Zhengxing Zhang, PhD
Associate Research ScientistCards
About
Research
Publications
2026
Molecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Varli O, Ahmad A, Kukreja G, Zhang Z, Li J, Toczek J, Salarian M, Gona K, Hedayatyanfard K, Zhang J, Alshaeba D, Akar F, Liu C, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Medicine 2026, 67: jnumed.125.271721. PMID: 41887734, PMCID: PMC13224913, DOI: 10.2967/jnumed.125.271721.Peer-Reviewed Original ResearchDevelopment of an Optimized CXCR4-Targeting Theranostic Pair
Kwon D, Bloise I, Zhang Z, Colpo N, Wilson R, Tan R, Merkens H, Zeisler J, Lau J, Lin K, Bénard F. Development of an Optimized CXCR4-Targeting Theranostic Pair. Journal Of Nuclear Medicine 2026, 67: 773-779. PMID: 41611474, PMCID: PMC13138108, DOI: 10.2967/jnumed.125.269933.Peer-Reviewed Original Research
2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original Research
2024
Synthesis and Evaluation of Novel 68Ga-Labeled [D-Phe6,Leu13ψThz14]bombesin(6-14) Analogs for Cancer Imaging with Positron Emission Tomography
Wang L, Chen C, Zhang Z, Kuo H, Zhang C, Colpo N, Merkens H, Bénard F, Lin K. Synthesis and Evaluation of Novel 68Ga-Labeled [D-Phe6,Leu13ψThz14]bombesin(6-14) Analogs for Cancer Imaging with Positron Emission Tomography. Pharmaceuticals 2024, 17: 621. PMID: 38794191, PMCID: PMC11124507, DOI: 10.3390/ph17050621.Peer-Reviewed Original ResearchDevelopment, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy
Bendre S, Merkens H, Kuo H, Ng P, Wong A, Lau W, Zhang Z, Kurkowska S, Chen C, Uribe C, Bénard F, Lin K. Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy. European Journal Of Medicinal Chemistry 2024, 268: 116238. PMID: 38367492, DOI: 10.1016/j.ejmech.2024.116238.Peer-Reviewed Original ResearchUnnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography
Wang L, Kuo H, Zhang Z, Zhang C, Chen C, Chapple D, Wilson R, Colpo N, François Bénard, Lin K. Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography. EJNMMI Radiopharmacy And Chemistry 2024, 9: 8. PMID: 38305955, PMCID: PMC10837402, DOI: 10.1186/s41181-024-00241-7.Peer-Reviewed Original Research
2023
Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
Kuo H, Zhang Z, Zhang C, Merkens H, Tan R, Wong A, Uribe C, Bénard F, Lin K. Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands. Theranostics 2023, 13: 4559-4573. PMID: 37649602, PMCID: PMC10465233, DOI: 10.7150/thno.87663.Peer-Reviewed Original ResearchSynthesis and Evaluation of 99mTc-Labeled PSMA-Targeted Tracers Based on the Lys-Urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography
Lu K, Zhang C, Zhang Z, Kuo H, Colpo N, Bénard F, Lin K. Synthesis and Evaluation of 99mTc-Labeled PSMA-Targeted Tracers Based on the Lys-Urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography. Molecules 2023, 28: 5120. PMID: 37446782, PMCID: PMC10343272, DOI: 10.3390/molecules28135120.Peer-Reviewed Original ResearchMultimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchSynthesis and Preclinical Evaluation of Novel 68Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging
Bendre S, Kuo H, Merkens H, Zhang Z, Wong A, Bénard F, Lin K. Synthesis and Preclinical Evaluation of Novel 68Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging. Pharmaceuticals 2023, 16: 798. PMID: 37375746, PMCID: PMC10303363, DOI: 10.3390/ph16060798.Peer-Reviewed Original Research