAdaptive immune activationActivation of coagulationStatistical significanceAntiPhospholipid Syndrome AllianceMultiple pathophysiological mechanismsObstetric morbidityAntiphospholipid antibodiesImmune response pathwaysImmune cellsImmune activationAutoimmune diseasesProteomic screenClinical severityEROdicating arterial thrombosis with a novel endoplasmic reticulum oxidoreductase 1α inhibitor
Yarovinsky T, Sharda A, Hwa J. EROdicating arterial thrombosis with a novel endoplasmic reticulum oxidoreductase 1α inhibitor. Molecular Therapy 2025, 33: 4682-4683. PMID: 40975058, DOI: 10.1016/j.ymthe.2025.09.012.Peer-Reviewed Original ResearchAnalytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome
Butt A, Sharda A, Lee A, Knight J. Analytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome. Transfusion Medicine Reviews 2025, 150909. PMID: 40783311, DOI: 10.1016/j.tmrv.2025.150909.Peer-Reviewed Original ResearchNeutrophil extracellular trapsAntiphospholipid syndromeAdenosine A2A receptorNegative regulatorP-selectin glycoprotein ligand-1Anti-NET antibodiesInduction of NETosisTranscription factor KLF2Regulation of NETosisAutoimmune prothrombotic disorderDecondensed chromatinDevelopment of thrombosisElevated NET levelsNeutrophil-mediated mechanismsGranule proteinsComplement system activationActivated Protein CObstetric complicationsAntiphospholipid antibodiesProthrombotic disordersNeutrophil-derived granule proteinsThrombotic eventsThrombotic riskClinical manifestationsAutoimmune disordersRalB uncoupling from exocyst is required for endothelial Weibel-Palade body exocytosis.
Yang M, Boye-Doe A, Ali M, Abosabie S, Barr A, Mendez L, Sharda A. RalB uncoupling from exocyst is required for endothelial Weibel-Palade body exocytosis. Molecular Biology Of The Cell 2025, 36: ar62. PMID: 40172988, PMCID: PMC12086567, DOI: 10.1091/mbc.e24-11-0493.Peer-Reviewed Original ResearchCongenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans
Allard-Chamard H, Hillier K, Ramseier M, Bertocchi A, Kaneko N, Premo K, Yuen G, Karpel M, Mahajan V, Tsekeri C, Hong J, Vencic J, Crotty R, Sharda A, Barmettler S, Westermann-Clark E, Walter J, Ghebremichael M, Shalek A, Farmer J, Pillai S. Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans. Blood Advances 2025, 9: 520-532. PMID: 39626280, PMCID: PMC11814514, DOI: 10.1182/bloodadvances.2024013267.Peer-Reviewed Original Research
2024
Phenotypic and Transcriptomic Profiling of MPN Endothelium
Abosabie S, Mendez L, Sharda A. Phenotypic and Transcriptomic Profiling of MPN Endothelium. Blood 2024, 144: 1228. DOI: 10.1182/blood-2024-211468.Peer-Reviewed Original ResearchPpara Deletion Promotes Monocytic Leukemia Granulocytic Differentiation
Diolombi M, Sharda A, Chen M, Sejour L, Bester A, Nachmani D, Clohessy J, Pandolfi P, Mendez L. Ppara Deletion Promotes Monocytic Leukemia Granulocytic Differentiation. Blood 2024, 144: 4118. DOI: 10.1182/blood-2024-211508.Peer-Reviewed Original ResearchCRE24-052: Hyperfibrinolysis as the Primary Presenting Sign of Metastatic Prostate Cancer: A Diagnostic Challenge
Lobo A, Zengin Z, Kenworthy C, Sharda A. CRE24-052: Hyperfibrinolysis as the Primary Presenting Sign of Metastatic Prostate Cancer: A Diagnostic Challenge. Journal Of The National Comprehensive Cancer Network 2024, 22 DOI: 10.6004/jnccn.2023.7326.Peer-Reviewed Original Research
2023
Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry
Pine A, Butt A, Garcia-Milian R, Gu S, Restrepo V, Chock Y, Hwa J, Tormey C, Rinder H, Goshua G, Belmont H, Bertolaccini M, Branch D, Erhan D, Kello N, Knight J, Petri M, Willis R, Lee A, Sharda A. Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry. Blood 2023, 142: 2575. DOI: 10.1182/blood-2023-185232.Peer-Reviewed Original ResearchNeutrophil extracellular trapsAntiphospholipid syndromeHumoral immune responseImmune responseClinical phenotypePathophysiology of APSPathogenesis of APSSapporo classification criteriaAPL-positive patientsPathway enrichment analysisEffector cell differentiationAntiPhospholipid Syndrome AllianceDifferent clinical phenotypesProteomic profilingPlasma proteomic profilingPatient plasma samplesAPL antibodiesAPS pathogenesisAntiphospholipid antibodiesObstetric complicationsPositive aPLCytokine stormMedian ageMicrovascular disordersConcurrent diagnosis
Academic Achievements & Community Involvement
Clinical Care
Overview
Anish Sharda, MBBS (a medical degree awarded outside of the U.S.), is a physician-scientist and an assistant professor of medicine at Yale School of Medicine. Dr Sharda is a classical hematologist who specializes in the treatment of bleeding, clotting, and platelet disorders.
Dr. Sharda runs a National Institutes of Health-funded laboratory that conducts research in bleeding and clotting disorders, specifically von Willebrand disease. His research aims to improve understanding of this bleeding disorder as well as discover novel treatments.
Dr. Sharda completed his medical training at B.P. Koirala Institute of Health Sciences in Nepal, followed by a residency in internal medicine at the University of Minnesota Medical Center. He then pursued a clinical and research fellowship in hematology and oncology at Beth Israel Deaconess Medical Center and Harvard Medical School, where he was a faculty member until 2022.
Clinical Specialties
Hematology
Fact Sheets
Bleeding Disorders
Learn More on Yale MedicineBlood Clots in Veins, Heart and Lungs
Learn More on Yale Medicine
Board Certifications
Hematology (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2014
Yale Medicine News
News & Links
Media
Smilow Shares with Primary Care: Benign Hematology and Elevated Blood Counts
January 7, 2025
Presentations by: Frank Ciminiello, MD, Kelsey Martin, MD, and Anish Sharda, MD, MPH
News
- January 08, 2025
Smilow Shares with Primary Care: Benign Hematology and Elevated Blood Counts
- February 15, 2024
Educational Exchange Brings Ugandan Hematologist Dr. Christine Sekaggya-Wiltshire to Yale School of Medicine
- December 08, 2023
New Research Reveals How Modifying a Key Molecular Regulator Could Improve the Treatment of von Willebrand Disease
- November 28, 2023
Yale Cancer Center Experts Present New Research at Hematology Annual Meeting
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Hematology
300 George St
New Haven, Connecticut 06511
United States
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