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Diseases of the Cardiovascular System

DEFIANCE: Randomized Clinical Trial of ClotTriever system versus anticoagulation in Deep Vein Thrombosis

What is the purpose of this trial?

This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.

Currently enrolling patients with:

  • Iliofemoral and unilateral DVT
  • Symptom onset within 12 weeks of enrollment in the study

Follow-up schedule:

  • Patients follow-up tp 6 months

Mechanical thrombectomy with the ClotTriever

Single session procedure

  • No thrombolytics or ICU stay required
  • Trial with
    Inari Medical
  • Ages
    18 years and older
  • Gender
    Both

Contact Information

For more information about this study, including how to volunteer, contact Patricia Fugal

Help Us Discover!

You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.

  • Last Updated
    07/23/2024
  • Study HIC
    #2000034032