On May 7, 2024, students and faculty mentors were celebrated at Yale School of Medicine’s (YSM) Student Research Day, an annual tradition at YSM since 1988.
Shelli Farhadian, MD, PhD
Assistant Professor of Medicine (Infectious Diseases)DownloadHi-Res Photo
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MD
Weill Cornell Medical College (2012)
Weill Cornell Medical College (2012)
PhD
The Rockefeller University (2010)
The Rockefeller University (2010)
Clinical Specialties
Infectious Diseases, HIV & AIDs Medicine
Patients Treated
Adult, Older adult
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileEducation
MD
Weill Cornell Medical College (2012)
Weill Cornell Medical College (2012)
PhD
The Rockefeller University (2010)
The Rockefeller University (2010)
Clinical Specialties
Infectious Diseases, HIV & AIDs Medicine
Patients Treated
Adult, Older adult
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileEducation
MD
Weill Cornell Medical College (2012)
Weill Cornell Medical College (2012)
PhD
The Rockefeller University (2010)
The Rockefeller University (2010)
Clinical Specialties
Infectious Diseases, HIV & AIDs Medicine
Patients Treated
Adult, Older adult
About
Titles
Assistant Professor of Medicine (Infectious Diseases)
Assistant Professor, Epidemiology of Microbial Diseases
Appointments
Infectious Diseases
Assistant ProfessorPrimaryEpidemiology of Microbial Diseases
Assistant ProfessorSecondaryNeurology
Assistant ProfessorSecondary
Other Departments & Organizations
- AIDS Care Program
- Brain Infections
- Center for Brain & Mind Health
- Center for Neuroepidemiology and Clinical Neurological Research
- COVID Mind Study at Yale
- Epidemiology of Microbial Diseases
- Infectious Diseases
- Internal Medicine
- Janeway Society
- Neurological Infections and Global Neurology
- Neurology
- Yale Center for Asylum Medicine
- Yale Medicine
- Yale School of Public Health
Education & Training
- T32 Post-doctoral fellow
- Yale School of Medicine (2018)
- Resident
- Yale New Haven Hospital (2015)
- Intern
- Yale New Haven Hospital (2013)
- MD
- Weill Cornell Medical College (2012)
- PhD
- The Rockefeller University (2010)
- BS
- The Massachusetts Institute of Technology, Mathematics (2003)
Research
Overview
My research focuses on the neurological complications of systemic infections, including HIV and COVID-19. After completing my clinical training in Infectious Diseases, I pursued a research fellowship in Neuro-Infectious Diseases at the Yale School of Medicine, focusing my work on neurological complications of HIV in older adults on suppressive antiretroviral therapy. In my clinical role, I care for adults with neurological complications of HIV, Lyme, Syphilis, and other infectious diseases.
Medical Research Interests
Brain; Encephalitis, Arbovirus; HIV; HIV Infections; Infectious Disease Medicine; Internal Medicine; Neurosyphilis
Public Health Interests
HIV/AIDS
Research at a Glance
Yale Co-Authors
Frequent collaborators of Shelli Farhadian's published research.
Publications Timeline
A big-picture view of Shelli Farhadian's research output by year.
Research Interests
Research topics Shelli Farhadian is interested in exploring.
Albert Ko, MD
Akiko Iwasaki, PhD
Serena Susan Spudich, MD, MA
Chantal Vogels, PhD
Nathan Grubaugh, PhD
Benjamin Goldman-Israelow, MD/PhD
39Publications
7,141Citations
Publications
Featured Publications
HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART
Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S. HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART. JCI Insight 2022, 7: e160267. PMID: 35801589, PMCID: PMC9310520, DOI: 10.1172/jci.insight.160267.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebrospinal fluidHIV infectionHIV-1-infected cellsCNS viral persistenceCentral memory CD4T-cell abnormalitiesHIV-1 RNAMicroglia-like cellsT cell activationSystemic viral suppressionAbnormal CD8HIV neuropathogenesisViral suppressionMemory CD4CNS reservoirsImmune perturbationsExperience elevated ratesNeuroimmune effectsPeripheral bloodNeurological impairmentViral persistenceT cellsCell abnormalitiesUninfected controlsCell activationBorrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient
Gandhi S, Narasimhan S, Workineh A, Mamula M, Yoon J, Krause PJ, Farhadian SF. Borrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient. Open Forum Infectious Diseases 2022, 9: ofac295. PMID: 35873293, PMCID: PMC9301576, DOI: 10.1093/ofid/ofac295.Peer-Reviewed Original ResearchCitationsAltmetricEmerging Single-cell Approaches to Understand HIV in the Central Nervous System
Corley MJ, Farhadian SF. Emerging Single-cell Approaches to Understand HIV in the Central Nervous System. Current HIV/AIDS Reports 2021, 19: 113-120. PMID: 34822063, PMCID: PMC8613726, DOI: 10.1007/s11904-021-00586-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCentral nervous systemSingle-cell sequencing methodsSingle-cell approachesStudy of genomesSingle-cell technologiesSingle-cell analysisSingle-cell levelSingle-cell studiesNervous systemMolecular identitySequencing methodsRare infected cellsViral establishmentCentral nervous system tissueInfected cellsNervous system tissueAutopsy brainsCNS reservoirsCSF cellsHIV StudyHIVTranslational studiesCNS perturbationsCNS studiesTissue compartmentsDivergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms
Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Cell Reports Medicine 2021, 2: 100288. PMID: 33969321, PMCID: PMC8091032, DOI: 10.1016/j.xcrm.2021.100288.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNeurological symptomsImmune responseCerebrospinal fluidAnti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesCOVID-19Self-reactive immune responsesSARS-CoV-2 antibodiesCompartmentalized immune responseCSF immunoglobulin GRole of autoimmunityCOVID-19 patientsB cell responsesCoronavirus disease 2019Immune surveyNeurologic sequelaePulmonary infectionBrain infectionSerum antibodiesDisease 2019Monoclonal antibody targetsAnimal modelsTarget epitopesCell activationCell responsesSingle-cell RNA sequencingNeurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC
Locke S, O’Bryan J, Zubair A, Rethana M, Moffarah A, Krause P, Farhadian S. Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1127-1135. PMID: 37209667, PMCID: PMC10202888, DOI: 10.3201/eid2906.221890.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeurologic complicationsNeurologic symptomsRisk factorsYale-New Haven HospitalInfectious Diseases journal - CDCHigh-grade parasitemiaNeurologic risk factorsRange of symptomsAdult patientsRenal failureDiabetes mellitusFrequent symptomsHospital admissionImpaired consciousnessMedical recordsEndemic areasParasitic infectionsPatientsSymptomsIntraerythrocytic protozoaComplicationsBabesiosisNew HavenDeliriumMellitusSingle-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV
Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 2018, 3: e121718. PMID: 30232286, PMCID: PMC6237230, DOI: 10.1172/jci.insight.121718.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebrospinal fluidHIV infectionImmune activationAntiretroviral therapyNeuronal injuryCentral nervous system immune activationLong-term suppressive antiretroviral therapySingle-cell RNA sequencingCNS immune activationDisease-associated microgliaSuppressive antiretroviral therapyImmune cell subsetsMicroglia-like cellsGene expression signaturesNeuronal damageNeuroinflammatory diseasesRNA sequencingCell subsetsCNS cellsNeurological conditionsRare subsetNeurocognitive impairmentMyeloid cellsCellular subsetsInfectionHIV and Age Do Not Synergistically Affect Age-Related T-Cell Markers
Farhadian S, Jalbert E, Deng Y, Goetz MB, Park LS, Justice A, Dubrow R, Emu B. HIV and Age Do Not Synergistically Affect Age-Related T-Cell Markers. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 77: 337-344. PMID: 29140874, PMCID: PMC5807137, DOI: 10.1097/qai.0000000000001595.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCD8 T cellsT-cell markersCD4 T cellsHIV infectionT cellsAntiretroviral therapyEffector memory CD4 T cellsImmune systemVeterans Aging Cohort StudyMemory CD4 T cellsNaive CD4 T cellsAging Cohort StudyT cell subsetsT-cell phenotypeCopies/mLCross-sectional studyRace/ethnicityChronic HIVUninfected subjectsUninfected menCohort studyHIV diseaseHigher proportionHIV serostatusHIV status
2024
Epigenetic Changes in Cerebrospinal Fluid and Blood of People With Neurosyphilis
Mostaghimi D, Mehta S, Yoon J, Kosana P, Marra C, Corley M, Farhadian S. Epigenetic Changes in Cerebrospinal Fluid and Blood of People With Neurosyphilis. The Journal Of Infectious Diseases 2024, jiae476. PMID: 39356164, DOI: 10.1093/infdis/jiae476.Peer-Reviewed Original ResearchAltmetricConceptsPeripheral blood mononuclear cellsCerebrospinal fluidRNA expression changesEpigenetic changesExpression changesBlood mononuclear cellsDifferentially methylated sitesDNA methylation profilesInsulin-responsive pathwaysAntibiotic treatmentImmune cellsB cellsMononuclear cellsMethylation changesDNA methylationMethylation profilesMatched controlsBacterial infectionsNon-NENeurosyphilisBlood of peopleInfectionRNANSRetinal integrity in human babesiosis: a pilot study
Dionne E, Adelman R, Cekic O, Golden M, Moffarah A, Krause P, Farhadian S. Retinal integrity in human babesiosis: a pilot study. BMC Ophthalmology 2024, 24: 310. PMID: 39048971, PMCID: PMC11267664, DOI: 10.1186/s12886-024-03568-6.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsEvidence of retinopathyNo study patientRetina of patientsCohort of patientsAbnormal vessel formationComplication of babesiosisRetinal tearsRetinal inflammationRetinal eye examResultsTen patientsRetinal integrityRetinal examinationRetinal bleedingIndirect ophthalmoscopeRetinal abnormalitiesStudy patientsChart reviewCase reportEye examPilot studyPatientsAnimal studiesSmall studyClinical informationHuman babesiosisA single item screen for clinically significant insomnia symptoms in community‐living older adults
Webster L, Hobbs J, Farhadian S, Gill T, Miner B. A single item screen for clinically significant insomnia symptoms in community‐living older adults. Journal Of The American Geriatrics Society 2024, 72: 3604-3606. PMID: 39007457, PMCID: PMC11560724, DOI: 10.1111/jgs.19086.Peer-Reviewed Original ResearchAltmetric
Academic Achievements & Community Involvement
activity IMPACT: COVID-19 Biorepository at Yale
CommitteesFounding MemberDetails2020 - Presentactivity Yale Center for Asylum Medicine
Public ServiceInvestigatorDetailsMedical forensic evaluator and mentor to medical students2015 - Presenthonor Iva Dostanic Physican-Scientist Award
Yale School of Medicine AwardDetails08/01/2019United Stateshonor Patterson Trust Mentored Research Award
Regional AwardDetails08/01/2018United Stateshonor Young Investigator Award
Regional AwardConnecticut Infectious Disease SocietyDetails08/01/2018United States
Clinical Care
Overview
Clinical Specialties
Infectious Diseases; HIV & AIDs Medicine
Fact Sheets
Human Immunodeficiency Virus (HIV)
Learn More on Yale MedicineSepsis
Learn More on Yale MedicinePediatric Sepsis
Learn More on Yale MedicinePediatric Cancer Immunotherapy
Learn More on Yale Medicine
Board Certifications
Infectious Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
Yale Medicine News
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews & Links
News
- October 10, 2024
Yale Researchers Shed Light on Epigenetic Differences in Patients with Syphilis and Neurosyphilis
- May 14, 2024
Students and Faculty Mentors Celebrated at Student Research Day
- November 10, 2023
Brain Fog: New Study Examines Causes of This Long COVID Symptom
- May 09, 2023
Irene Chernova is the 2023 Dostanic Award Recipient
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.